Výsledky vyhledávání - "Annika R. Weiz"

Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines

Autor: Christian Hertweck, Claire Pancrace, Muriel Gugger, Enora Briand, Arthur Guljamow, Keishi Ishida, Nathalie Sassoon, Annika R. Weiz, Thibault Scalvenzi, Douglas Gatte Pichi, Elke Dittmann

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2019, 14 (1), pp.67-75. ⟨10.1021/acschembio.8b00918⟩
ACS Chemical Biology, 2019, 14 (1), pp.67-75. ⟨10.1021/acschembio.8b00918⟩
Acs Chemical Biology (1554-8929) (Amer Chemical Soc), 2019-01, Vol. 14, N. 1, P. 67-75
ACS Chemical Biology, American Chemical Society, 2018, 14 (1), pp.67-75. ⟨10.1021/acschembio.8b00918⟩

International audience; The cyanobacterial genus Microcystis is known to produce an elaborate array of structurally unique and biologically active natural products, including hazardous cyanotoxins. Cytotoxic aeruginoguanidines represent a yet unexplo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31330fbdfa212cf787bb85afbc2bbe92
https://hal-pasteur.archives-ouvertes.fr/pasteur-02044790/document

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Analyse von Protease-Inhibitor-Interaktionen unter Nutzung evolvierbarer tricyclischer Microviridine

Autor: Kristian M. Müller, Christian Hertweck, Keishi Ishida, Sabine Meyer, Felix Quitterer, Annika R. Weiz, Jan-Christoph Kehr, Elke Dittmann, Michael Groll

Publikováno v: Angewandte Chemie. 126:3810-3813

Ein wichtiges Ziel in der therapeutischen Chemie ist das Verstandnis und die Kontrolle von proteolytischen Prozessen. Unter den proteaseinhibierenden Naturstoffen nehmen Microviridine eine Sonderstellung ein. Microviridine sind ribosomal erzeugte und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbec2b9b062bc696dbce79c71df43973
https://doi.org/10.1002/ange.201309721

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Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family

Autor: Keishi Ishida, Douglas Gatte-Picchi, Elke Dittmann, Christian Hertweck, Annika R. Weiz

Microviridins represent a unique family of ribosomally synthesized cage-like depsipeptides from cyanobacteria with potent protease-inhibitory activities. The natural diversity of these peptides is largely unexplored. Here, we describe two methodologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b78614295ab84f334246cb8e6b608
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/38075

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Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions

Autor: Jan-Christoph Kehr, Keishi Ishida, Michael Groll, Kristian M. Müller, Elke Dittmann, Felix Quitterer, Christian Hertweck, Annika R. Weiz, Sabine Meyer

Understanding and controlling proteolysis is an important goal in therapeutic chemistry. Among the natural products specifically inhibiting proteases microviridins are particularly noteworthy. Microviridins are ribosomally produced and posttranslatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9371c1797c506286fb470e1d9ca03c
https://pub.uni-bielefeld.de/record/2684340

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Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin

Autor: Christian Hertweck, Keishi Ishida, Katharina Makower, Nadine Ziemert, Elke Dittmann, Annika R. Weiz

Publikováno v: Chemistrybiology. 18(11)

Microviridins are unique protease inhibitors from bloom-forming cyanobacteria that have both ecological and pharmacological relevance. Their peptide backbones are produced ribosomally, and ATP grasp ligases introduce omega-ester and omega-amide bonds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b01f4f22d700a7177cf02df88d83b75
https://pubmed.ncbi.nlm.nih.gov/22118675

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Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides

Autor: Elke Dittmann, Keishi Ishida, Nadine Ziemert, Annika R. Weiz, Christian Hertweck

Publikováno v: Applied and environmental microbiology. 76(11)

Microviridins are ribosomally synthesized tricyclic depsipeptides produced by different genera of cyanobacteria. The prevalence of the microviridin gene clusters and the natural diversity of microviridin precursor sequences are currently unknown. Scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b20aacacee50719377d80383f08a44f
https://pubmed.ncbi.nlm.nih.gov/20363789

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