Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Annika de Sousa Linhares"'
Autor:
Rita F. Santos, Annika de Sousa Linhares, Peter Steinberger, Simon. J. Davis, Liliana Oliveira, Alexandre M. Carmo
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background T-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular signalosome, it is distinguished from typical scaffolds like LAT or PAG by possessing a su
Externí odkaz:
https://doaj.org/article/e75938de1adf4148a1f3617d7c5720b5
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109267- (2024)
Summary: Costimulatory signals provided to T cells during antigen encounter have a decisive role in the outcome of immune responses. Here, we used chimeric receptors harboring the extracellular domain of mouse inducible T cell costimulator (mICOS) to
Externí odkaz:
https://doaj.org/article/86c2fadc64284fac8bae57cfa2ae9f0e
Autor:
Joshua Tobias, Claire Battin, Annika De Sousa Linhares, Michael Lebens, Karin Baier, Katharina Ambroz, Mirjana Drinić, Sandra Högler, Aleksandra Inic-Kanada, Erika Garner-Spitzer, Matthias Preusser, Lukas Kenner, Michael Kundi, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies. However, high costs for mono- or combination therapies, associated with adverse
Externí odkaz:
https://doaj.org/article/35ad9cad6fd548f381d461c4dd95deb2
Autor:
Claire Battin, Annika De Sousa Linhares, Wolfgang Paster, David E. Isenman, Markus Wahrmann, Judith Leitner, Gerhard J. Zlabinger, Peter Steinberger, Johannes Hofer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Complement split products (CSPs), such as the fragments C4d and C3d, which are generated as a consequence of complement regulatory processes, are established markers for disease activity in autoimmunity or antibody-mediated graft rejection. Since imm
Externí odkaz:
https://doaj.org/article/89a13f69e21d4155843fc2e1f9758be8
Autor:
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets i
Externí odkaz:
https://doaj.org/article/047865d7fd8148eaa6dae7f74843a9ea
Autor:
Rita F. Santos, Annika De Sousa Linhares, Marcos S. Cardoso, Ana Nóvoa, Hervé Luche, Fátima Gärtner, Bernard Malissen, Peter Steinberger, Simon. J. Davis, Moisés Mallo, Liliana Oliveira, Alexandre M. Carmo
T-cell membrane scaffold proteins play important roles in T cell biology, functioning as multi-functional signaling hubs. CD6 assembles a large intracellular signalosome but, unlike typical membrane-attached scaffolds like LAT or PAG, it has a sizeab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8e52444fee8c6e0d85943771c8163b
https://doi.org/10.1101/2022.04.29.490054
https://doi.org/10.1101/2022.04.29.490054
Autor:
Benjamin Salzer, Irene Schaffner, Kristina Djinović-Carugo, Michael W. Traxlmayr, Annika De Sousa Linhares, Wolfgang Holter, Manfred Lehner, Peter Steinberger, Nicole J. Yang, Christian Obinger, Charlotte U. Zajc, Markus Dobersberger, G. Mlynek, Dominic Pühringer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Molecular ON-switches are important tools in chemical biology, enabling protein–protein interactions to be regulated by small molecules. However, currently available ON-switches that induce conditional heterodimerization are suboptimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7f8213a9d6b594eef65dc5a3b709dc
http://europepmc.org/articles/PMC7334647
http://europepmc.org/articles/PMC7334647
Autor:
Peter Steinberger, Judith Leitner, Johannes B. Huppa, Hans-Joachim Gabius, Gerhard J. Zlabinger, Annika De Sousa Linhares, Florian Kellner, Sabrina Jutz
Publikováno v:
European Journal of Immunology
TIM‐3 has been considered as a target in cancer immunotherapy. In T cells, inhibitory as well as activating functions have been ascribed to this molecule. Its role may therefore depend on the state of T cells and on the presence of interaction part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031998fe7cc5c89b53a858f830434a7f
https://doi.org/10.1002/eji.201948400
https://doi.org/10.1002/eji.201948400
Autor:
Hans-Joachim Gabius, Johannes B. Huppa, Judith Leitner, Florian Kellner, Sabrina Jutz, Peter Steinberger, Annika De Sousa Linhares, Gerhard J. Zlabinger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da1c6a52123f63b65b31effe43bb815
https://doi.org/10.1002/eji.201948400/v2/response1
https://doi.org/10.1002/eji.201948400/v2/response1
Autor:
Michael Lebens, Claire Battin, Matthias Preusser, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann, Aleksandra Inic-Kanada, Katharina Ambroz, Joshua Tobias, Erika Garner-Spitzer, Michael Kundi, Karin Baier, Sandra Högler, Annika De Sousa Linhares, Mirjana Drinić, Lukas Kenner
Publikováno v:
Cancer Research. 80:3151-3151
Application of monoclonal antibodies (mAbs) as immune checkpoint inhibitors (ICIs) has demonstrated a tremendous effect in cancer immunotherapy. However, high costs for and frequent applications of mono- or combination-therapies or possible developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb19083a1aebd2967b0adacadc0ee3b4
https://doi.org/10.1158/1538-7445.am2020-3151
https://doi.org/10.1158/1538-7445.am2020-3151