Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Annie-Kim Gilbert"'
Publikováno v:
Synapse. 68:144-152
Extensive alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1, has demonstrated an array of splice variants in mice, rats and humans. Three classes of splice variants have been identified: full-length seven transmembrane (TM) domain v
Autor:
Martin Coupal, Nektaria Markoglou, Fraser McIntosh, Carole Puma, Jennifer M. A. Laird, Xiao Hong Yu, Martin N. Perkins, Giovanni Martino, Annie-Kim Gilbert
Publikováno v:
Pain. 152:2852-2860
The role of muscarinic receptor subtype-1 (M1) in chronic pain is unclear. In an attempt to gain an understanding of its role, we have tested xanomeline, an M1/M4-preferring agonist, together with nonselective (scopolamine and pirenzepine), and selec
Publikováno v:
Cellular Signalling. 18:479-487
The constitutive commitment of neutrophils to apoptosis is a key process for the control and resolution of inflammation and it can be delayed by various inflammatory mediators including leukotriene B4 (LTB4). The mechanisms by which LTB4 contributes
Publikováno v:
European Journal of Pharmacology. 492:123-130
The present study examined the pharmacology of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin (3,6-diacetyldihydromorphine). Like morphine, dihydromorphine and its acetylated derivatives all were highly selective mu-opioids in receptor bi
Publikováno v:
Journal of Medicinal Chemistry. 46:3094-3101
Novel analogues of the minimal antinociceptive histogranin (HN) fragment Gly(7)-Gln-Gly-Arg(10), in which amino acids in positions 8, 9, and 10 were replaced by lipophilic amino acids and corresponding d-amino acid residues in combination with N- to
Publikováno v:
Biochemical and Biophysical Research Communications. 301:1057-1061
The mouse gene encoding the mu opioid receptor, Oprm, undergoes extensive alternatively splicing, with 14 variants having been identified. However, only one variant of human mu opioid receptor gene (Oprm), MOR-1A, has been described. We now report tw
Autor:
Juan Manuel Villalpando, Carol Hudon, Annie-Kim Gilbert, Sébastien S. Hébert, Sylvie Belleville, John C.S. Breitner, Simon Duchesne, Howard Chertkow, Louis Verret, Pierrette Gaudreau, Serge Gauthier, Naguib Mechawar, Frédéric Calon, Andréa C. LeBlanc, Rebecca Fuhrer, Julien Doyon, Nicole Leclerc, Stéphane Poulin, Christian Bocti, Jean-Paul Soucy, Marie-Jeanne Kergoat
Publikováno v:
Alzheimer's & Dementia. 10
Autor:
Keith B.J. Franklin, Annie-Kim Gilbert
Publikováno v:
Pharmacology Biochemistry and Behavior. 68:783-787
The analgesic properties of the catecholamine uptake inhibitor nomifensine were investigated in the tail immersion, hot plate and formalin tests. Systemic administration of nomifensine produced analgesia only in the formalin test. The analgesia was d
Autor:
Lin Yang, Annie-Kim Gilbert, Simon Lemaire, Irma Lemaire, Natacha Leduc, François B. Jolicoeur, Hoang-Thanh Le
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 309(1)
Histogranin (HN)-like nonpeptides were designed and synthesized using benzimidazole (compound 1) and o -phenylenediamine (compounds 2–7) as scaffolds for the attachment of phenolic hydroxyl and basic guanidino pharmacophoric elements present in HN.
Autor:
Keith B.J. Franklin, Annie-Kim Gilbert
Publikováno v:
European journal of pharmacology. 449(1-2)
There has been controversy as to whether the contribution of descending fibers from the rostral ventromedial medulla to opioid analgesia depends on the nature of the noxious stimulus eliciting pain. In the present study, inactivation of descending fi