Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Annika Westin"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Lack of complement factor C1q of the classical pathway results in severely impaired primary antibody responses. This is a paradox because antibodies, especially IgM, are the most efficient activators of the classical pathway and very little specific
Externí odkaz:
https://doaj.org/article/f78a973f2930453f98018ce625f27344
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Follicular dendritic cells (FDCs) are rare and enigmatic cells that mainly reside in germinal centers (GCs). They are capable of capturing immune complexes, via their Fc (FcRs) and complement receptors (CRs) and storing them for long periods in non-d
Externí odkaz:
https://doaj.org/article/0c36e8e0f7404e7fa30a35e5166c7357
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Antigen-specific IgG antibodies, passively administered together with erythrocytes, prevent antibody responses against the erythrocytes. The mechanism behind the suppressive ability of IgG has been the subject of intensive studies, yet there is no co
Externí odkaz:
https://doaj.org/article/639f30cf5784464eb435a38f88ff1964
Autor:
Hanna Pettersson, Behdad Zarnegar, Annika Westin, Viktor Persson, Christiane Peuckert, Jörgen Jonsson, Jenny Hallgren, Klas Kullander
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. St
Externí odkaz:
https://doaj.org/article/741c7a5b20964df38f985281738b71f6
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice trig
Externí odkaz:
https://doaj.org/article/5e3a620bab5744d9a5bebad7b5741802
Autor:
Hans Ericsson, Igor L. Shamovsky, Carl Whatling, Malin Lemurell, Marianne Swanson, Eva-Lotte Lindstedt, Johan Broddefalk, Mats Någård, Anita Dellsén, Johan Ulander, Carl Amilon, Kenneth Granberg, Annika Westin Eriksson, Daniel Pettersen, Alleyn T. Plowright, Monica Sundqvist, Hans Emtenäs, Martin A. Hayes
Publikováno v:
Journal of Medicinal Chemistry. 62:4312-4324
5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such, they are hypothesized to have therapeutic benefit for the treatment of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f5cbb07e77468dbbb61f1fcb001052
https://doi.org/10.1021/acs.jmedchem.8b02004
https://doi.org/10.1021/acs.jmedchem.8b02004
Autor:
Christian Tyrchan, Anna-Pia Palmgren, Hui-Fang Amy Chang, Yunhua Chen, Victoria Ullah, Karin Björhall, Annika Westin Eriksson, Rebecca Fransson, Mickael Mogemark, Tiiu Wennberg, Shuchun Zhao, Bold Peter, Linda Fredlund, Matthew Thomas, Eva Lamm Bergström, Nils Pemberton, Ulf Börjesson, Reed W. Smith, Mikael Brűlls, Johan Carlsson, Britt-Marie Fihn, Linda Öster, Mio Rodrigo Blomqvist, Hongbin Ge, Antonios Nikitidis, Wenzhen Yang, Anders Eriksson, Haijuan Huang, Sarah Lever, Perry Matthew, Kostas Karabelas, Helena Lindmark, Jens Petersen
Publikováno v:
Journal of medicinal chemistry. 64(12)
Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the molecules, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1afe7cc480e1edf37ab207774eb9ff
https://pubmed.ncbi.nlm.nih.gov/34080862
https://pubmed.ncbi.nlm.nih.gov/34080862
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Follicular dendritic cells (FDCs) are rare and enigmatic cells that mainly reside in germinal centers (GCs). They are capable of capturing immune complexes, via their Fc (FcRs) and complement receptors (CRs) and storing them for long periods in non-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2c7c316fc5a3976e6a9e5c0b90acf0
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443202
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443202
Akademický článek
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Autor:
Annika Westin Eriksson, Matthew Thomas, Mickael Mogemark, Perry Matthew, Raolat M Abdulai, Barbara Valastro, Jens Petersen
Publikováno v:
Journal of Medicinal Chemistry. 62:4783-4814
Phosphoinositol 3-kinases (PI3Ks) γ and δ are key enzymes in hematopoietic cells and have been seen as high-value targets for the treatment of diseases with inflammatory and immunomodulatory components since their discovery and the identification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd2f7166f27f0b1f2779441002da1f7
https://doi.org/10.1021/acs.jmedchem.8b01298
https://doi.org/10.1021/acs.jmedchem.8b01298