Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Annmarie Louise Sabb"'
Autor:
Annmarie Louise Sabb, John R. Potoski, Deborah Ann Evrard, Gary Paul Stack, Mairead Young, Robert Lewis Vogel, Melissa Lin, Boyd L. Harrison, Antonia Nikitenko
Publikováno v:
Organic Process Research & Development. 12:76-80
An alternative synthesis of WAY-253752, 1, a novel, dual-acting SSRI/5HT1A antagonist, was developed and used for the first scale-up. Initially, the target compound was synthesized as part of a diasteromeric mixture separated by chiral preparative HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a9164c2fee886f29d0336e777cd8109
https://doi.org/10.1021/op700181n
https://doi.org/10.1021/op700181n
Autor:
Jessica E. Malberg, Gary Paul Stack, James E. Barrett, Sharon Rosenzweig-Lipson, John Dunlop, Annmarie Louise Sabb, Steven M. Grauer, P J Mitchell, Stacey J. Sukoff Rizzo, Julie A. Brennan, John F. Cryan, Karen L. Marquis, Irwin Lucki
Publikováno v:
Psychopharmacology. 192:159-170
Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs. The present studies were conducted to evaluate the effects of the novel 5-HT2C receptor agonist WAY-163909 in animal models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d292cbe54d82e837f9779f2d46b59da
https://doi.org/10.1007/s00213-007-0710-6
https://doi.org/10.1007/s00213-007-0710-6
Autor:
Annmarie Louise Sabb, Karen L. Marquis, James E. Barrett, Boyd L. Harrison, Sharon Rosenzweig-Lipson, Lee A. Dawson, Michael J. Piesla, Gary Paul Stack, Julie A. Brennan, Sheree F. Logue, Herbert Y. Meltzer, Huy Nguyen, Tom A. Comery, Steven M. Grauer, Charles R. Ashby
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:486-496
Serotonin-2C (5-HT 2C ) receptor antagonists and agonists have been shown to affect dopamine (DA) neurotransmission, with agonists selectively decreasing mesolimbic DA. As antipsychotic efficacy is proposed to be associated with decreased mesolimbic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d45c7f2e03a4a7a18992cbf5960ac0
https://doi.org/10.1124/jpet.106.106989
https://doi.org/10.1124/jpet.106.106989
Autor:
Jean Zhang, Boyd L. Harrison, Robert Lewis Vogel, Sharon Rosenzweig-Lipson, John Dunlop, Annmarie Louise Sabb, Stacey J. Sukoff, Eugenia Shukhina, Sachin Kalgaonker, Lee E. Schechter, Hossein Mazandarani, Gary Paul Stack
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:862-869
The pharmacological profile of WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine (HT)(2C) (serotonin) receptor-selective agonist is presented. WAY-163909 displaced [(125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe052f37866103ef8418d6d79de44b3
https://doi.org/10.1124/jpet.104.075382
https://doi.org/10.1124/jpet.104.075382
Autor:
Sharon Rosenzweig-Lipson, Hossein Mazandarani, Denise Graziano, John Dunlop, John R. Potoski, Welmaker Gregory Scott, Yingxin Zhang, Joseph Coupet, Annmarie Louise Sabb, James Albert Nelson, Michael Z. Kagan, Joan E. Sabalski, Stacey J. Sukoff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1991-1994
A series of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines was shown to exhibit 5-HT2C agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7b37b2f16fc2b0b871ffb2bfc1c2da
https://doi.org/10.1016/s0960-894x(00)00400-5
https://doi.org/10.1016/s0960-894x(00)00400-5
Autor:
Rene P. Tasse, Carl A. Boast, Annmarie Louise Sabb, Deepa Malhotra, Herman Morris, Denise Fairman, Reinhardt P. Stein, Magid Abou-Gharbia, Adam C. Bartolomeo, Tracy Sailer, Douglas M. Ho, John A. Moyer, Robert Lewis Vogel, Susan Amburn, Dianne Kowal
Publikováno v:
Drug Development Research. 40:185-192
Computer modeling of carbachol docked in the human m 1 receptor binding pocket has been used to discover a series of carbamate and thiocarbamate chiral, conformationally restricted analogues of carbachol based on azabicyclo[2.2.1]heptan-3-ol. These m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662252d99f4860a887a42895cd92222d
https://doi.org/10.1002/(sici)1098-2299(199702)40:2<185::aid-ddr8>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199702)40:2<185::aid-ddr8>3.0.co
Autor:
Magid Abou-Gharbia, Rene P. Tasse, Carl A. Boast, Reinhardt P. Stein, Joseph Tokolics, John A. Moyer, G. E. Morris Husbands, Annmarie Louise Sabb
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf5fef218b1d2e099f1583b4356b1dc
https://doi.org/10.1002/chin.199943279
https://doi.org/10.1002/chin.199943279
Autor:
Yvette Latko Palmer, Lee E. Schechter, Terrance H. Andree, Michael G. Kelly, Robert Lewis Vogel, Deborah L. Smith, Annmarie Louise Sabb
Publikováno v:
ChemInform. 32
Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT 1A receptor agonists and antagonists, which have selective affinity for 5-HT 1A receptors versus α 1 and dopamine (D 2 , D 3 , and D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d61cf23307c14cb397a8eb23b90dbac4
https://doi.org/10.1002/chin.200133183
https://doi.org/10.1002/chin.200133183
Autor:
Jean Zhang, Gary Paul Stack, Joan E. Sabalski, James E. Barrett, Boyd L. Harrison, Greg Welmaker, John Dunlop, Annmarie Louise Sabb, Sharon Rosenzweig-Lipson, Hossein Mazandarani
Publikováno v:
Brain research.
WAY-161503 ((4a R )-8,9-dichloro-2,3,4,4a-tetrahydro-1 H -pyrazino[1,2-a]quinoxalin-5(6 H )-one), a 5-HT 2B/C receptor agonist, was characterized in vitro using stable Chinese hamster ovary cell lines expressing each of the human 5-HT 2 receptors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd9264c4d1f1b71647d1418a2d918a0
https://pubmed.ncbi.nlm.nih.gov/16430874
https://pubmed.ncbi.nlm.nih.gov/16430874
Autor:
Joan E. Sabalski, Boyd L. Harrison, Annmarie Louise Sabb, Sharon Rosenzweig-Lipson, Welmaker Gregory Scott, Joseph Coupet, Robert Lewis Vogel, B. John Dunlop
Publikováno v:
ChemInform. 35
Evaluation of selected compounds from our Corporate Compound Library in a human 5-HT(2C) receptor binding assay led to the discovery of WAY-629, a cyclohexyl[b][1,4]benzodiazepinoindole (K(i) 56 nM, E(max) 90%), which is selective for the 5-HT(2C) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e51690b509fb9f80ddc8ab0783fea0
https://doi.org/10.1002/chin.200438174
https://doi.org/10.1002/chin.200438174