Výsledky vyhledávání - "Annie X. Y. Mo"

Sequences That Flank Subdominant and Cryptic Epitopes Influence the Proteolytic Generation of MHC Class I-Presented Peptides

Autor: Abie Craiu, Steven F. L. van Lelyveld, Annie X. Y. Mo, Kenneth L. Rock

Publikováno v: The Journal of Immunology. 164:4003-4010

The proteasome has been shown to make the proper C-terminal cleavage for the generation of several immunodominant class I-presented peptides whereas aminopeptidases generate their proper N termini. In this study, we show that these two distinct prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74e9ec3cb390cf79e7f14393f017192
https://doi.org/10.4049/jimmunol.164.8.4003

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The Cytosolic Endopeptidase, Thimet Oligopeptidase, Destroys Antigenic Peptides and Limits the Extent of MHC Class I Antigen Presentation

Autor: Wanyong Zeng, Ian A. York, Annie X. Y. Mo, Kristen Lemerise, Kenneth L. Rock, Carmela R. Abraham, Tomo Saric, Yuelei Shen, Alfred L. Goldberg

Publikováno v: Immunity. (3):429-440

Most antigenic peptides presented on MHC class I molecules are generated by proteasomes during protein breakdown. It is unknown whether these peptides are protected from destruction by cytosolic peptidases. In cytosolic extracts, most antigenic pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc91e33250affefd18fe8a77993c2cb

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