Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Annissa J Huhn"'
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40030 (2012)
Angiogenesis is tightly regulated through complex crosstalk between pro- and anti-angiogenic signals. High molecular weight kininogen (HK) is an endogenous protein that is proteolytically cleaved in plasma and on endothelial cell surfaces to HKa, an
Externí odkaz:
https://doaj.org/article/f7f2eed4b5154936811cd8b7ecd37cda
Autor:
Anna S. Gardberg, Annissa J. Huhn, Richard Cummings, Archana Bommi-Reddy, Florence Poy, Jeremy Setser, Valerie Vivat, Francois Brucelle, Jonathan Wilson
Publikováno v:
Structural Dynamics, Vol 6, Iss 5, Pp 054702-054702-5 (2019)
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) catalyze the dynamic and reversible acetylation of proteins, an epigenetic regulatory mechanism associated with multiple cancers. Indeed, HDAC inhibitors are already approved in the c
Externí odkaz:
https://doaj.org/article/00d4b497da21451cbeb22fa2b55cf9b5
Autor:
Anna S. Gardberg, Francois Brucelle, Robert J. Sims, Nico Cantone, Richard T. Cummings, Florence Poy, Archana Bommi-Reddy, Julian Levell, Jonathan E. Wilson, Chirag Patel, Annissa J. Huhn, Gaurav Patel
Publikováno v:
ACS Med Chem Lett
[Image: see text] The histone acetyltransferases, CREB binding protein (CBP) and EP300, are master transcriptional co-regulators that have been implicated in numerous diseases, such as cancer, inflammatory disorders, and neurodegeneration. A novel, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2764a1e42c0ba51b33145846879f07
https://doi.org/10.1021/acsmedchemlett.0c00155
https://doi.org/10.1021/acsmedchemlett.0c00155
Autor:
Gregory H. Bird, James Luccarelli, Rachel M. Guerra, Loren D. Walensky, Zachary J. Hauseman, Thomas E. Wales, John R. Engen, James A. Wells, Susan Lee, Hyuk-Soo Seo, T. Justin Rettenmaier, Sirano Dhe-Paganon, Catherine E. Newman, Edward P. Harvey, Danny Cohen, Annissa J. Huhn
Publikováno v:
Cell Chem Biol
Summary The BCL-2 family is composed of anti- and pro-apoptotic members that respectively protect or disrupt mitochondrial integrity. Anti-apoptotic overexpression can promote oncogenesis by trapping the BCL-2 homology 3 (BH3) “killer domains” of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7b1f80414395cfe2149f38f73d4863
https://europepmc.org/articles/PMC7405809/
https://europepmc.org/articles/PMC7405809/
Autor:
Daniel T. Cohen, Silvia Escudero, Catherine G Gallagher, Thomas E. Wales, John R. Engen, Loren D. Walensky, Susan Lee, Annissa J. Huhn, Nicole A. Cohen, James Luccarelli, Gregory H. Bird
Publikováno v:
Nature structural & molecular biology
MCL-1 is an antiapoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer. Like BCL-2, MCL-1 bears a surface groove whose function is to sequester the BH3 killer domains of proapoptotic BCL-2 family members, a mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3006f3ab768370c7209b2d81f4627e
https://doi.org/10.1038/nsmb.3223
https://doi.org/10.1038/nsmb.3223
Autor:
Derek Parsonage, Frank M. Torti, Suzy V. Torti, David A. Horita, Thomas Hollis, Annissa J. Huhn
Publikováno v:
Protein Science. 23:1013-1022
High-molecular-weight kininogen domain 5 (HK5) is an angiogenic modulator that is capable of inhibiting endothelial cell proliferation, migration, adhesion, and tube formation. Ferritin can bind to a histidine–glycine–lysine-rich region within HK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62846691db781d76cbe4be72f2d1d1a8
https://doi.org/10.1002/pro.2486
https://doi.org/10.1002/pro.2486
Autor:
Valerie Vivat, Florence Poy, Annissa J. Huhn, Jeremy W. Setser, Jonathan E. Wilson, Francois Brucelle, Richard D. Cummings, Anna S. Gardberg, Archana Bommi-Reddy
Publikováno v:
Structural Dynamics, Vol 6, Iss 5, Pp 054702-054702-5 (2019)
Structural Dynamics
Structural Dynamics
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) catalyze the dynamic and reversible acetylation of proteins, an epigenetic regulatory mechanism associated with multiple cancers. Indeed, HDAC inhibitors are already approved in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fd56ad3d5299802da5b1abfb7135ca
https://doi.org/10.1063/1.5119336
https://doi.org/10.1063/1.5119336
Autor:
Barbara M. Bryant, Jonathan E. Wilson, Richard D. Cummings, Julian Levell, Andrew R. Conery, Robert J. Sims, Michael J. Steinbaugh, Florence Poy, Sungmi Park, Esteban A. Terzo, Annissa J. Huhn, Archana Bommi-Reddy
Publikováno v:
Cancer Research. 79:4722-4722
Mammalian cell identity or cell fate is governed by transcription factors that recruit co-activators to regulate cell-specific gene expression programs. The histone acetyltransferase (HAT) paralogs EP300 and CREB binding protein (CBP) are master tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::339195f14a90b322f83e7c599519bb59
https://doi.org/10.1158/1538-7445.am2019-4722
https://doi.org/10.1158/1538-7445.am2019-4722
Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors
Publikováno v:
Cell chemical biology. 23(9)
Anti-apoptotic BCL-2 family proteins block cell death by trapping the critical α-helical BH3 domains of pro-apoptotic members in a surface groove. Cancer cells hijack this survival mechanism by overexpressing a spectrum of anti-apoptotic members, mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9031a97f8b68c8f880e71433c1ff37
https://pubmed.ncbi.nlm.nih.gov/27662249
https://pubmed.ncbi.nlm.nih.gov/27662249
Autor:
V. Vivat, Jonathan E. Wilson, J. Setser, Anna Gardberg, F. Poy, F. Brucelle, Annissa J. Huhn, A. Reddy
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:a16-a16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e8c8cb33bcc342779d1f0506ba4166a
https://doi.org/10.1107/s010876731809983x
https://doi.org/10.1107/s010876731809983x