Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Annik, Prat"'
Autor:
Carole Fruchart Gaillard, Ali Ben Djoudi Ouadda, Lidia Ciccone, Emmanuelle Girard, Sepideh Mikaeeli, Alexandra Evagelidis, Maïlys Le Dévéhat, Delia Susan-Resiga, Evelyne Cassar Lajeunesse, Hervé Nozach, Oscar Henrique Pereira Ramos, Aurélien Thureau, Pierre Legrand, Annik Prat, Vincent Dive, Nabil G. Seidah
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101662- (2023)
Objective: The liver-derived circulating PCSK9 enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes. PCSK9 inhibition or silencing is presently used in clinics worldwide to reduce LDL-cholesterol, resulting in lower incidence of
Externí odkaz:
https://doaj.org/article/25b8b2644d1147d09b7ec706733b10c7
Autor:
Justin R. Clark, Matthew Gemin, Amer Youssef, Santica M. Marcovina, Annik Prat, Nabil G. Seidah, Robert A. Hegele, Michael B. Boffa, Marlys L. Koschinsky
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100216- (2022)
Elevated plasma lipoprotein(a) (Lp(a)) is an independent, causal risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Lp(a) is formed in or on hepatocytes from successive noncovalent and covalent interactions bet
Externí odkaz:
https://doaj.org/article/781c7995a9834511ab3aa887d2fece44
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The PCSK9 contribution to cholesterol and immunotolerance homeostasis and response to glucose, and insulin in testis and hypophysis were studied using Pcsk9-deficient (−/−) and transgenic [Tg (PCSK9)] mice, and diabetic, obese ob/ob and db/db mic
Externí odkaz:
https://doaj.org/article/7cd333e517c8408e98cc063a5f5cd116
Autor:
François Moreau, Aurélie Thédrez, Damien Garçon, Audrey Ayer, Thibaud Sotin, Wieneke Dijk, Claire Blanchard, Gilliane Chadeuf, Lucie Arnaud, Mikael Croyal, Laurianne Van Landeghem, Melissa Touvron, Xavier Prieur, Anna Roubtsova, Nabil Seidah, Annik Prat, Bertrand Cariou, Cedric Le May
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100186- (2022)
Externí odkaz:
https://doaj.org/article/730a97c1136947c4a4d75097c5285770
Autor:
Paul F. Lebeau, Jae Hyun Byun, Khrystyna Platko, Ali A. Al-Hashimi, Šárka Lhoták, Melissa E. MacDonald, Aurora Mejia-Benitez, Annik Prat, Suleiman A. Igdoura, Bernardo Trigatti, Kenneth N. Maclean, Nabil G. Seidah, Richard C. Austin
Publikováno v:
JHEP Reports, Vol 1, Iss 6, Pp 418-429 (2019)
Background & Aims: The fatty acid translocase, also known as CD36, is a well-established scavenger receptor for fatty acid (FA) uptake and is abundantly expressed in many metabolically active tissues. In the liver, CD36 is known to contribute to the
Externí odkaz:
https://doaj.org/article/bc29e44a6d4f455ca1909cd11dae2193
Autor:
Moreau François, Aurélie Thédrez, Damien Garçon, Audrey Ayer, Thibaud Sotin, Wieneke Dijk, Claire Blanchard, Gilliane Chadeuf, Lucie Arnaud, Mikael Croyal, Laurianne Van Landeghem, Melissa Touvron, Xavier Prieur, Anna Roubtsova, Nabil Seidah, Annik Prat, Bertrand Cariou, Cedric Le May
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100096- (2021)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes lysosomal degradation of the LDL receptor and is a key regulator of cholesterol metabolism. After the liver, the small intestine is the second organ that highly expresses PCSK9. However,
Externí odkaz:
https://doaj.org/article/4b79941b5e7e491798dd4c76fba5ae54
Autor:
Nabil Seidah, Vatsal Sachan, Mailys Le Dévéhat, Anna Roubtsova, Rachid Essalmani, Damien Garçon, Delia Susan-Resiga, Stéphanie Duval, Sahar Mikaeeli, Josée Hamelin, Alexandra Evagelidis, Michael Chong, Guillaume Pare, Elizabeta Chernetsova, Zu-hua Gao, Isabelle Robillard, Matthieu Ruiz, Vincent Quoc-Huy Trinh, Jennifer Estall, May Faraj, Jean-Francois Laurendeau, Richard Austin, Martin Sauvageau, Annik Prat, Robert Scott Kiss
Epidemiological evidence links the proprotein convertase subtilisin/kexin 7 (PCSK7) to triglyceride (TG) metabolism. PCSK7-SNPs gain-of-function and loss-of-function variants were associated with higher and lower levels of plasma apoB and TGs, respec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7611159c671b9f23fc40d49502551155
https://doi.org/10.21203/rs.3.rs-2724841/v1
https://doi.org/10.21203/rs.3.rs-2724841/v1
Autor:
Annik Prat, Nabil G. Seidah
Publikováno v:
Endocrine Reviews. 43:558-582
This article reviews the discovery of PCSK9, its structure–function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f057c24495f9d6fe03aba2b9c272ed7
https://doi.org/10.1210/endrev/bnab035
https://doi.org/10.1210/endrev/bnab035
Autor:
Anna Roubtsova, Ann Chamberland, Jadwiga Marcinkiewicz, Rachid Essalmani, Ali Fazel, John J. Bergeron, Nabil G. Seidah, Annik Prat
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2133-2142 (2015)
Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Her
Externí odkaz:
https://doaj.org/article/2d75aa1c6d82491d82b7d93c296d5cb5
Autor:
Anna Roubtsova, Corey A. Scipione, Damien Garçon, Michael B. Boffa, Nabil G. Seidah, Marlys L. Koschinsky, Annik Prat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1868:159288
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf4092a41fb81d72cbeaf20f80069ef
https://doi.org/10.1016/j.bbalip.2023.159288
https://doi.org/10.1016/j.bbalip.2023.159288