Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Annie X. Liu"'
Autor:
Arjun Saha, Annie X. Liu, Samantha J Allen, Teena M Varghese, Michael D. Hack, Taraneh Mirzadegan
Publikováno v:
Journal of chemical information and modeling. 58(10)
Since many projects at pharmaceutical organizations get their start from a high-throughput screening (HTS) campaign, improving the quality of the HTS deck can improve the likelihood of discovering a high-quality lead molecule that can be progressed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3005dae336d7eccd61e7169f0cce2531
https://pubmed.ncbi.nlm.nih.gov/30204440
https://pubmed.ncbi.nlm.nih.gov/30204440
Autor:
Stefan Steinbacher, Annie X. Liu, Paul F. Jackson, Marina I. Nelen, Marcos E. Milla, Krystal Herman, Aaron N. Patrick, Jonathan M. Blevitt, Paul J. Krawczuk, Kevin J. Lumb, Alec D. Lebsack, Taraneh Mirzadegan, Michael D. Hack
Publikováno v:
Journal of medicinal chemistry. 60(8)
A prevalent observation in high-throughput screening and drug discovery programs is the inhibition of protein function by small-molecule compound aggregation. Here, we present the X-ray structural description of aggregation-based inhibition of a prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c2452e043c3c88a3cc89cdec313139
https://pubmed.ncbi.nlm.nih.gov/28300404
https://pubmed.ncbi.nlm.nih.gov/28300404
Autor:
Neill R. Graff-Radford, Jelena Mojsilovic-Petrovic, Fadia Ibrahim, Zamia Diaz, Kelly L. Williams, Garth A. Nicholson, Ashley Chiang, John Q. Trojanowski, Lauren Elman, Nancy M. Bonini, Oliver D. King, Dennis W. Dickson, James Epstein, Rosa Rademakers, Hyung-Jun Kim, Robert G. Kalb, Rachel Oristano, Dana Clay-Falcone, Jennifer A. Solski, Tadashi Nakaya, Leo McCluskey, Ian P. Blair, Divya Hosangadi, Caroline Ingre, Michael P. Hart, Albert C. Ludolph, Zissimos Mourelatos, Robert W. Greene, Annie X. Liu, Virginia M.-Y. Lee, Aaron D. Gitler, Daniel M. Ramos, Julien Couthouis, Renske Erion, Kevin B. Boylan, Niti Jethava, Mariely DeJesus-Hernandez, Peter M. Andersen, James Shorter, Wim Robberecht, Vivianna M. Van Deerlin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease. Mutations in two related RNA-binding proteins, TDP-43 and FUS, that harbor prion-like domains, cause some forms of ALS. There are at least 213 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c131698869d98f8c7094d2b3784d7fb
https://pubmed.ncbi.nlm.nih.gov/36577079
https://pubmed.ncbi.nlm.nih.gov/36577079