Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.

Autor: Annika Rennenberg, Christine Lehmann, Anna Heitmann, Tina Witt, Guido Hansen, Krishna Nagarajan, Christina Deschermeier, Vito Turk, Rolf Hilgenfeld, Volker T Heussler

Publikováno v: PLoS Pathogens, Vol 6, Iss 3, p e1000825 (2010)

Plasmodium parasites must control cysteine protease activity that is critical for hepatocyte invasion by sporozoites, liver stage development, host cell survival and merozoite liberation. Here we show that exoerythrocytic P. berghei parasites express

Externí odkaz: https://doaj.org/article/4ea5549befea425aa2e2348298b2e841

The macromolecular complex of ICP and falcipain-2 fromPlasmodium: preparation, crystallization and preliminary X-ray diffraction analysis

Autor: Britta Schwarzloh, Annika Rennenberg, Guido Hansen, Rolf Hilgenfeld, Volker Heussler

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 67:1406-1410

The malaria parasite Plasmodium depends on the tight control of cysteine-protease activity throughout its life cycle. Recently, the characterization of a new class of potent inhibitors of cysteine proteases (ICPs) secreted by Plasmodium has been repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ddffa8e4c9a6750f06e5758355ff3e
https://doi.org/10.1107/s1744309111034592

Protozoan parasites: programmed cell death as a mechanism of parasitism

Autor: Thomas Roeder, Iris Bruchhaus, Volker Heussler, Annika Rennenberg

Publikováno v: Trends in Parasitology. 23:376-383

Programmed cell death (PCD) is a potent mechanism to remove parasitized cells, but it has also been shown that protozoan parasites can induce or inhibit apoptosis in host cells. In recent years, it has become clear that unicellular parasites can also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adabe2167f92ee31f0d81fb72fcb89e
https://doi.org/10.1016/j.pt.2007.06.004

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium

Autor: Rolf Hilgenfeld, Tina Witt, Guido Hansen, Volker Heussler, Hualiang Jiang, Honglin Li, Anna Heitmann, Xu Shen, Annika Rennenberg

Publikováno v: Structure (London, England : 1993). 19(7)

SummaryPlasmodium cysteine proteases are essential for host-cell invasion and egress, hemoglobin degradation, and intracellular development of the parasite. The temporal, site-specific regulation of cysteine-protease activity is a prerequisite for su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4013fef5b0eeae1b63e5ccb4852ba8c1
https://pubmed.ncbi.nlm.nih.gov/21742255

Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes

Autor: Tina Witt, Vito Turk, Krishna Nagarajan, Volker Heussler, Guido Hansen, Christina Deschermeier, Christine Lehmann, Annika Rennenberg, Anna Heitmann, Rolf Hilgenfeld

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 3, p e1000825 (2010)
Rennenberg, Annika; Lehmann, Christine; Heitmann, Anna; Witt, Tina; Hansen, Guido; Nagarajan, Krishna; Deschermeier, Christina; Turk, Vito; Hilgenfeld, Rolf; Heussler, Volker (2010). Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes. PLoS pathogens, 6(3), e1000825. Public Library of Science 10.1371/journal.ppat.1000825

Plasmodium parasites must control cysteine protease activity that is critical for hepatocyte invasion by sporozoites, liver stage development, host cell survival and merozoite liberation. Here we show that exoerythrocytic P. berghei parasites express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cb1cb0031fbe6217772d446ea880f0
https://pubmed.ncbi.nlm.nih.gov/20361051