Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Annika C. Betzler"'
Autor:
Tsima Abou Kors, Matthias Meier, Lena Mühlenbruch, Annika C. Betzler, Franziska Oliveri, Martin Bens, Jaya Thomas, Johann M. Kraus, Johannes Doescher, Adrian von Witzleben, Linda Hofmann, Jasmin Ezic, Diana Huber, Julian Benckendorff, Thomas F. E. Barth, Jens Greve, Patrick J. Schuler, Cornelia Brunner, Jonathan M. Blackburn, Thomas K. Hoffmann, Christian Ottensmeier, Hans A. Kestler, Hans-Georg Rammensee, Juliane S. Walz, Simon Laban
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T cells. Overexpressed tumor associated antigens, mainly cancer-testis antigens (CTA)
Externí odkaz:
https://doaj.org/article/395296b0c62b42a7af04bb14da175331
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/54b4c77185e8488a949dfeae77529985
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the tumor milieu of head and neck squamous cell carcinoma (HNSCC), distinct B cell subpopulations are present, which exert either pro- or anti-tumor activities. Multiple factors, including hypoxia, cytokines, interactions with tumor cells, and oth
Externí odkaz:
https://doaj.org/article/2fdc2fe898464d04b122178442123545
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The germinal center (GC) reaction is a key process during an adaptive immune response to T cell specific antigens. GCs are specialized structures within secondary lymphoid organs, in which B cell proliferation, somatic hypermutation and antibody affi
Externí odkaz:
https://doaj.org/article/55ebb4d04f424abda17ff4eadfdfd995
Autor:
Annika C. Betzler, Jasmin Ezić, Tsima Abou Kors, Thomas K. Hoffmann, Thomas Wirth, Cornelia Brunner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the complete absence of germinal centers (GCs). This defect was mainly attributed to the defective
Externí odkaz:
https://doaj.org/article/cd50db055ba54440964af69597aaba3b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/bf2d084e6cc141d69a489462362e6b57
Autor:
Annika C. Betzler, Sebastian Kieser, Katja Fiedler, Simon Laban, Marie-Nicole Theodoraki, Patrick J. Schuler, Thomas Wirth, Kerry Tedford, Klaus-Dieter Fischer, Thomas K. Hoffmann, Cornelia Brunner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Btk and Vav proteins are all components of the signalosome that builds upon B cell receptor (BCR) activation. However, the role of Vav proteins within the signalosome is quite complex and not yet fully understood. Until now, studies of these have foc
Externí odkaz:
https://doaj.org/article/0c03eaa83f2e4a4ab5ae78c0b4bca5dc
Autor:
Annika C. Betzler, Hannah Strobel, Tsima Abou Kors, Jasmin Ezić, Kristina Lesakova, Ronja Pscheid, Ninel Azoitei, Johanna Sporleder, Anna-Rebekka Staufenberg, Robert Drees, Stephanie E. Weissinger, Jens Greve, Johannes Doescher, Marie-Nicole Theodoraki, Patrick J. Schuler, Simon Laban, Toshiro Kibe, Michiko Kishida, Shosei Kishida, Christian Idel, Thomas K. Hoffmann, Marialuisa Lavitrano, Emanuela Grassilli, Cornelia Brunner
Publikováno v:
Cancers; Volume 15; Issue 1; Pages: 310
Here, we describe the expression of Bruton’s Tyrosine Kinase (BTK) in head and neck squamous cell carcinoma (HNSCC) cell lines as well as in primary HNSCC samples. BTK is a kinase initially thought to be expressed exclusively in cells of hematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067b47e8094518dc123c0fafb62814d2
https://hdl.handle.net/10281/402357
https://hdl.handle.net/10281/402357
Autor:
Annika C. Betzler, Katja Fiedler, Thomas K. Hoffmann, Hans Joerg Fehling, Thomas Wirth, Cornelia Brunner
Publikováno v:
European Journal of Immunology. 52:404-417
BOB.1/OBF.1 is a lymphocyte-specific transcriptional co-activator of octamer-dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct-1 and Oct-2 transcription factors. So far, BOB.1/OBF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad3ff90b20c5d99e99127a96a7cd61a
https://doi.org/10.1002/eji.202149333
https://doi.org/10.1002/eji.202149333
Autor:
Thomas Wirth, Thomas K. Hoffmann, Cornelia Brunner, Annika C Betzler, Katja Fiedler, Enikö Kokai
Publikováno v:
European Journal of Immunology. 51:1860-1863
BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13-CXCR5 signaling of LTinducer and LTorganizer cells during embryonic Peyer's patch organogenesis as well as of B cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea8a7d19bd53b68f452203bbaf0a4d3
https://doi.org/10.1002/eji.202048578
https://doi.org/10.1002/eji.202048578