Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Annie Yarwood"'
Autor:
Stephanie J.W. Shoop-Worrall, Saskia Lawson-Tovey, Lucy R. Wedderburn, Kimme L. Hyrich, Nophar Geifman, Aline Kimonyo, Alyssia McNeece, Andrew Dick, Andrew Morris, Annie Yarwood, Athimalaipet Ramanan, Bethany R. Jebson, Chris Wallace, Daniela Dastros-Pitei, Damian Tarasek, Elizabeth Ralph, Emil Carlsson, Emily Robinson, Emma Sumner, Fatema Merali, Fatjon Dekaj, Helen Neale, Hussein Al-Mossawi, Jacqui Roberts, Jenna F. Gritzfeld, Joanna Fairlie, John Bowes, John Ioannou, Melissa Kartawinata, Melissa Tordoff, Michael Barnes, Michael W. Beresford, Michael Stadler, Paul Martin, Rami Kallala, Sandra Ng, Samantha Smith, Sarah Clarke, Soumya Raychaudhuri, Stephen Eyre, Sumanta Mukherjee, Teresa Duerr, Thierry Sornasse, Vasiliki Alexiou, Victoria J. Burton, Wei-Yu Lin, Wendy Thomson, Zoe Wanstall
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104946- (2024)
Summary: Background: Methotrexate (MTX) is the gold-standard first-line disease-modifying anti-rheumatic drug for juvenile idiopathic arthritis (JIA), despite only being either effective or tolerated in half of children and young people (CYP). To fac
Externí odkaz:
https://doaj.org/article/c923074c829f4905a534120f1e8c1050
Autor:
Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the fin
Externí odkaz:
https://doaj.org/article/fc874bf79d974ecf8ffc27cc8532e984
Autor:
Paul Martin, Amanda McGovern, Jonathan Massey, Stefan Schoenfelder, Kate Duffus, Annie Yarwood, Anne Barton, Jane Worthington, Peter Fraser, Stephen Eyre, Gisela Orozco
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166923 (2016)
BackgroundThe chromosomal region 6q23 has been found to be associated with multiple sclerosis (MS) predisposition through genome wide association studies (GWAS). There are four independent single nucleotide polymorphisms (SNPs) associated with MS in
Externí odkaz:
https://doaj.org/article/8522a4146c414caba49e01a735871ae1
Autor:
Annie, Yarwood, Stephanie, Shoop-Worrall, Elena, López-Isac, Samantha Louise, Smith, Andrew P, Morris, John David, Bowes, Melissa, Tordoff, Kimme L, Hyrich, Wendy, Thomson
Publikováno v:
Childhood Arthritis Prospective Study (CAPS) Group 2022, ' No evidence that genetic predictors of susceptibility predict changes in core outcomes in JIA ', Rheumatology (Oxford, England) . https://doi.org/10.1093/rheumatology/keab942
Objectives. The clinical progression of JIA is unpredictable. Knowing who will develop severe disease could facilitate rapid intensification of therapies. We use genetic variants conferring susceptibility to JIA to predict disease outcome measures. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888138fb981f6768f49c5ac1c2c3103d
https://pure.manchester.ac.uk/ws/files/222263108/outcome_predictors_paper_2021_revision.docx
https://pure.manchester.ac.uk/ws/files/222263108/outcome_predictors_paper_2021_revision.docx
Autor:
Richard B. Warren, Jenny Hankinson, Patrick M. Gaffney, Magnus Rattray, Oliver Gough, Stephen Eyre, Gisela Orozco, Kate Duffus, Annie Yarwood, Chenfu Shi, Yao Fu, James Ding, Amanda McGovern, Paul Martin, Helen Ray-Jones, Vasanthipriyadarshini Gaddi
Publikováno v:
Shi, C, Ray-Jones, H, Ding, J, Duffus, K, Fu, Y, Gaddi, V P, Gough, O, Hankinson, J, Martin, P, McGovern, A, Yarwood, A, Gaffney, P, Eyre, S, Rattray, M, Warren, R B & Orozco, G 2021, ' Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits ', The Journal of Investigative Dermatology, vol. 141, no. 8, pp. 1975-1984 . https://doi.org/10.1016/j.jid.2021.01.015
Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes. In this study, we use H3K27ac HiChIP, a method for assaying the active chromatin interactome in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d10994e884e95df7c74f8f969732cb8
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
Autor:
Abigail Wood, Andrew P. Morris, John Bowes, Wendy Thomson, Vasanthi Priyadarshini Gaddi, Paul Martin, Marc Sudman, Miranda C. Marion, Gisela Orozco, Stephen Eyre, Chenfu Shi, Annie Yarwood, Sampath Prahalad, Samantha L. Smith, Susan D. Thompson, Elena López-Isac, Carl D. Langefeld
Publikováno v:
Lopez Isac, E, Smith, S, Marion, M C, Wood, A, Sudman, M, Yarwood, A, Shi, C, Gaddi, V, Martin, P, Prahalad, S, Eyre, S, Orozco, G, Morris, A, Langefeld, C D, Thompson, S D, Thomson, W & Bowes, J 2021, ' Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms ', Annals of the rheumatic diseases, vol. 80, pp. 321-328 . https://doi.org/10.1136/annrheumdis-2020-218481
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases
ObjectivesJuvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. Our understanding of the genetic risk factors for this disease is limited due to low disease prevalence and extensive clinical heterogeneity. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6679fdb3e18d30b4c9ebbd88d98ad354
https://www.research.manchester.ac.uk/portal/en/publications/combined-genetic-analysis-of-juvenile-idiopathic-arthritis-clinical-subtypes-identifies-novel-risk-loci-target-genes-and-key-regulatory-mechanisms(25f9789e-5e92-4605-99cf-b029898d24d1).html
https://www.research.manchester.ac.uk/portal/en/publications/combined-genetic-analysis-of-juvenile-idiopathic-arthritis-clinical-subtypes-identifies-novel-risk-loci-target-genes-and-key-regulatory-mechanisms(25f9789e-5e92-4605-99cf-b029898d24d1).html
Autor:
Joyce Davidson, Coziana Ciurtin, Wei-Yu Lin, Kimme L. Hyrich, Jenna F. Gritzfeld, Athimalaipet V Ramanan, Wendy Thomson, Elizabeth Ralph, Sally-Anne Dews, Aline Kimonyo, Fatjon Dekaj, Paul Martin, Emil Carlsson, Zoe Wanstall, Lucy R. Wedderburn, Saskia Lawson-Tovey, Annie Yarwood, Beth Jebson, Toby Kent, Stephanie J W Shoop-Worrall, Sandra Ng, Chris Wallace, Emily Robinson, Joanna Fairlie, Michael R. Barnes, Alice Chieng, Samantha L. Smith, Andrew D. Dick, Teresa Duerr, Damian Tarasek, Andrew D. Morris, Jessica Neisen, Melissa Kartawinata, Fatema Merali, Emma Sumner, Eileen Baildam, Helen Neale, Michael W. Beresford, Helen E. Foster, Soumya Raychaudhuri, Flora McErlane, Gavin Cleary, Gil Reynolds Diogo, Yiannis Ioannou, Nophar Geifman
Publikováno v:
Shoop-Worrall, S, Hyrich, K, CLUSTER Consortium, Wedderburn, L R, Thomson, W & Geifman, N 2020, ' Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile idiopathic arthritis in the UK: a multicentre prospective longitudinal study ', The Lancet Rheumatology, vol. 3, no. 2, pp. E111-E121 . https://doi.org/10.1016/S2665-9913(20)30269-1
The Lancet Rheumatology
The Lancet Rheumatology
Summary Background Juvenile idiopathic arthritis (JIA) is a heterogeneous disease, the signs and symptoms of which can be summarised with use of composite disease activity measures, including the clinical Juvenile Arthritis Disease Activity Score (cJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28b2329d637410519e22c4b9cca6d8f
http://www.scopus.com/inward/record.url?scp=85097886139&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85097886139&partnerID=8YFLogxK
Autor:
Jenny Hankinson, Steve Eyre, Patrick M. Gaffney, Gisela Orozco, Oliver Gough, Amanda McGovern, James Ding, Andrew P. Morris, Kate Duffus, Helen Ray-Jones, Paul Martin, Yao Fu, Vasanthi Priyadarshini Gaddi, Chenfu Shi, Antony Adamson, Richard B. Warren, Christopher J. Taylor, Annie Yarwood
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
BMC Biology
Ray-Jones, H, Duffus, K, Mcgovern, A, Martin, P, Shi, C, Hankinson, J, Gough, O, Yarwood, A, Morris, A, Adamson, A, Taylor, C, Ding, J, Gaddi, V, Fu, Y, Gaffney, P, Orozco, G, Warren, R & Eyre, S 2020, ' Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 ', BMC Biology, vol. 18, no. 1, 47 . https://doi.org/10.1186/s12915-020-00779-3
BMC Biology
Ray-Jones, H, Duffus, K, Mcgovern, A, Martin, P, Shi, C, Hankinson, J, Gough, O, Yarwood, A, Morris, A, Adamson, A, Taylor, C, Ding, J, Gaddi, V, Fu, Y, Gaffney, P, Orozco, G, Warren, R & Eyre, S 2020, ' Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 ', BMC Biology, vol. 18, no. 1, 47 . https://doi.org/10.1186/s12915-020-00779-3
Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d886c3d672fdc1cb7dd0cad1f0fbf777
https://doi.org/10.1186/s12915-020-00779-3
https://doi.org/10.1186/s12915-020-00779-3
Autor:
Tracy A Briggs, Annie Yarwood, Samantha L. Smith, Wendy Thomson, John Bowes, Melissa K Tordoff
Publikováno v:
Rheumatology. 59
Background Juvenile idiopathic arthritis (JIA) is a rheumatic disease, onset before the age of sixteen. JIA is a common complex disease, with contributions from both genetic and environmental risk factors. However, given the young age of onset for JI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed24c646ff3e9b7a32f0cedd08cf547
https://doi.org/10.1093/rheumatology/keaa111.017
https://doi.org/10.1093/rheumatology/keaa111.017
Autor:
John Bowes, Damian Tarasek, Susan D. Thompson, Carl D. Langefeld, Samantha L. Smith, Marc Sudman, Wendy Thomson, Annie Yarwood, Miranda C. Marion
Publikováno v:
Rheumatology. 59
Background Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous group of childhood onset inflammatory joint diseases with strong evidence to support a genetic contribution to susceptibility. JIA is divided into seven clinical subgroups b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170f60595b69098d7085020b69328d52
https://doi.org/10.1093/rheumatology/keaa111.019
https://doi.org/10.1093/rheumatology/keaa111.019