Combined Genome-Wide Scan for Prostate Cancer Susceptibility Genes

Autor: Caroline E. Mohai, Ethan M. Lange, Derek Gildea, Erica Riedesel, Bao Li Chang, William B. Isaacs, Kathleen E. Wiley, S. Lilly Zheng, Mary Pat Jones, Johanna Schleutker, John D. Carpten, Jeffrey M. Trent, Kathleen A. Cooney, Teuvo L.J. Tammela, Joan E. Bailey-Wilson, Fredrik Wiklund, Deborah A. Meyers, Agnes Baffoe-Bonnie, Julie Albertus, W. Mark Brown, Annika Rökman, Henrik Grönberg, Sarah D. Isaacs, Mika P. Matikainen, Jianfeng Xu, Patrick C. Walsh, Elizabeth M. Gillanders

Publikováno v: JNCI Journal of the National Cancer Institute. 96:1240-1247

Background: Prostate cancer represents a substantial public health burden worldwide. It is the second leading cause of cancer death among men in the United States. A family history of the disease is among the most well-established risk factors for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9eac58801cfd7166ab4bc1af3fadebc
https://doi.org/10.1093/jnci/djh228

Genetic changes in familial prostate cancer by comparative genomic hybridization

Autor: Johanna Schleutker, Mika P. Matikainen, Tuula Kuukasjärvi, Annika Rökman, Heikki Helin, Marita Poutiainen, Ritva Karhu, Pasi A. Koivisto, Olli-P. Kallioniemi

Publikováno v: The Prostate. 46:233-239

Background Germline mutations in recessive cancer predisposition genes are uncovered by somatic genetic deletions during tumor development. Analysis of genetic changes in tumor tissues from patients with an inherited predisposition may therefore high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00aafa329885124c5a400dea6273f482
https://doi.org/10.1002/1097-0045(20010215)46:3<233::aid-pros1028>3.0.co

Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus

Autor: Henna Fredriksson, Johanna Schleutker, Kenneth D. Gibbs, Elizabeth M. Gillanders, Diane Freas-Lutz, Carol Markey, Mary Pat Jones, Agnes Baffoe-Bonnie, Tarja Ikonen, Jeffrey M. Trent, Teuvo L.J. Tammela, Olli Kallioniemi, Annika Rökman, Joan E. Bailey-Wilson, Mika P. Matikainen, Ville Autio, Pasi A. Koivisto, Derek Gildea

Publikováno v: Rökman, A, Baffoe-Bonnie, A B, Gillanders, E, Fredriksson, H, Autio, V, Ikonen, T, Gibbs Jr, K D, Jones, M, Gildea, D, Freas-Lutz, D, Markey, C, Matikainen, M P, Koivisto, P A, Tammela, T L J, Kallioniemi, O, Trent, J, Bailey-Wilson, J E & Schleutker, J 2005, ' Hereditary prostate cancer in Finland : Fine-mapping validates 3p26 as a major predisposition locus ', Human Genetics, vol. 116, no. 1-2, pp. 43-50 . https://doi.org/10.1007/s00439-004-1214-7

In a recent genome-wide linkage (GWL) analysis of Finnish families at high risk for prostate cancer, we found two novel putative susceptibility loci at 3p25-p26 and 11q14. Here, we report the fine-mapping of these two critical regions at high resolut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c753fa97d3d275ecc32c807341f1a7
https://pubmed.ncbi.nlm.nih.gov/15549392

No fumarate hydratase (FH) mutations in hereditary prostate cancer

Autor: Johanna Schleutker, Julie M. Cunningham, Annika Rökman, Tarja Ikonen, D J Schaid, Mika P. Matikainen, Rainer Lehtonen, S. N. Thibodeau, Nina N. Nupponen, Auli Karhu, Lauri A. Aaltonen, O. P. Kallioniemi, Maija Ht Kiuru

Mutations in fumarate hydratase (fumarase, FH ), a nuclear gene encoding a mitochondrial tricarboxylic acid cycle or Krebs cycle protein also present in the cytosol, have recently been shown to predispose to hereditary leiomyomatosis and renal cell c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b507640998fc8b77c178fa7e39a577a1
https://europepmc.org/articles/PMC1735396/

Chromosomal changes in locally recurrent, hormone-refractory prostate carcinomas by karyotyping and comparative genomic hybridization

Autor: Pasi A. Koivisto, Teuvo L.J. Tammela, C. Palmberg, Marita Laurila, Kyllikki Haapala, E. Hyytinen, Annika Rökman

Publikováno v: Cancer genetics and cytogenetics. 131(1)

The genetic mechanisms of prostate cancer recurrence during hormonal therapy are largely unknown. So far, data from conventional karyotype analysis on hormone-refractory prostate carcinomas have not been published, mainly because of the difficulties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab4c3db85cf759bb1210be1f0e0c0f
https://pubmed.ncbi.nlm.nih.gov/11734323