Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Annika Dhawan"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
In the US, there are ~250,000 new lung cancer diagnoses and ~130,000 deaths per year, and worldwide there are an estimated 1.6 million deaths per year from this deadly disease. Lung cancer is the most common cause of cancer death worldwide, and it ac
Externí odkaz:
https://doaj.org/article/203cac6cf9934343b84723ffd84e2cfd
Autor:
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acet
Externí odkaz:
https://doaj.org/article/9e9b057abf944363949c648ff88a38f3
Autor:
Heath D. Skinner, Raymond E. Meyn, Curtis R. Pickering, Kathryn A. Mason, Howard D. Thames, Beth M. Beadle, Aakash Sheth, Vlad Sandulache, Phillip M. Pifer, Mohamed Abdelhakiem, Liangpeng Yang, Manish Kumar, Andrew J. Hefner, Reshub Bahri, Annika Dhawan, David R. Valdecanas, Kathleen A. Bridges, Jessica M. Molkentine, David P. Molkentine
Supplementary Data from p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5a277048ff4f3713318e86b43be1de
https://doi.org/10.1158/0008-5472.22431283.v1
https://doi.org/10.1158/0008-5472.22431283.v1
Autor:
Heath D. Skinner, Raymond E. Meyn, Curtis R. Pickering, Kathryn A. Mason, Howard D. Thames, Beth M. Beadle, Aakash Sheth, Vlad Sandulache, Phillip M. Pifer, Mohamed Abdelhakiem, Liangpeng Yang, Manish Kumar, Andrew J. Hefner, Reshub Bahri, Annika Dhawan, David R. Valdecanas, Kathleen A. Bridges, Jessica M. Molkentine, David P. Molkentine
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensitive to radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9959bb71a691ecc3132dd0d64975f6
https://doi.org/10.1158/0008-5472.c.6513859.v1
https://doi.org/10.1158/0008-5472.c.6513859.v1
Autor:
David P. Molkentine, Jessica M. Molkentine, Kathleen A. Bridges, David R. Valdecanas, Annika Dhawan, Reshub Bahri, Andrew J. Hefner, Manish Kumar, Liangpeng Yang, Mohamed Abdelhakiem, Phillip M. Pifer, Vlad Sandulache, Aakash Sheth, Beth M. Beadle, Howard D. Thames, Kathryn A. Mason, Curtis R. Pickering, Raymond E. Meyn, Heath D. Skinner
Publikováno v:
Cancer Res
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies than its HPV-negative counterpart. Here, we show that p16, the clinically used surrogate for HPV positivity, renders cells more sensitive to radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094cf9460697a73cf9a44a961d3b54a2
https://doi.org/10.1158/0008-5472.can-21-2101
https://doi.org/10.1158/0008-5472.can-21-2101
Autor:
Phillip M. Pifer, Liangpeng Yang, Manish Kumar, Tongxin Xie, Mitchell Frederick, Andrew Hefner, Beth Beadle, David Molkentine, Jessica Molkentine, Annika Dhawan, Mohamed Abdelhakiem, Abdullah A. Osman, Jeffrey N. Myers, Curtis R. Pickering, Vlad C. Sandulache, John Heymach, Heath D. Skinner
Radiation and platinum-based chemotherapy form the backbone of therapy in HPV-negative head and neck squamous cell carcinoma (HNSCC). We have correlated focal adhesion kinase (FAK/PTK2) expression with radioresistance and worse outcome in these patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c32c70371d0c59e57aad6acc4e2bf0c
https://doi.org/10.1101/2022.06.03.494547
https://doi.org/10.1101/2022.06.03.494547
Autor:
Reshub Bahri, Annika Dhawan, Liangpeng Yang, Li Shen, Jessica M. Molkentine, Andrew J. Hefner, Jing Wang, Robert L. Ferris, Beth M. Beadle, Meng Gao, Kathleen Bridges, Mohamed Abdelhakiem, Aakash Sheth, Manish Kumar, Sahil Seth, Heath D Skinner, Faye M. Johnson, Jeffrey N. Myers, Curtis R. Pickering, Timothy P. Heffernan, Tongxin Xie, David Molkentine, Mitchell J. Frederick
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally associated with radiation response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d0fbc54e6849ef9f4b8260ed195d92
https://pubmed.ncbi.nlm.nih.gov/34732714
https://pubmed.ncbi.nlm.nih.gov/34732714
Autor:
Harry Williams, Abhijit Kulkarni, Anthony Lupetin, Shyam Thakkar, Dulabh Monga, Marcia Mitre, Manish Dhawan, Gursimran Kochhar, Gurneet Bedi, Alexander V. Kirichenko, Annika Dhawan, Zachary D. Horne, Suzanne Schiffman, Aslam Syed, Suzanne Morrissey, Donald Atkinson, Neil M. Carleton
Publikováno v:
Journal of gastrointestinal cancer. 51(3)
Despite advances in various treatment modalities, surgical resection for pancreatic ductal adenocarcinoma (PDA) remains the only curative treatment. Data remains limited regarding survival rates for resectable PDA when managed by a multidisciplinary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15fb6df08c19007680717d48595ceca
https://pubmed.ncbi.nlm.nih.gov/31605289
https://pubmed.ncbi.nlm.nih.gov/31605289
Publikováno v:
American Journal of Gastroenterology. 114:S319-S320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91ea930b53fe44f342ac716ab61e7f62
https://doi.org/10.14309/01.ajg.0000591748.88009.8a
https://doi.org/10.14309/01.ajg.0000591748.88009.8a
Publikováno v:
American Journal of Gastroenterology. 113:S26-S27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2058b4613cecf9f7a20c3f479aa854
https://doi.org/10.14309/00000434-201810001-00043
https://doi.org/10.14309/00000434-201810001-00043