Výsledky vyhledávání

MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions

Autor: Pierre Cordelier, Talal Al Saati, Anny Souque, Janick Selves, Jérôme Torrisani, Arief A. Suriawinata, Nicolas Carrere, Mael Chalret du Rieu, Gregory J. Tsongalis, Louis Buscail, Marlène Dufresne

Publikováno v: Clinical Chemistry
Clinical Chemistry, 2010, 56 (4), pp.603-12. ⟨10.1373/clinchem.2009.137364⟩

Background: Pancreatic ductal adenocarcinoma (PDAC) has the poorest overall prognosis among gastrointestinal cancers; however, curative resection in early-stage PDAC greatly improves survival rates, indicating the importance of early detection. Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661fbc5bde454aaaa07eb9c1bae48175
https://doi.org/10.1373/clinchem.2009.137364

Zobrazit plný text záznamu

Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled withKRASmutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis

Autor: Ariane Aubert, Barbara Bournet, Eric Assenat, Pierre Senesse, Jean Escourrou, Pierre Cordelier, Marc Barthet, M. Bouisson, Philippe Lévy, Louis Buscail, Philippe Ruszniewski, Pascal Hammel, Dermot O'Toole, Anny Souque, N. Lesavre

Publikováno v: Endoscopy
Endoscopy, Thieme Publishing, 2009, 41 (6), pp.552-7. ⟨10.1055/s-0029-1214717⟩
Endoscopy, 2009, 41 (6), pp.552-7. ⟨10.1055/s-0029-1214717⟩

International audience; BACKGROUND AND STUDY AIMS: Differential diagnosis between pancreatic adenocarcinoma (PADC) and pseudotumoral forms of chronic pancreatitis remains difficult. Mutation of KRAS oncogene is present in 75% to 95% of PADC. This stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8601c04354fe6dd0a9d05e84006e0df6
https://doi.org/10.1055/s-0029-1214717

Zobrazit plný text záznamu

Identification of an Upstream Promoter of the Human Somatostatin Receptor, hSSTR2, Which Is Controlled by Epigenetic Modifications

Autor: Jean-José Maoret, Naïma Hanoun, Anny Souque, Pierre Cordelier, Frédéric Lopez, Jérôme Torrisani, Louis Buscail, Christiane Susini, Henrik Laurell

Publikováno v: Endocrinology
Endocrinology, 2008, 149 (6), pp.3137-47. ⟨10.1210/en.2007-1525⟩

International audience; Somatostatin is a neuropeptide that inhibits exocrine and endocrine secretions of several hormones and negatively regulates cell proliferation. These events are mediated through somatostatin engagement on one of five G protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a41425cbf8bfccfc321fa5cc03601a
https://doi.org/10.1210/en.2007-1525

Zobrazit plný text záznamu

Treatment of experimental murine pancreatic peritoneal carcinomatosis with fibroblasts genetically modified to express IL12: a role for peritoneal innate immunity

Autor: Janick Selves, Christophe Bureau, Hubert Lulka, Jean-Pierre Vinel, Pierre Gourdy, Jean-Marie Péron, Lucien Pradayrol, Bertrand Calippe, Pierre Cordelier, T Al Saati, Anny Souque, Bernard Pipy, B Couderc, J Bernad, Louis Buscail

Publikováno v: Gut. 56:107-114

Peritoneal carcinomatosis from pancreatic cancer has a poor prognosis with a median survival of 3.1 months. This is mainly due to lack of effective treatment. Interleukin 12 (IL12) is a proinflammatory cytokine that has a potent antitumoral effect by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279c6b3d5d6223b2d75739728e8d269c
https://doi.org/10.1136/gut.2005.083477

Zobrazit plný text záznamu

Characterization of the Bystander Effect of Somatostatin Receptor sst2 AfterIn VivoGene Transfer into Human Pancreatic Cancer Cells

Autor: Nicolas Carrère, Anny Souque, Louis Buscail, Lucien Pradayrol, Amani Asnacios, Nicole Vaysse, Christiane Susini, Fabienne Vernejoul, Pierre Cordelier

Publikováno v: Human Gene Therapy. 16:1175-1193

Pancreatic cancer is one of the most aggressive and devastating human malignancies. The present study was conducted to determine whether in vivo sst2 gene transfer into human pancreatic tumors would impair tumor progression, and to characterize sst2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b38fc256c6277412ba048d29c5dbf6d
https://doi.org/10.1089/hum.2005.16.1175

Zobrazit plný text záznamu

Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12

Autor: Anny Souque, Jean-Pierre Vinel, Gilles Favre, Bettina Couderc, Jean-Marie Péron, Louis Buscail, Philippe Rochaix, Victorine Douin-Echinard, Jean-Jacques Voigt, Amani Asnacios

Publikováno v: Journal of Gastroenterology and Hepatology. 19:388-396

Background and Aim: The majority of patients cannot benefit from the conventional curative treatments that are currently used for hepatocellular carcinoma (HCC), which remains a world health problem. Interleukin (IL)-12 is one of the most potent anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478aac75741779003a129a9921e63a89
https://doi.org/10.1111/j.1440-1746.2003.03295.x

Zobrazit plný text záznamu

The Severe Form of Hypertension Caused by the Activating S810L Mutation in the Mineralocorticoid Receptor Is Cortisone Related

Autor: Marie-Edith Rafestin-Oblin, Brigitte Bocchi, Anny Souque, Alain Vandewalle, Jérôme Fagart, G.M. Pinon

Publikováno v: Endocrinology. 144:528-533

A gain of function mutation resulting in the substitution of leucine for serine at codon 810 (S810L) in the human mineralocorticoid receptor (MR) is responsible for early-onset hypertension that is exacerbated in pregnancy. All steroids, including pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d996fc4b1af8706a580cd131ae366c
https://doi.org/10.1210/en.2002-220708

Zobrazit plný text záznamu

A Single Amino Acid Mutation of Ala-773 in the Mineralocorticoid Receptor Confers Agonist Properties to 11β-Substituted Spirolactones

Autor: Jérôme Fagart, Gilles Auzou, Marie-Edith Rafestin-Oblin, Jean-Marie Wurtz, Chantal Hellal-Levy, Anny Souque, Dino Moras

Publikováno v: Molecular Pharmacology. 58:684-691

Sequence analysis revealed a strong homology between the ligand-binding domain (LBD) of the human mineralocorticoid receptor (hMR) and glucocorticoid receptor (hGR). Nevertheless, steroids with bulky C11-substituents bind to hGR, unlike hMR. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c8f8101b9f8462b98baa7f9fdfc6b4
https://doi.org/10.1124/mol.58.4.684

Zobrazit plný text záznamu

Crucial Role of the H11-H12 Loop in Stabilizing the Active Conformation of the Human Mineralocorticoid Receptor

Autor: Jean-Marie Wurtz, Jérôme Fagart, Chantal Hellal-Levy, Marie-Edith Rafestin-Oblin, Anny Souque, Dino Moras

Publikováno v: Molecular Endocrinology. 14:1210-1221

The crystal structures of ligand-free and agonist-associated ligand-binding domain (LBD) of nuclear receptors (NRs) reveal that the amphipathic helix H12 is folded back toward the LBD core in the agonist-associated conformation, allowing the binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056dfe9ccb93a64875ff3b0dc5fa4506
https://doi.org/10.1210/mend.14.8.0502

Zobrazit plný text záznamu

Les hormones corticostéroïdes : mécanismes impliqués dans la reconnaissance de l’aldostérone par le récepteur aux minéralocorticoïdes

Autor: Chantal Hellal-Levy, Jérôme Fagart, Anny Souque, Marie-Edith Rafestin-Oblin

Publikováno v: Journal de la Société de Biologie. 193:355-360

L’aldosterone et le cortisol, principales hormones mineralocorticoides et glucocorticoides chez l’Homme, ont des structures tres proches. Les deux hormones se lient au recepteur aux mineralocorticoides (RM) avec la meme affinite, neanmoins le RM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::650e89de05f63d167c82e2c618804c3a
https://doi.org/10.1051/jbio/1999193040355

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání