Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Annie S. Tam"'
Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 1, Pp 133-140 (2016)
Cancer therapy largely depends on chemotherapeutic agents that generate DNA lesions. However, our understanding of the nature of the resulting lesions as well as the mutational profiles of these chemotherapeutic agents is limited. Among these lesions
Externí odkaz:
https://doaj.org/article/263b02a6ad094fcf866795f9ce091d2a
Autor:
Jennifer L. Fish, Kym M. Boycott, Fjodor Merkuri, Peter C. Stirling, Rachel Aber, Matthew A. Lines, Eric Bareke, Marie-Claude Beauchamp, Anissa Djedid, Loydie A. Jerome-Majewska, Annie S. Tam, Jacek Majewski
Publikováno v:
Hum Mol Genet
EFTUD2 is mutated in patients with mandibulofacial dysostosis with microcephaly (MFDM). We generated a mutant mouse line with conditional mutation in Eftud2 and used Wnt1-Cre2 to delete it in neural crest cells. Homozygous deletion of Eftud2 causes b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fc86628f55fca1c543387b382980e0
https://doi.org/10.1093/hmg/ddab051
https://doi.org/10.1093/hmg/ddab051
Autor:
Annie S. Tam, Peter C. Stirling
Publikováno v:
Current Genetics. 65:905-912
The spliceosome has been implicated in genome maintenance for decades. Recently, a surge in discoveries in cancer has suggested that the oncogenic mechanism of spliceosomal defects may involve defective genome stability. The action of the core splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bea7597baa42a309dea87f7d3c2171
https://doi.org/10.1007/s00294-019-00964-0
https://doi.org/10.1007/s00294-019-00964-0
Autor:
Peter C. Stirling, Karissa L. Milbury, Tianna S. Sihota, Annie S. Tam, Veena Mathew, Anni Zhang
Publikováno v:
Molecular Biology of the Cell
RNA processing mutants have been broadly implicated in genome stability, but mechanistic links are often unclear. Two predominant models have emerged: one involving changes in gene expression that perturb other genome maintenance factors and another
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c224816ba0f2fe53ec7d15ec29e781
https://doi.org/10.1091/mbc.e18-07-0439
https://doi.org/10.1091/mbc.e18-07-0439
Autor:
Aly Karsan, Amit Kumar, Shanks A, Shuhe Tsai, Annie S. Tam, Mathew, Bernard Dg, Peter C. Stirling, Emily Yun-Chia Chang, Docking Tr
Genome instability is a hallmark of cancer that arises through a panoply of mechanisms driven by oncogene and tumour-suppressor gene mutations. Oncogenic mutations in the core splicing factor SF3B1 have been linked to genome instability. Since SF3B1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba7ab17da117a0eecfd98fa3ba11a20
https://doi.org/10.1101/2021.05.26.445839
https://doi.org/10.1101/2021.05.26.445839
Autor:
Peter C. Stirling, Fjodor Merkuri, Kim M Boycott, Matthew A Lines, Jennifer L. Fish, Erik Bareke, Rachel Aber, Marie-Claude Beauchamp, Annie S. Tam, Anissa Djedid, Loydie A. Jerome-Majewska, Jacek Majewski
SummaryEFTUD2, a GTPase and core component of the splicesome, is mutated in patients with mandibulofacial dysostosis with microcephaly (MFDM). We generated a mutant mouse line with conditional mutation inEftud2and usedWnt1-Cre2to delete it in neural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa237e13d58caa8c54260068b71bcf1b
https://doi.org/10.1101/2020.09.22.308205
https://doi.org/10.1101/2020.09.22.308205
Publikováno v:
Journal of cell science. 133(23)
Cdc48 (known as VCP in mammals) is a highly conserved ATPase chaperone that plays an essential role in the assembly and disassembly of protein-DNA complexes and in degradation of misfolded proteins. We find that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79a11540ebeb43d05ab88a7c5c4a1377
https://pubmed.ncbi.nlm.nih.gov/33172985
https://pubmed.ncbi.nlm.nih.gov/33172985
Cdc48/VCP is a highly conserved ATPase chaperone that plays an essential role in the assembly or disassembly of protein-DNA complexes and in degradation of misfolded proteins. We find that Cdc48 accumulates during cellular stress at intranuclear prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a083ddf0836e6944dc378a0cf8b954f1
https://doi.org/10.1101/2020.06.16.152934
https://doi.org/10.1101/2020.06.16.152934
Publikováno v:
Journal of Cell Science.
Cdc48/VCP is a highly conserved ATPase chaperone that plays an essential role in the assembly or disassembly of protein-DNA complexes and in degradation of misfolded proteins. We find that Cdc48 accumulates during cellular stress at intranuclear prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f51491ef7ec8d8beb0cf3b3c478cfc7
https://doi.org/10.1242/jcs.252551
https://doi.org/10.1242/jcs.252551
Autor:
Peter C. Stirling, Emily Yun-Chia Chang, Annie S. Tam, Jean-Yves Masson, Steven J.M. Jones, Maria J. Aristizabal, Romulo Segovia, Richa Chaturvedi, Christelle Keong, Yaoqing Shen, Carolina A. Novoa, Michael S. Kobor, Yan Coulombe
Publikováno v:
The Journal of Cell Biology
Chang et al. link the RECQ-like helicase BLM and its yeast orthologue Sgs1 to preventing DNA damage caused by the accumulation of DNA:RNA hybrid structures called R-loops. This adds to a growing family of helicases implicated in R-loop resolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57274ef3125e28dd2d94569ae9d37ca5
https://doi.org/10.1083/jcb.201703168
https://doi.org/10.1083/jcb.201703168