Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Annika Sommerfeld"'
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 6, Pp 1427-1445 (2019)
Externí odkaz:
https://doaj.org/article/b2df231c5db7440cb7b83b260ac40900
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 3, Pp 866-883 (2015)
Background/Aims: Ursodeoxycholic acid, which in vivo is rapidly converted into its taurine conjugate, is frequently used for the treatment of cholestatic liver disease. Apart from its choleretic effects, tauroursodeoxycholate (TUDC) can protect hepat
Externí odkaz:
https://doaj.org/article/13cb487776b147049f76050d7478b78b
Autor:
Tabea A Mundinger, Annika Sommerfeld, Roland Reinehr, Joachim P Spatz, Dieter Häussinger, Heike Boehm
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48100 (2012)
Hepatocyte volume regulation has been shown to play an important role in cellular metabolism, proliferation, viability and especially in hepatic functions such as bile formation and proteolysis. Recent studies on liver explants led to the assumption
Externí odkaz:
https://doaj.org/article/1fbc59316af744c7b433d0b65656fce0
Autor:
Dieter Häussinger, Natalia Qvartskhava, Michele Bonus, Horst Kessler, Beatrice Stefanie Ludwig, Boris Görg, Annika Sommerfeld, Holger Gohlke
Publikováno v:
Scientific reports 10(1), 5795 (2020). doi:10.1038/s41598-020-62326-y
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Functional selectivity is the ligand-specific activation of certain signal transduction pathways at a receptor and has been described for G protein-coupled receptors. However, it has not yet been described for ligands interacting with integrins witho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca2f44e0117078988fe57ee833eadc2
https://hdl.handle.net/2128/24652
https://hdl.handle.net/2128/24652
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 6, Pp 1427-1445 (2019)
Background/aims Hydrophobic bile salts, such as glycochenodeoxycholate (GCDC) can trigger hepatocyte apoptosis, which is prevented by tauroursodesoxycholate (TUDC), but the effects of GCDC and TUDC on sinusoidal bile salt uptake via the Na⁺-tauroch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e1de0af096b542744283e1f9da5375
https://pubmed.ncbi.nlm.nih.gov/31088037
https://pubmed.ncbi.nlm.nih.gov/31088037
Publikováno v:
Journal of Biological Chemistry. 295:2885
Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth factor receptor (EGFR) and subsequent cell proliferation (1). Free fatty acids (FFAs) are known to induce lipoapoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c14f2a81106e342f4e071de396e86ce
https://doi.org/10.1074/jbc.aac120.012827
https://doi.org/10.1074/jbc.aac120.012827
Autor:
Michele, Bonus, Annika, Sommerfeld, Natalia, Qvartskhava, Boris, Görg, Beatrice Stefanie, Ludwig, Horst, Kessler, Holger, Gohlke, Dieter, Häussinger
Publikováno v:
Scientific Reports
Functional selectivity is the ligand-specific activation of certain signal transduction pathways at a receptor and has been described for G protein-coupled receptors. However, it has not yet been described for ligands interacting with integrins witho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f8725aba1a41492dc75e6f54a39204c
https://pubmed.ncbi.nlm.nih.gov/32242141
https://pubmed.ncbi.nlm.nih.gov/32242141
Autor:
Annika Sommerfeld, Ertan Mayatepek, Caroline Klindt, K Deutschmann, Diran Herebian, Verena Keitel, Stefanie Kluge, M Reich, Wolfram T. Knoefel, Ralf Kubitz, Dieter Häussinger, Christoph Ullmer
Publikováno v:
Gut. 65:487-501
Objective Cholestatic liver diseases in humans as well as bile acid (BA)-feeding and common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the portal fields. Furthermore, elevation of BA levels enhances proliferatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6182f78d98581564889d2ac1a0946776
https://doi.org/10.1136/gutjnl-2015-309458
https://doi.org/10.1136/gutjnl-2015-309458
Publikováno v:
Journal of Biological Chemistry. 290:4398-4409
Insulin is known to induce hepatocyte swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth factor receptor (EGFR) and subsequent cell proliferation (1). Free fatty acids (FFAs) are known to induce lipoapoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bde427c51621828d62309b68be15ed8c
https://doi.org/10.1074/jbc.m114.617035
https://doi.org/10.1074/jbc.m114.617035
Autor:
Jürgen Scheller, Annika Sommerfeld, Fabian Kuck, Roland P. Piekorz, Klaus Schulze-Osthoff, Stefan Rose-John, Philipp A. Lang, Mareike Kessenbrock, Christoph Garbers, Kirstin Konzak, Tak W. Mak, Frank Essmann, Dirk Brenner, Dieter Häussinger, Samadhi Aparicio-Siegmund
Publikováno v:
Cell Cycle. 12:3421-3432
Interleukin 6 (IL-6) signaling plays a role in inflammation, cancer, and senescence. Here, we identified soluble IL-6 receptor (sIL-6R) as a member of the senescence-associated secretory phenotype (SASP). Senescence-associated sIL-6R upregulation was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ffa1fad77f712cde7269e78e4dd475
https://doi.org/10.4161/cc.26431
https://doi.org/10.4161/cc.26431