Výsledky vyhledávání - "Annika Allqvist"

Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers

Autor: Jun Miura, Leif Bertilsson, Annika Allqvist, Rajaa A. Mirghani

Publikováno v: European Journal of Clinical Pharmacology. 63:173-179

The antifungal drug ketoconazole (KTZ) is known as an inhibitor of, especially, the CYP3A subfamily, which catalyzes the metabolism of a large variety of drugs. Interactions between KTZ and CYP3A substrates have been reported both in vivo and in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67312c54ac81156389d81abec7256325
https://doi.org/10.1007/s00228-006-0230-z

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Simultaneous quantification of alprazolam, 4- and α-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry

Autor: Jan-Olof Svensson, Annika Allqvist, Agneta Wennerholm, Rajaa A. Mirghani

Publikováno v: Journal of Chromatography B. 814:127-131

A sensitive and specific method was developed for quantification of alprazolam and its two metabolites 4-hydroxyalprazolam and α-hydroxyalprazolam in plasma. The work up procedure was solid phase extraction. Liquid chromatography–mass spectrometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30e6c6c995e981622c5770a068907aa
https://doi.org/10.1016/j.jchromb.2004.10.012

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CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

Autor: Barry C Jones, Mary Jande, Lars L. Gustafsson, Annika Allqvist, Agneta Wennerholm, Rajaa A. Mirghani, Jaran Eriksen, Leif Bertilsson, Eleni Aklillu, Virginie M M Herben, Jane Sayi

Publikováno v: Karolinska Institutet

To study the correlation between CYP3A5 genotype and quinine 3-hydroxylation in black Tanzanian and Swedish Caucasians as well as to investigate the interethnic differences in CYP3A activity between the two populations.Tanzanian (n=144) and Swedish (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b180fcdd350b98603143aca13d72a7e
https://pubmed.ncbi.nlm.nih.gov/16906018

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Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects

Autor: Leif Bertilsson, Jan-Olof Svensson, Rajaa A. Mirghani, Lars L. Gustafsson, Annika Allqvist, Agneta Wennerholm

Publikováno v: European journal of clinical pharmacology. 61(2)

(1) To determine the pharmacokinetic parameters of alprazolam and its two metabolites in plasma from healthy volunteers; (2) to identify a suitable single time point to take a plasma sample for CYP3A phenotyping.Twelve healthy Swedish volunteers rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4316f4d6387617fa2893ab153375634c
https://pubmed.ncbi.nlm.nih.gov/15806426

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