Peptide–Fluorophore Hydrogel as a Signal Boosting Approach in Rapid Detection of Cancer DNA

Autor: Bernhard Jandl, Sima Sedghiniya, Annika Carstens, Kira Astakhova

Publikováno v: ACS Omega, Vol 4, Iss 9, Pp 13889-13895 (2019)

Externí odkaz: https://doaj.org/article/d65af29200de42e1ac94de88de82f42e

'Clicking' Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions

Autor: Roslyn M. Ray, Kevin V. Morris, Kira Astakhova, Annika Carstens, Jesper Uhd, Maria Taskova

Publikováno v: Astakhova, K, Ray, R, Taskova, M, Uhd, J, Carstens, A & Morris, K 2018, ' "Clicking" Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions ', Molecular Pharmaceutics, vol. 15, no. 8, pp. 2892-2899 . https://doi.org/10.1021/acs.molpharmaceut.7b00765

The use of nucleic acid, DNA and RNA, based strategies to disrupt gene expression as a therapeutic is quickly emerging. Indeed, synthetic oligonucleotides represent a major component of emerging gene therapeutics. However, the efficiency and specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3af597f4997f27b60c0a1e827cbb45
https://doi.org/10.1021/acs.molpharmaceut.7b00765

Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies

Autor: Christoffer Tandrup Nielsen, Jørgen Kjems, Niels H. H. Heegaard, Anders H. Okholm, Kira Astakhova, Ivana Domljanovic, Annika Carstens

Publikováno v: Domljanovic, I, Carstens, A, Okholm, A, Kjems, J, Nielsen, C T, Heegaard, N H H & Astakhova, K 2017, ' Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies ', Scientific Reports, vol. 7, 1925 . https://doi.org/10.1038/s41598-017-02214-0
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Domljanovic, I, Carstens, A, Okholm, A H, Kjems, J, Nielsen, C T, Heegaard, N H H & Astakhova, K 2017, ' Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies ', Scientific Reports, vol. 7, 1925 . https://doi.org/10.1038/s41598-017-02214-0

To date, there are multiple assays developed that detect and quantify antibodies in biofluids. Nevertheless, there is still a lack of simple approaches that specifically detect autoimmune antibodies to double-stranded DNA. Herein we investigate the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5cbfce52d1827b0dfefae1a88b8e34
https://doi.org/10.1038/s41598-017-02214-0