Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Anoop Arunagiri"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/810de3a60e3a4ee2af0d2e2b2333bbb4
Autor:
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kina
Externí odkaz:
https://doaj.org/article/07e41593908f4d84a89d335f3da86332
Autor:
Yiping Mao, Jacob Schoenborn, Zhihong Wang, Xinqian Chen, Katy Matson, Ramkumar Mohan, Shungang Zhang, Xiaohu Tang, Anoop Arunagiri, Peter Arvan, Xiaoqing Tang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Abnormal microRNA functions are closely associated with pancreatic β-cell loss and dysfunction in type 2 diabetes. Dysregulation of miR-30d has been reported in the individuals with diabetes. To study how miR-30d affects pancreatic β-cell
Externí odkaz:
https://doaj.org/article/a123c61d7bb345f39e22cb824dcbbaa2
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/8c584d6b7e444a0fb6405c0e280eef9d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Degradation of misfolded proteins from the endoplasmic reticulum (ER) is important for maintaining proper cellular protein homeostasis. Here, the authors discovered that the ER membrane protein PGRMC1 binds to misfolded prohormones for recruitment in
Externí odkaz:
https://doaj.org/article/5cc8072cd71947c2ab1c7a0a4630f5fb
Autor:
Alessandra Galli, Anoop Arunagiri, Nevia Dule, Michela Castagna, Paola Marciani, Carla Perego
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 224 (2023)
Pancreatic β-cells, by secreting insulin, play a key role in the control of glucose homeostasis, and their dysfunction is the basis of diabetes development. The metabolic milieu created by high blood glucose and lipids is known to play a role in thi
Externí odkaz:
https://doaj.org/article/97c7a017fa7247d9984ab25bf9df057e
Autor:
Anoop Arunagiri, Leena Haataja, Anita Pottekat, Fawnnie Pamenan, Soohyun Kim, Lori M Zeltser, Adrienne W Paton, James C Paton, Billy Tsai, Pamela Itkin-Ansari, Randal J Kaufman, Ming Liu, Peter Arvan
Publikováno v:
eLife, Vol 8 (2019)
Biosynthesis of insulin – critical to metabolic homeostasis – begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a su
Externí odkaz:
https://doaj.org/article/e7a8653824104c16932bbe4cb7da543b
Autor:
Xiaoxi Xu, Anoop Arunagiri, Maroof Alam, Leena Haataja, Charles R. Evans, Ivy Zhao, Roberto Castro-Gutierrez, Holger A. Russ, Caroline Demangel, Ling Qi, Billy Tsai, Ming Liu, Peter Arvan
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2023, pp.104836. ⟨10.1016/j.jbc.2023.104836⟩
Journal of Biological Chemistry, 2023, pp.104836. ⟨10.1016/j.jbc.2023.104836⟩
International audience; Insulin is made from proinsulin, but the extent to which fasting/feeding controls the homeostatically-regulated proinsulin pool in pancreatic β-cells remains largely unknown. Here, we first examined β-cell lines (INS1E and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a02a0046fb7b5d4e043e93e2a85b77b
https://hal-pasteur.archives-ouvertes.fr/pasteur-04135046
https://hal-pasteur.archives-ouvertes.fr/pasteur-04135046
Autor:
Sahay, Shruti, Ghosh, Dhiman, Dwivedi, Saumya, Anoop, Arunagiri, Mohite, Ganesh Maruti, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Maji, Samir K.
Publikováno v:
In Journal of Biological Chemistry 20 March 2015 290(12):7804-7822
Pancreatic beta cells maintain glucose homeostasis by secreting pulses of insulin in response to a rise in glucose. Pulsatile secretion occurs due to glucose-induced oscillations in beta-cell cytosolic Ca2+. The endoplasmic reticulum (ER) helps regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b4185dd236682fb70088dd46835b9e1
https://doi.org/10.1101/2022.10.11.511769
https://doi.org/10.1101/2022.10.11.511769