Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Annukka, Pasanen"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Endometrial carcinoma (EC) is one of the most common gynecological cancers in the world. In this work we apply Cox proportional hazards (CPH) and optimal survival tree (OST) algorithms to the retrospective prognostic modeling of disease-spec
Externí odkaz:
https://doaj.org/article/7ecf101a2e9a4dce81939468cfe4ed85
Autor:
Miika Mehine, Terhi Ahvenainen, Sara Khamaiseh, Jouni Härkönen, Siiri Reinikka, Tuomas Heikkinen, Anna Äyräväinen, Päivi Pakarinen, Päivi Härkki, Annukka Pasanen, Anna-Liisa Levonen, Ralf Bützow, Pia Vahteristo
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-10 (2022)
Abstract Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classified into at least three main molecular subtypes according to mutations affecting MED12, HMGA2, or FH. FH-deficient lei
Externí odkaz:
https://doaj.org/article/199d3f3126b54a4fbad0c263ac974ff4
Autor:
Heli Kuisma, Simona Bramante, Kristiina Rajamäki, Lauri J. Sipilä, Eevi Kaasinen, Jaana Kaukomaa, Kimmo Palin, Netta Mäkinen, Jari Sjöberg, Nanna Sarvilinna, Jussi Taipale, Liisa Kauppi, Manuela Tumiati, Antti Hassinen, Janne Pitkäniemi, Jyrki Jalkanen, Sanna Heikkinen, Annukka Pasanen, Oskari Heikinheimo, Ralf Bützow, Niko Välimäki, Lauri A. Aaltonen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many factors have been associated with chromosomal damage, including mechanical forces in a constrained cellular environment. Here the authors reveal an association between parity and chromosomal damage by analysing karyotypes of 1946 uterine leiomyo
Externí odkaz:
https://doaj.org/article/d2e867958c8a4229a73872634dd5e339
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 1034-1042 (2021)
Abstract Background Mismatch repair (MMR) system has been implicated in the response of mammalian cells to ionizing radiation and DNA damaging agents. We investigated the value of the MMR system in predicting response to adjuvant therapy in endometri
Externí odkaz:
https://doaj.org/article/dbd01a947abd43b590f468a9d2626ffe
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0253472 (2021)
ObjectiveTo assess whether the prognostic impact of conventional risk factors and ancillary biomarkers differs across the 2 largest ProMisE molecular subgroups of endometrial carcinoma (EC).MethodsDirect sequencing of POLE exonuclease domain hot spot
Externí odkaz:
https://doaj.org/article/d71ddb2b73cd4825865a760f909702f2
Autor:
Anne Kolehmainen, Annukka Pasanen, Taru Tuomi, Riitta Koivisto-Korander, Ralf Bützow, Mikko Loukovaara
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242733 (2020)
BackgroundClinical factors may influence endometrial cancer survival outcomes. We examined the prognostic significance of age, body mass index (BMI), and type 2 diabetes among molecular subgroups of endometrial cancer.MethodsThis was a single institu
Externí odkaz:
https://doaj.org/article/0daeac62f9b14433ab15a36be613c748
Autor:
Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A. Aaltonen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior st
Externí odkaz:
https://doaj.org/article/15a7fd008b7b42a49d3e827b391c4772
Autor:
Vilja Jokinen, Miika Mehine, Siiri Reinikka, Sara Khamaiseh, Terhi Ahvenainen, Anna Äyräväinen, Päivi Härkki, Ralf Bützow, Annukka Pasanen, Pia Vahteristo
Publikováno v:
Genes, Chromosomes and Cancer. 62:27-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d596c13d754b496d2f75eb89d34290
https://doi.org/10.1002/gcc.23088
https://doi.org/10.1002/gcc.23088
Autor:
Jonna Similä-Maarala, Piret Soovares, Annukka Pasanen, Terhi Ahvenainen, Pia Vahteristo, Ralf Bützow, Heini Lassus
Publikováno v:
Gynecologic Oncology. 165:577-584
Publisher Copyright: © 2022 The Authors Background: Clear cell and endometrioid ovarian carcinomas (OCC and OEC, respectively) have a presumed origin in endometriosis and share molecular alterations with each other and with their endometrial counter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1245ba46e729c141a1b7bbd5d523f458
https://doi.org/10.1016/j.ygyno.2022.03.016
https://doi.org/10.1016/j.ygyno.2022.03.016
Autor:
Åsa Kolterud, Niko Välimäki, Heli Kuisma, Joonatan Patomo, Sini T Ilves, Netta Mäkinen, Jaana Kaukomaa, Kimmo Palin, Eevi Kaasinen, Auli Karhu, Annukka Pasanen, Ralf Bützow, Oskari Heikinheimo, Helena Kopp Kallner, Lauri A Aaltonen
Precision medicine carries great potential for management of all tumor types. The aim of this retrospective study was to investigate if the two most common genetically distinct uterine fibroid subclasses, driven by aberrations in MED12 and HMGA2 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d12910fc5d0ee57abb7487c407ceffb
http://hdl.handle.net/10138/357414
http://hdl.handle.net/10138/357414
