Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Annie Wai Yeeng Chai"'
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e39677- (2024)
Oral squamous cell carcinoma (OSCC) is known to be driven by multiple intricated receptor tyrosine kinases (RTKs) including EGFR, PI3K/AKT and MAPK signaling pathways. However, whilst targeting EGFR with cetuximab has been approved for the treatment
Externí odkaz:
https://doaj.org/article/4d3833f21f594f75aed68e2603d4966a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Effective treatment options for head and neck squamous cell carcinoma (HNSCC) are currently lacking. We exploited the drug response and genomic data of the 28 HNSCC cell lines, screened with 4,518 compounds, from the PRISM repurposing datase
Externí odkaz:
https://doaj.org/article/edc4ab846e8145aeb8e9e2bdcef4f467
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Immunotherapy, especially the immune checkpoint inhibitors (ICIs) such as the pembrolizumab and nivolumab have contributed to significant improvements in treatment outcomes and survival of head and neck cancer (HNC) patients. Still, only a subset of
Externí odkaz:
https://doaj.org/article/9d2e7d54699141b896fc79923afb06eb
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Autor:
Annie Wai Yeeng Chai, Pei San Yee, Stacey Price, Shi Mun Yee, Hui Mei Lee, Vivian KH Tiong, Emanuel Gonçalves, Fiona M Behan, Jessica Bateson, James Gilbert, Aik Choon Tan, Ultan McDermott, Mathew J Garnett, Sok Ching Cheong
Publikováno v:
eLife, Vol 9 (2020)
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therap
Externí odkaz:
https://doaj.org/article/3808165fca334dd0b13ce47927c27467
Autor:
Pei San Yee, Annie Wai Yeeng Chai, Shi Mun Yee, Shi Yin Ooi, Yee Hua Tan, Mathew Garnett, Siew Kit Ng, Sok Ching Cheong
Publikováno v:
Cancer Research. 83:1704-1704
Treating oral squamous cell carcinoma (OSCC) remains challenging due to limited knowledge of the critical genes that could affect cell survival in OSCC. We have previously utilized genome-wide CRISPR-Cas9 knockout functional screens to explore the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0156e6c8b4159d0d5ff18378eb6079cf
https://doi.org/10.1158/1538-7445.am2023-1704
https://doi.org/10.1158/1538-7445.am2023-1704
Publikováno v:
Seminars in Cancer Biology. 61:71-83
Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142b648cc36b58ad057fcd8a29c2105d
https://doi.org/10.1016/j.semcancer.2019.09.011
https://doi.org/10.1016/j.semcancer.2019.09.011
Publikováno v:
Frontiers in oncology. 12
Immunotherapy, especially the immune checkpoint inhibitors (ICIs) such as the pembrolizumab and nivolumab have contributed to significant improvements in treatment outcomes and survival of head and neck cancer (HNC) patients. Still, only a subset of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbfad049e290d64b5c738f6c6b3f20b
https://pubmed.ncbi.nlm.nih.gov/35372020
https://pubmed.ncbi.nlm.nih.gov/35372020
Autor:
Annie Wai Yeeng Chai, Carissa Wing Yan Wong, Maria Li Lung, Lisa Chan Lei, Shiu Yeung Lam, Lvwen Ning, Josephine Mun Yee Ko, Sheyne Sta Ana Choi
Publikováno v:
Cancers
Volume 13
Issue 18
Cancers, Vol 13, Iss 4715, p 4715 (2021)
Volume 13
Issue 18
Cancers, Vol 13, Iss 4715, p 4715 (2021)
Simple Summary Two deleterious RAD50 loss-of-function germline mutations were identified from the blood DNA of a cohort of 3289 Henan individuals by next-generation sequencing. These rare loss-of-function RAD50 variants were associated with a substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da3c5dd7b307e3cce115fbed53ed6db
Autor:
James G. R. Gilbert, Emanuel Gonçalves, Aik Choon Tan, Stacey Price, Mathew J. Garnett, Pei San Yee, Vivian Kh Tiong, Hui Mei Lee, Ultan McDermott, Sok Ching Cheong, Jessica Bateson, Shi Mun Yee, Fiona M. Behan, Annie Wai Yeeng Chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf00210826532268592d3bbc870ab5a5
https://doi.org/10.7554/elife.57761.sa2
https://doi.org/10.7554/elife.57761.sa2
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
Autor:
Pei San Yee, Fiona M. Behan, Hui Mei Lee, Sok Ching Cheong, Emanuel Gonçalves, Annie Wai Yeeng Chai, Jessica Bateson, Stacey Price, Shi Mun Yee, James G. R. Gilbert, Ultan McDermott, Vivian Kh Tiong, Mathew J. Garnett, Aik Choon Tan
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c328cdc1f700924a2df1678150099c
https://elifesciences.org/articles/57761
https://elifesciences.org/articles/57761