Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Annie Vogel Ciernia"'
Autor:
Jennifer Kim, Olivia Sullivan, Kristen Lee, Justin Jao, Juan Tamayo, Abdullah Muhammad Madany, Brandon Wong, Paul Ashwood, Annie Vogel Ciernia
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-23 (2024)
Abstract Background Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As the brain’s innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have show
Externí odkaz:
https://doaj.org/article/b449e456ad5c4b109b1347b8cb91d6c6
Autor:
Hadley C. Osman, Rachel Moreno, Destanie Rose, Megan E. Rowland, Annie Vogel Ciernia, Paul Ashwood
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Maternal inflammation during gestation is associated with a later diagnosis of neurodevelopmental disorders including autism spectrum disorder (ASD). However, the specific impact of maternal immune activation (MIA) on placental and fetal bra
Externí odkaz:
https://doaj.org/article/038adb03970240cbaf3a9d6f892ae801
Autor:
Laura Meleady, Morgan Towriss, Jennifer Kim, Vince Bacarac, Vivien Dang, Megan E. Rowland, Annie Vogel Ciernia
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
As the primary innate immune cells of the brain, microglia respond to damage and disease through pro-inflammatory release of cytokines and neuroinflammatory molecules. Histone acetylation is an activating transcriptional mark that regulates inflammat
Externí odkaz:
https://doaj.org/article/8fe789b251584367a744896fbae211dd
Autor:
Heather K. Hughes, Megan E. Rowland, Charity E. Onore, Sally Rogers, Annie Vogel Ciernia, Paul Ashwood
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Autism spectrum disorder (ASD) is a complex developmental disorder characterized by deficits in social interactions, communication, and stereotypical behaviors. Immune dysfunction is a common co-morbidity seen in ASD, with innate immune acti
Externí odkaz:
https://doaj.org/article/bca724e7c76c463890ac53741981a4cc
Autor:
Olivia Sullivan, Annie Vogel Ciernia
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Microglia are brain-resident immune cells that play a critical role in synaptic pruning and circuit fine-tuning during development. In the adult brain, microglia actively survey their local environment and mobilize inflammatory responses to signs of
Externí odkaz:
https://doaj.org/article/e93704c0eb6747a88abd83c99c3f1e48
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8967 (2023)
Microglia, the resident macrophages of the central nervous system, play important roles in maintaining brain homeostasis and facilitating the brain’s innate immune responses. Following immune challenges microglia also retain immune memories, which
Externí odkaz:
https://doaj.org/article/4d1dddaafced41a5b485bffdf05589b9
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Accurate and precise regulation of gene expression is necessary to ensure proper brain development and plasticity across the lifespan. As an ATP-dependent chromatin-remodeling complex, the BAF (Brg1 Associated Factor) complex can alter histone-DNA in
Externí odkaz:
https://doaj.org/article/beb00f89da424c4981d12ba6c37b411c
Autor:
Justin Jao, Annie Vogel Ciernia
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11 (2021)
Gene expression analysis is becoming increasingly utilized in neuro-immunology research, and there is a growing need for non-programming scientists to be able to analyze their own genomic data. MGEnrichment is a web application developed both to diss
Externí odkaz:
https://doaj.org/article/469ebf23cbf74d4daa57ff5d04e36698
Autor:
Benjamin I. Laufer, Hyeyeon Hwang, Annie Vogel Ciernia, Charles E. Mordaunt, Janine M. LaSalle
Publikováno v:
Epigenetics, Vol 14, Iss 7, Pp 672-684 (2019)
Down Syndrome (DS) is the most common genetic cause of intellectual disability, in which an extra copy of human chromosome 21 (HSA21) affects regional DNA methylation profiles across the genome. Although DNA methylation has been previously examined a
Externí odkaz:
https://doaj.org/article/cdf003b16614499d9d81868ebb62aa4f
Autor:
Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates me
Externí odkaz:
https://doaj.org/article/8214879eac4444f79329a0009fdad2ee