Výsledky vyhledávání - "Annika Järviluoma"

Akademický článek

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

Autor: Sonja Koopal, Johanna H Furuhjelm, Annika Järviluoma, Sari Jäämaa, Pawan Pyakurel, Christel Pussinen, Maria Wirzenius, Peter Biberfeld, Kari Alitalo, Marikki Laiho, Päivi M Ojala

Publikováno v: PLoS Pathogens, Vol 3, Iss 9, Pp 1348-1360 (2007)

Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)-infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA. Despite a strong link between KSHV infection and certain neoplas

Externí odkaz: https://doaj.org/article/2f23eda7c9764a07baabb81a431641b6

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Akademický článek

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

Autor: Iivari Kleino, Annika Järviluoma, Jussi Hepojoki, Ari Pekka Huovila, Kalle Saksela

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121301 (2015)

A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a s

Externí odkaz: https://doaj.org/article/17bd5e2928b447b8bf265eaaa528e612

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Akademický článek

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain.

Autor: Annika Järviluoma, Tomas Strandin, Sebastian Lülf, Jérôme Bouchet, Anna R Mäkelä, Matthias Geyer, Serge Benichou, Kalle Saksela

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40331 (2012)

Monoclonal and recombinant antibodies are ubiquitous tools in diagnostics, therapeutics, and biotechnology. However, their biochemical properties lack optimal robustness, their bacterial production is not easy, and possibilities to create multifuncti

Externí odkaz: https://doaj.org/article/f5d5bb140c814e85a52a5463f9b77ddf

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Akademický článek

Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency.

Autor: Grzegorz Sarek, Annika Järviluoma, Henna M Moore, Sari Tojkander, Salla Vartia, Peter Biberfeld, Marikki Laiho, Päivi M Ojala

Publikováno v: PLoS Pathogens, Vol 6, Iss 3, p e1000818 (2010)

Nucleophosmin (NPM) is a multifunctional nuclear phosphoprotein and a histone chaperone implicated in chromatin organization and transcription control. Oncogenic Kaposi's sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma, primar

Externí odkaz: https://doaj.org/article/fde858a70594489799a0ec0cfa14078d

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KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

Autor: Emmy W. Verschuren, Pirita Pekkonen, Anna Cvrljevic, Nadezhda Zinovkina, Annika Järviluoma, Päivi M. Ojala, Sonam Prakash, Jukka Westermarck, Gerard I. Evan, Ethel Cesarman

Publikováno v: Cell Cycle
Europe PubMed Central

Kaposi's sarcoma herpesvirus (KSHV)-encoded v-cyclin, a homolog of cellular cyclin D2, activates cellular CDK6, promotes G1-S transition of the cell cycle, induces DNA damage, apoptosis, autophagy and is reported to have oncogenic potential. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2b2091b96a82f836fb353c2514c87b
http://europepmc.org/articles/PMC4613844

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Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions

Autor: Isabelle Maridonneau-Parini, Salomeh Rafie, Kalle Saksela, Serge Benichou, Julie Mazzolini, Daniel Baty, Christel Vérollet, Patrick Chames, Jérôme Bouchet, Carolin A. Guenzel, Florence Niedergang, Cécile Hérate, Annika Järviluoma

Publikováno v: Journal of Virology. 86:4856-4867

HIV-1 Nef is essential for AIDS pathogenesis, but this viral protein is not targeted by antiviral strategies. The functions of Nef are largely related to perturbations of intracellular trafficking and signaling pathways through leucine-based and poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e68c2ecfc0aa3f99fa0ad7c626343ba
https://doi.org/10.1128/jvi.06329-11

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Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis

Autor: Päivi M. Ojala, Pawan Pyakurel, Annika Järviluoma, Johanna Furuhjelm, Marikki Laiho, Maria Wirzenius, Sari Jäämaa, Christel Pussinen, Peter Biberfeld, Kari Alitalo, Sonja Koopal

Publikováno v: PLoS Pathogens, Vol 3, Iss 9, Pp 1348-1360 (2007)
PLoS Pathogens

Kaposi sarcoma is a tumor consisting of Kaposi sarcoma herpesvirus (KSHV)–infected tumor cells that express endothelial cell (EC) markers and viral genes like v-cyclin, vFLIP, and LANA. Despite a strong link between KSHV infection and certain neopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1445e1e8faeb298c28ad5675bb5601b6
https://doaj.org/article/2f23eda7c9764a07baabb81a431641b6

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Cell signaling pathways engaged by KSHV

Autor: Annika Järviluoma, Päivi M. Ojala

Publikováno v: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1766:140-158

Kaposi's sarcoma herpesvirus (KSHV) is the eighth human herpesvirus discovered in 1994 from Kaposi's sarcoma lesion of an AIDS patient. The strong molecular and epidemiological links associating KSHV with Kaposi's sarcoma and certain lymphoproliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e36affa5301b7487b54ebca2538c812
https://doi.org/10.1016/j.bbcan.2006.05.001

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Preferred SH3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-Specific SH3 Interactions

Autor: Ari-Pekka J. Huovila, Iivari Kleino, Jussi Hepojoki, Annika Järviluoma, Kalle Saksela

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0121301 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3d7a2132b8b16d3e172f31b778bcbd
https://trepo.tuni.fi/handle/10024/96898

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Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

Autor: Kalle Saksela, Serge Benichou, Sebastian Lülf, Julie Matz, Annika Järviluoma, Matthias Geyer, Marie-Christine Rouyez

Publikováno v: Retrovirology
Retrovirology, BioMed Central, 2014, 11 (1), pp.24. ⟨10.1186/1742-4690-11-24⟩
Retrovirology, 2014, 11 (1), pp.24. ⟨10.1186/1742-4690-11-24⟩
Retrovirology, BioMed Central, 2014, 11 (1), pp.24. 〈10.1186/1742-4690-11-24〉

International audience; BackgroundThe HIV-1 Nef protein is essential for AIDS pathogenesis by its interaction with host cell surface receptors and signaling factors. Despite its critical role as a virulence factor Nef is not targeted by current antiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6250a113c398988186697c611becf741
https://www.hal.inserm.fr/inserm-00980901/document

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