Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anniina Raitila"'
Autor:
Elina Heliövaara, Sampsa Hautaniemi, Leena Kivipelto, I. Tuominen, M-R Rautiainen, Riku Katainen, V. Aittomaki, Anniina Raitila, Miika Mehine, Auli Karhu, Camilla Schalin-Jäntti, Manuel Ahlsten, Heli J. Lehtonen, Iikki Donner, Johanna Arola
Publikováno v:
Oncogene. 34:1174-1184
The aryl hydrocarbon receptor interacting protein (AIP) is a tumor-suppressor gene underlying the pituitary adenoma predisposition. Thus far, the exact molecular mechanisms by which inactivated AIP exerts its tumor-promoting action have been unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29df03a3707f72f51ea9c820fb583e69
https://doi.org/10.1038/onc.2014.50
https://doi.org/10.1038/onc.2014.50
Autor:
Raquel Seruca, Pia Alhopuro, Jani Puhakka, Lauri A. Aaltonen, Juha Saharinen, Mia Bistrom, Ana Ferreira, Robert M.W. Hofstra, Heikki Järvinen, Sari Tuupanen, Ari Ristimäki, Heli Sammalkorpi, Auli Karhu, Elina Heliövaara, Diego Arango, Jukka-Pekka Mecklin, Torben F. Ørntoft, Iina Niittymäki, Heli J. Lehtonen, Anniina Raitila, Kari Nousiainen, Sónia Sousa, Sampsa Hautaniemi
Publikováno v:
Alhopuro, P, Sammalkorpi, H, Niittymäki, I, Biström, M, Raitila, A, Saharinen, J, Nousiainen, K, Lehtonen, H J, Heliövaara, E, Puhakka, J, Tuupanen, S, Sousa, S, Seruca, R, Ferreira, A M, Hofstra, R M W, Mecklin, J-P, Järvinen, H, Ristimäki, A, Orntoft, T F, Hautaniemi, S, Arango, D, Karhu, A & Aaltonen, L A 2012, ' Candidate driver genes in microsatellite-unstable colorectal cancer ', International Journal of Cancer, vol. 130, no. 7, pp. 1558-1566 . https://doi.org/10.1002/ijc.26167
International Journal of Cancer, 130(7), 1558-1566. Wiley
International Journal of Cancer, 130(7), 1558-1566. Wiley
Defects in the mismatch repair system lead to microsatellite instability (MSI), a feature observed in ∼ 15% of all colorectal cancers (CRCs). Microsatellite mutations that drive tumourigenesis, typically inactivation of tumour suppressors, are sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d0ae9a058f2268e259334336faaa42
https://hdl.handle.net/11370/92e6df77-237a-4c70-a9db-be5f06238e4c
https://hdl.handle.net/11370/92e6df77-237a-4c70-a9db-be5f06238e4c
Autor:
Marianthi Georgitsi, Heli J. Lehtonen, Anu Jalanko, Elina Heliövaara, Manuel Ahlsten, Johanna Arola, Lauri A. Aaltonen, Anniina Raitila, Anders Paetau, Auli Karhu
Publikováno v:
The American Journal of Pathology. 177:1969-1976
Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been shown to predispose to pituitary adenoma predisposition, a condition characterized by growth hormone (GH)-secreting pituitary tumors. To study AIP-mediated tumorigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22bc17c9e0f65bc4ac392ede2c038c7
https://doi.org/10.2353/ajpath.2010.100138
https://doi.org/10.2353/ajpath.2010.100138
Autor:
Outi Vierimaa, Andrea Villablanca, Jaakko Ignatius, Lauri A. Aaltonen, J. Leisti, Anniina Raitila, Marianthi Georgitsi, Tapani Ebeling, Catharina Larsson, Aimo Ruokonen, Pasi I. Salmela, Andrei Alimov, Pia Vahteristo, E. Eloranta
Publikováno v:
Journal of Endocrinological Investigation. 32:512-518
Objective: Primary hyperparathyroidism (PHPT), a common endocrine condition, is usually caused by sporadically occurring parathyroid adenoma. A subset of patients carry germline mutations in genes such as MEN1 (multiple endocrine neoplasia type 1), H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee485ed66a37fd26c3a9c8be0dfe4094
https://doi.org/10.1007/bf03346498
https://doi.org/10.1007/bf03346498
Autor:
Virpi Launonen, Pia Vahteristo, Marianna Georgitsi, Anniina Raitila, Torben F. Ørntoft, Kaisa Salmenkivi, Lauri A. Aaltonen, Markus J. Mäkinen, Johanna Arola, Karoliina Tuppurainen, Karin Birkenkamp-Demtröder, Auli Karhu
Publikováno v:
Raitila, A, Georgitsi, M, Karhu, A, Tuppurainen, K, Mäkinen, M J, Birkenkamp-Demtröder, K, Salmenkivi, K, Orntoft, T F, Arola, J, Launonen, V, Vahteristo, P & Aaltonen, L A 2007, ' No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia ', Endocrine-Related Cancer, vol. 14, no. 3, pp. 901-6 . https://doi.org/10.1677/ERC-07-0025
A, R, Georgitsi, M, Karhu, A, Tuppurainen, K, Mäkinen, M, Birkenkamp-Demtröder, K, Salmenkivi, K, Ørntoft, T F, Arola, J, Launonen, V, Vahteristo, P & Aaltonen, L A 2007, ' No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia ', Endocrine-Related Cancer, vol. 14, no. 3, pp. 901-906 . https://doi.org/10.1677/ERC-07-0025
A, R, Georgitsi, M, Karhu, A, Tuppurainen, K, Mäkinen, M, Birkenkamp-Demtröder, K, Salmenkivi, K, Ørntoft, T F, Arola, J, Launonen, V, Vahteristo, P & Aaltonen, L A 2007, ' No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia ', Endocrine-Related Cancer, vol. 14, no. 3, pp. 901-906 . https://doi.org/10.1677/ERC-07-0025
Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene were recently observed in patients with pituitary adenoma predisposition (PAP). Though AIP mutation-positive individuals with prolactin-, mixed growth hormone/prolacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629de6bcd34eca6dc351d29074b5abd3
https://doi.org/10.1677/erc-07-0025
https://doi.org/10.1677/erc-07-0025
Autor:
Olga Lucewicz, A. Wasik, Jan Lubinski, Pia Vahteristo, Wolfgang Saeger, Virpi Launonen, Outi Vierimaa, Anniina Raitila, Marianthi Georgitsi, Mercedes Robledo, Auli Karhu, Grzegorz Zieliński, Ernesto De Menis, Timo Sane, Rob B. van der Luijt, Lauri A. Aaltonen, Markus J. Mäkinen, Karoliina Tuppurainen, Robert J. Weil, Ralf Paschke
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4101-4105
Pituitary adenomas are common neoplasms of the anterior pituitary gland. Germ-line mutations in the aryl hydrocarbon receptor-interacting protein ( AIP ) gene cause pituitary adenoma predisposition (PAP), a recent discovery based on genetic studies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046570db4f11144675025a2af6c125ef
https://doi.org/10.1073/pnas.0700004104
https://doi.org/10.1073/pnas.0700004104
Autor:
Virpi Launonen, Shirley Hodgson, Ralph Paschke, Marc Tischkowitz, Timo Sane, Gul Bano, Outi Vierimaa, Marianthi Georgitsi, Oliver Gimm, Lauri A. Aaltonen, Rob B. van der Luijt, Markus J. Mäkinen, Cora M. Aalfs, Simon Aylwin, Karoliina Tuppurainen, Anneke Lucassen, Christian A. Koch, Anniina Raitila, Pia Vahteristo, Sadi Gundogdu, Ernesto De Menis, Auli Karhu, Louise Izatt
Publikováno v:
Journal of clinical endocrinology and metabolism, 92(8), 3321-3325. The Endocrine Society
Context: Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome, but in up to 20–25% of clinical MEN1 cases, no MEN1 mutations can be found. Recently, a germline mutation in the CDKN1B gene, encoding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb22fe6fef98c1ac986ed8c79ca2bdfd
https://doi.org/10.1210/jc.2006-2843
https://doi.org/10.1210/jc.2006-2843
Autor:
Tapani Ebeling, Outi Vierimaa, Lauri A. Aaltonen, Markus J. Mäkinen, Marianthi Georgitsi, Sadi Gundogdu, Virpi Launonen, Karoliina Tuppurainen, Rainer Lehtonen, Anniina Raitila, Pia Vahteristo, Ralf Paschke, Ernesto De Menis, Antti Kokko, Pasi I. Salmela, Auli Karhu
Publikováno v:
Science. 312:1228-1230
Pituitary adenomas are common in the general population, and understanding their molecular basis is of great interest. Combining chip-based technologies with genealogy data, we identified germline mutations in the aryl hydrocarbon receptor interactin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc628a6717c34c0dda96652d876d3318
https://doi.org/10.1126/science.1126100
https://doi.org/10.1126/science.1126100
Autor:
Virpi Launonen, Lauri A. Aaltonen, Anniina Raitila, Robert J. Weil, Elina Heliövaara, Timo Sane, Anders Paetau, Markus J. Mäkinen, Pasi I. Salmela, Auli Karhu, Karoliina Tuppurainen, Heli J. Lehtonen, Outi Vierimaa, Johanna Arola
Publikováno v:
The American journal of pathology. 175(6)
Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to the development of pituitary adenomas. Here, we characterized AIP mutation positive (AIPmut+) and AIP mutation negative (AIPmut-) pituitary adenomas by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d8662903347a9cb7dbb20e9c02d594
https://pubmed.ncbi.nlm.nih.gov/19850893
https://pubmed.ncbi.nlm.nih.gov/19850893
Autor:
Manuela Vargiolu, Pia Vahteristo, Outi Vierimaa, Virpi Launonen, Markus J. Mäkinen, Marianthi Georgitsi, Lauri A. Aaltonen, Auli Karhu, Giovanni Romeo, Anniina Raitila, Karoliina Tuppurainen, Pasi I. Salmela, Elena Bonora
Publikováno v:
Scopus-Elsevier
University of Helsinki
ResearcherID
University of Helsinki
ResearcherID
Background: Over 95% of all thyroid malignancies are non-medullary thyroid carcinomas (NMTC). Familial NMTC are more aggressive and mortality is higher as compared with sporadic carcinomas. Known genetic factors do not explain all familial NMTC. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbddcb7c599708d6fc14bd3eb1dd988
http://hdl.handle.net/11585/81020
http://hdl.handle.net/11585/81020
