Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Anny Usheva"'
Autor:
Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, Krishna G. Bellam, Debolina Banerjee, Anny Usheva, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100052- (2023)
Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic myocardium. The aim of this
Externí odkaz:
https://doaj.org/article/e9557c7c57a44d25bb14e0eb64c8f0f3
Autor:
Mark Broadwin, Dwight D. Harris, Sharif A. Sabe, Elif Sengun, Amber J. Sylvestre, Boian S. Alexandrov, Frank W. Sellke, Anny Usheva
Publikováno v:
Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)
Abstract Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease. Unfortunately, effective prevention and long‐term treatment options remain limited. We d
Externí odkaz:
https://doaj.org/article/1ef5d5352a9a46db982db17c820b2f92
Metabolic Syndrome Induced Metabolomic Alterations in a Porcine Model of Chronic Myocardial Ischemia
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100180- (2023)
Externí odkaz:
https://doaj.org/article/1599c42b79104e629f23f1f1a572cce8
Autor:
Olivia Ziegler, Nivedita Sriram, Vladimir Gelev, Denitsa Radeva, Kostadin Todorov, Jun Feng, Frank W. Selke, Simon C. Robson, Makoto Hiromura, Boian S. Alexandrov, Anny Usheva
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Although metabolic syndrome (MetS) is linked to an elevated risk of cardiovascular disease (CVD), the cardiac-specific risk mechanism is unknown. Obesity, hypertension, and diabetes (all MetS components) are the most common form of CVD and r
Externí odkaz:
https://doaj.org/article/a44ca10268c34958baec7121327a4503
Autor:
Olivia Ziegler, Nivedita Sriram, Vladimir Gelev, Denitsa Radeva, Kostadin Todorov, Jun Feng, Frank W. Sellke, Simon C. Robson, Makoto Hiromura, Boian S. Alexandrov, Anny Usheva
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/3c4c33c8d83e44f096b11e95ee1569a2
Autor:
Maryam Karimi, Vasile I Pavlov, Olivia Ziegler, Nivedita Sriram, Se-Young Yoon, Vahid Agbortoko, Stoiana Alexandrova, John Asara, Frank W Sellke, Michael Sturek, Jun Feng, Boian S Alexandrov, Anny Usheva
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225857 (2019)
Although the high-fat-diet-induced metabolic syndrome (MetS) is a precursor of human cardiac pathology, the myocardial metabolic state in MetS is far from clear. The discrepancies in metabolite handling between human and small animal models and the d
Externí odkaz:
https://doaj.org/article/e5f7dde9dcd94c229245e869d1b0cae9
Autor:
Kristy Nowak-Lovato, Ludmil B Alexandrov, Afsheen Banisadr, Amy L Bauer, Alan R Bishop, Anny Usheva, Fangping Mu, Elizabeth Hong-Geller, Kim Ø Rasmussen, William S Hlavacek, Boian S Alexandrov
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 1, p e1002881 (2013)
Physicochemical properties of DNA, such as shape, affect protein-DNA recognition. However, the properties of DNA that are most relevant for predicting the binding sites of particular transcription factors (TFs) or classes of TFs have yet to be fully
Externí odkaz:
https://doaj.org/article/e7bab5c0269041c2b9824b11423a177d
Autor:
Boian S. Alexandrov, Vlad I. Valtchinov, Ludmil B. Alexandrov, Vladimir Gelev, Yossi Dagon, Jonathan Bock, Isaac S. Kohane, Kim Ø. Rasmussen, Alan R. Bishop, Anny Usheva
Publikováno v:
PLoS ONE, Vol 6, Iss 6 (2011)
Externí odkaz:
https://doaj.org/article/9740bd98f59a4ae780410cdcffb09f8d
Autor:
Boian S Alexandrov, Vlad I Valtchinov, Ludmil B Alexandrov, Vladimir Gelev, Yossi Dagon, Jonathan Bock, Isaac S Kohane, Kim Ø Rasmussen, Alan R Bishop, Anny Usheva
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19800 (2011)
Trinucleotide repeats sequences (TRS) represent a common type of genomic DNA motif whose expansion is associated with a large number of human diseases. The driving molecular mechanisms of the TRS ongoing dynamic expansion across generations and withi
Externí odkaz:
https://doaj.org/article/4fcc499d21a740f198e930fffdda7eb6
Autor:
Gautam V Shrikhande, Salvatore T Scali, Cleide G da Silva, Scott M Damrauer, Eva Csizmadia, Prabhakar Putheti, Michaela Matthey, Roy Arjoon, Rakesh Patel, Jeffrey J Siracuse, Elizabeth R Maccariello, Nicholas D Andersen, Thomas Monahan, Clayton Peterson, Sanah Essayagh, Peter Studer, Renata Padilha Guedes, Olivier Kocher, Anny Usheva, Aristidis Veves, Elzbieta Kaczmarek, Christiane Ferran
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14240 (2010)
Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). However, our understanding of the mechanis
Externí odkaz:
https://doaj.org/article/d3b348f1ed9a45d4aeee6c359a4dcace