Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Annika V. Dalheim"'
1
Akademický článek
Melanoma reactive TCR-modified T cells generated without activation retain a less differentiated phenotype and mediate a superior in vivo response
Autor: Siao-Yi Wang, Tamson V. Moore, Annika V. Dalheim, Gina M. Scurti, Michael I. Nishimura
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Adoptive T cell therapy with T cell receptor (TCR)-modified T cells has shown promise in treating metastatic melanoma and other malignancies. However, studies are needed to improve the efficacy and durability of responses of TCR-modified T c
Externí odkaz: https://doaj.org/article/0d6455e91542435a9f8f3cd3c71292a6
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2
Akademický článek
HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells
Autor: Tamson V. Moore, Gina M. Scurti, Matthew DeJong, Siao-Yi Wang, Annika V. Dalheim, Courtney R. Wagner, Kelli A. Hutchens, Jodi J. Speiser, Constantine V. Godellas, Chris Fountain, Jessica Fleser, Tarsem Moudgil, Mallory Thomas, David Murray, Brendan D. Curti, Joseph I. Clark, Bernard A. Fox, Michael I. Nishimura
Publikováno v: Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 352-363 (2021)
T cells that are gene-modified with tumor-specific T cell receptors are a promising treatment for metastatic melanoma patients. In a clinical trial, we treated seven metastatic melanoma patients with autologous T cells transduced to express a tyrosin
Externí odkaz: https://doaj.org/article/89a5e7e4a04a46e287fbf116f56ea560
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3
Akademický článek
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus
Autor: Long Chen, David F Stroncek, Gang Zeng, Steven Highfill, Robert Reger, Stefan Barisic, Elena Cherkasova, Elizabeth M Brahmbhatt, Timothy T Spear, Ujjawal Savani, Stephanie Pierre, Gina M Scurti, Muna Igboko, Rosa Nadal, Gordon Parry, Annika V Dalheim, Michael I Nishimura, Richard W Childs
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background We discovered a novel human endogenous retrovirus (CT-RCC HERV-E) that was selectively expressed in most clear cell renal cell carcinomas (ccRCC) and served as a source of antigens for T cell-mediated killing. Here, we described the clonin
Externí odkaz: https://doaj.org/article/bdd7b926eb5a41dab026790fbcaa4b31
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8
Melanoma-reactive TCR-modified T Cells Generated in the Absence of Activation Retain a Less-differentiated Phenotype and Have Increased Therapeutic Potential
Autor: Siao-Yi Wang, Tamson V. Moore, Annika V. Dalheim, Gina M. Scurti, Michael I. Nishimura
Adoptive T cell therapy with T cell receptor (TCR)-modified T cells has shown promise in treating metastatic melanoma and other malignancies. However, studies are needed to improve the efficacy and durability of responses of TCR-modified T cells. Sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efde6a44e09348f535ef99bdddd07b8e
https://doi.org/10.21203/rs.3.rs-238261/v1
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