Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Annika, Nerstedt"'
Autor:
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Blüher, Annika Nerstedt, Ulf Smith
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and aging increases the burden of CS in all major metabolic tissues. However, CS is also increased in adult obesity, type 2 diabetes (T2D), and nonalcoholic fatty li
Externí odkaz:
https://doaj.org/article/385566925a69478882f3d28fa1bafa44
Autor:
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez-Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, Darren N. Saunders, Carina Sihlbom, Andrew J. Hoy, Margit Mahlapuu
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 178-191 (2020)
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of the major unmet medical needs of the 21st century. Our recent translational
Externí odkaz:
https://doaj.org/article/5223ec8bf7604ecfadc7de925c7c5dab
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Adipose tissue hypertrophy in obesity is associated with insulin resistance and other metabolic complications. Here, the authors analyze subcutaneous adipose tissue from patients with hypertrophic obesity and insulin resistance and find that adipocyt
Externí odkaz:
https://doaj.org/article/a5de7224b22546db86b2f0bcdb112ada
Autor:
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://doaj.org/article/76ee7c613d244adda29bbfe316fe4d15
Autor:
Adil Mardinoglu, Silvia Gogg, Luca A. Lotta, Alena Stančáková, Annika Nerstedt, Jan Boren, Matthias Blüher, Ele Ferrannini, Claudia Langenberg, Nicholas J. Wareham, Markku Laakso, Ulf Smith
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 151-155 (2018)
Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if 3-HIB is a marker of h
Externí odkaz:
https://doaj.org/article/aee5dd5f2193492fb79561f21ba0245e
Autor:
Annika Nerstedt, Ulf Smith
Publikováno v:
Journal of Cell Communication and Signaling.
In the last decades the prevalence of obesity has increased dramatically, and the worldwide epidemic of obesity and related metabolic diseases has contributed to an increased interest for the adipose tissue (AT), the primary site for storage of lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9be677811dde4b7cb224f1af0a9ce94
https://doi.org/10.1007/s12079-023-00769-4
https://doi.org/10.1007/s12079-023-00769-4
Autor:
Rosa Spinelli, Pasqualina Florese, Luca Parrillo, Federica Zatterale, Michele Longo, Vittoria D’Esposito, Antonella Desiderio, Annika Nerstedt, Birgit Gustafson, Pietro Formisano, Claudia Miele, Gregory Alexander Raciti, Raffaele Napoli, Ulf Smith, Francesco Beguinot
Publikováno v:
Aging Cell. 21
Senescence of adipose precursor cells (APC) impairs adipogenesis, contributes to the age-related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 diabetes (T2D). First-degree relatives of T2D individuals (FDR) feature restr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184466bf7670c38fe470dee09c5319f5
https://doi.org/10.1111/acel.13557
https://doi.org/10.1111/acel.13557
Obesity with dysfunctional adipose cells is the major cause of the current epidemic of type 2 diabetes (T2D). We examined senescence in human adipose tissue cells from age- and BMI-matched individuals who were lean, obese, and obese with T2D. In obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f4956a4e9d64dca1fd3d8ed6350319
https://hdl.handle.net/11588/892646
https://hdl.handle.net/11588/892646
Autor:
Carina Sihlbom, Marcus Ståhlman, Margit Mahlapuu, Annika Nerstedt, Emmelie Cansby, Jan Borén, Hanns-Ulrich Marschall, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Matthias Blüher
Publikováno v:
The FASEB Journal. 33:9974-9989
Ectopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks controlling hepatocellular lipid deposition is therefore essential for developing new strategies to ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3c87591f464adbc20146d73c269e0d
https://doi.org/10.1096/fj.201900356rr
https://doi.org/10.1096/fj.201900356rr
Autor:
Mara Caputo, Emmelie Cansby, Paolo Parini, Lei Gao, Matteo Pedrelli, Rando Porosk, Nagaraj M. Kulkarni, Jan Borén, Marcus Ståhlman, Ursel Soomets, Margit Mahlapuu, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Annika Nerstedt
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6405fed100f26e20445e18e5e7e4e1
http://europepmc.org/articles/PMC7819747
http://europepmc.org/articles/PMC7819747