Aptamers as Delivery Agents of siRNA and Chimeric Formulations for the Treatment of Cancer

Autor: Sotiris Missailidis, Dinis Ano Bom Ap, Bonacossa de Almeida Ce, Silva D, da Costa Neves Pc

Publikováno v: Pharmaceutics

Both aptamers and siRNA technologies have now reached maturity, and both have been validated with a product in the market. However, although pegaptanib reached the market some time ago, there has been a slow process for new aptamers to follow. Today,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa28fb52921eb79dbe2fa744ab68fac
https://pubmed.ncbi.nlm.nih.gov/31888119

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine.

Autor: Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Michailidis E; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY., Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY., Chbihi M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Le Voyer T; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Rosain J; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Philippot Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Seeleuthner Y; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France., Gervais A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Materna M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., de Oliveira PMN; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil., Maia MLS; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil., Dinis Ano Bom AP; Laboratory of Immunological Techniques, Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil., Azamor T; Laboratory of Immunological Techniques, Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil., Araújo da Conceição D; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil., Goudouris E; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Homma A; Bio-Manguinhos, Fiocruz, Ministry of Health, Rio de Janeiro, Brazil., Slesak G; Tropical Medicine Department, Tropenklinik Paul-Lechler-Krankenhaus, Tübingen, Germany., Schäfer J; Tropical Medicine Department, Tropenklinik Paul-Lechler-Krankenhaus, Tübingen, Germany., Pulendran B; Emory Vaccine Center and the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.; Institute for Immunity, Transplantation and Infection, Department of Pathology, Department of Microbiology and Immunology, Stanford University, Stanford, CA., Miller JD; Emory Vaccine Center and the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.; Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Scientific Resources, Atlanta, GA., Huits R; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Rosen LB; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Bizien L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Chrabieh M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France., Erazo LV; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France., Rozenberg F; Laboratory of Virology, University of Paris, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Jeljeli MM; Laboratory of Immunology, University of Paris, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Béziat V; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Su HC; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Ahmed R; Emory Vaccine Center and the Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA., Puel A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Abel L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Seligman SJ; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; New York Medical College, Valhalla, NY., Zhang Q; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY., Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY., Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY., Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U1163, Necker Hospital for Sick Children, Paris, France.; University of Paris, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.; Howard Hughes Medical Institute, New York, NY.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4).

Saccharomyces cerevisiae asparaginase II, a potential antileukemic drug: Purification and characterization of the enzyme expressed in Pichia pastoris.

Autor: Facchinetti de Castro Girão L; Federal University of Rio de Janeiro, Institute of Chemistry, Department of Biochemistry, Enzyme Technology Laboratory, 21941-909, Rio de Janeiro, Rio de Janeiro, Brazil; Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Toxinology Laboratory, 21040-900, Rio de Janeiro, Rio de Janeiro, Brazil., Gonçalves da Rocha SL; Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Toxinology Laboratory, 21040-900, Rio de Janeiro, Rio de Janeiro, Brazil., Sobral RS; Federal University of Rio de Janeiro, Institute of Chemistry, Department of Biochemistry, Enzyme Technology Laboratory, 21941-909, Rio de Janeiro, Rio de Janeiro, Brazil., Dinis Ano Bom AP; Oswaldo Cruz Foundation, Biomanguinhos, Laboratory of Macromolecules, 21040-900, Rio de Janeiro, Rio de Janeiro, Brazil., Franco Sampaio AL; Oswaldo Cruz Foundation, Farmanguinhos, Institute of Pharmaceutical Technology, 21041-250, Rio de Janeiro, Rio de Janeiro, Brazil., Godinho da Silva J Jr; Oswaldo Cruz Foundation, Biomanguinhos, Laboratory of Macromolecules, 21040-900, Rio de Janeiro, Rio de Janeiro, Brazil., Ferrara MA; Oswaldo Cruz Foundation, Farmanguinhos, Drugs Technology Laboratory, 21041-250, Rio de Janeiro, Rio de Janeiro, Brazil., Pinto da Silva Bon E; Federal University of Rio de Janeiro, Institute of Chemistry, Department of Biochemistry, Enzyme Technology Laboratory, 21941-909, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: elba1996@iq.ufrj.br., Perales J; Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Toxinology Laboratory, 21040-900, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: jperales@ioc.fiocruz.br.

Publikováno v: Protein expression and purification [Protein Expr Purif] 2016 Apr; Vol. 120, pp. 118-25. Date of Electronic Publication: 2015 Dec 20.

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

Autor: Ano Bom AP; Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil., Rangel LP, Costa DC, de Oliveira GA, Sanches D, Braga CA, Gava LM, Ramos CH, Cepeda AO, Stumbo AC, De Moura Gallo CV, Cordeiro Y, Silva JL

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2012 Aug 10; Vol. 287 (33), pp. 28152-62. Date of Electronic Publication: 2012 Jun 19.

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors.

Autor: Levy CB; Departamento de Genética, Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Rio de Janeiro 20550-013, Brazil., Stumbo AC, Ano Bom AP, Portari EA, Cordeiro Y, Silva JL, De Moura-Gallo CV

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2011 Jan; Vol. 43 (1), pp. 60-4. Date of Electronic Publication: 2010 Nov 05.