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Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer.

Autor: Ehteshami Bejnordi B; Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Veta M; Medical Image Analysis Group, Eindhoven University of Technology, Eindhoven, the Netherlands., Johannes van Diest P; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., van Ginneken B; Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Karssemeijer N; Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Litjens G; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., van der Laak JAWM; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Hermsen M; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Manson QF; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Balkenhol M; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Geessink O; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.; Laboratorium Pathologie Oost Nederland, Hengelo, the Netherlands., Stathonikos N; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., van Dijk MC; Rijnstate Hospital, Arnhem, the Netherlands., Bult P; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Beca F; BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts., Beck AH; BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.; PathAI, Cambridge, Massachusetts., Wang D; BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.; PathAI, Cambridge, Massachusetts., Khosla A; PathAI, Cambridge, Massachusetts.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts., Gargeya R; Harker School, San Jose, California., Irshad H; BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts., Zhong A; Center for Clinical Data Science, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Dou Q; Center for Clinical Data Science, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Chinese University of Hong Kong, Hong Kong, China., Li Q; Center for Clinical Data Science, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Chen H; Chinese University of Hong Kong, Hong Kong, China., Lin HJ; Chinese University of Hong Kong, Hong Kong, China., Heng PA; Chinese University of Hong Kong, Hong Kong, China., Haß C; ExB Research and Development GmbH, Munich, Germany., Bruni E; ExB Research and Development GmbH, Munich, Germany., Wong Q; Munich Business School, Munich, Germany., Halici U; Department of Electrical and Electronics Engineering, Middle East Technical University, Ankara, Turkey.; Neuroscience and Neurotechnology, Graduate School of Natural and Applied Sciences, Middle East Technical University, Ankara, Turkey., Öner MÜ; Department of Electrical and Electronics Engineering, Middle East Technical University, Ankara, Turkey., Cetin-Atalay R; Cancer System Biology Laboratory, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey., Berseth M; NLP LOGIX, Jacksonville, Florida., Khvatkov V; Smart Imaging Technologies, Houston, Texas., Vylegzhanin A; Smart Imaging Technologies, Houston, Texas., Kraus O; Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada., Shaban M; Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom., Rajpoot N; Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom.; Department of Pathology, University Hospitals Coventry and Warwickshire National Health Service Foundation Trust, Coventry, United Kingdom., Awan R; Department of Computer Science and Engineering, Qatar University, Doha, Qatar., Sirinukunwattana K; Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom., Qaiser T; Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom., Tsang YW; Department of Pathology, University Hospitals Coventry and Warwickshire National Health Service Foundation Trust, Coventry, United Kingdom., Tellez D; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Annuscheit J; Hochschule für Technik und Wirtschaft, Berlin, Germany., Hufnagl P; Hochschule für Technik und Wirtschaft, Berlin, Germany., Valkonen M; BioMediTech Institute and Faculty of Medicine and Life Sciences, Tampere University of Technology, Tampere, Finland., Kartasalo K; Hochschule für Technik und Wirtschaft, Berlin, Germany.; BioMediTech Institute and Faculty of Biomedical Science and Engineering, Tampere University of Technology, Tampere, Finland., Latonen L; Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech, University of Tampere, Tampere, Finland., Ruusuvuori P; Hochschule für Technik und Wirtschaft, Berlin, Germany.; Faculty of Computing and Electrical Engineering, Tampere University of Technology, Pori, Finland., Liimatainen K; Hochschule für Technik und Wirtschaft, Berlin, Germany., Albarqouni S; Technical University of Munich, Munich, Germany., Mungal B; Technical University of Munich, Munich, Germany., George A; Technical University of Munich, Munich, Germany., Demirci S; Technical University of Munich, Munich, Germany., Navab N; Technical University of Munich, Munich, Germany., Watanabe S; Department of Bioinformatic Engineering, Osaka University., Seno S; Department of Bioinformatic Engineering, Osaka University., Takenaka Y; Department of Bioinformatic Engineering, Osaka University., Matsuda H; Department of Bioinformatic Engineering, Osaka University., Ahmady Phoulady H; University of South Florida, Tampa, Florida., Kovalev V; Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus., Kalinovsky A; Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus., Liauchuk V; Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus., Bueno G; Visilab, University of Castilla-La Mancha, Ciudad Real, Spain., Fernandez-Carrobles MM; Visilab, University of Castilla-La Mancha, Ciudad Real, Spain., Serrano I; Visilab, University of Castilla-La Mancha, Ciudad Real, Spain., Deniz O; Visilab, University of Castilla-La Mancha, Ciudad Real, Spain., Racoceanu D; INSERM, Laboratoire d'Imagerie Biomédicale, Sorbonne Universiteś, Pierre and Marie Curie University, Paris, France.; Pontifical Catholic University of Peru, San Miguel, Lima, Peru., Venâncio R; Sorbonne University, Pierre and Marie Curie University, Paris, France.

Publikováno v: JAMA [JAMA] 2017 Dec 12; Vol. 318 (22), pp. 2199-2210.