Výsledky vyhledávání - "Annie S Y Chan"

Akademický článek

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS pa

Externí odkaz: https://doaj.org/article/9ffe8e161f6f47b6ae292571819e0a78

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Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Publikováno v: Gut, 69(12), 2165-2179. BMJ Publishing Group

ObjectiveSporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.DesignWe established pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f088e70976d8619feae560c7711a9e
https://doi.org/10.1136/gutjnl-2019-320019

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Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models

Autor: Yin Tong, Priscilla S W Cheng, Chung Sze Or, Sarah S K Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y K Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S Y Chan, April S Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H N Yan

Publikováno v: Gut. 72(2)

ObjectiveCell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells.DesignWe explored CC and CM dependence in 58 gastric cancer (GC) organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2f0a7f7354ec79b1de78ffc132ab71
https://pubmed.ncbi.nlm.nih.gov/35705367

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RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

Autor: Jeffrey C W Lai, Suet Yi Leung, Helen H.N. Yan, Siu Lun Ho, Janet F. Y. Lee, Alice H Y Man, Wai Yin Tsui, Annie S Y Chan, Siu Tsan Yuen, Bernard C H Lee, Wai K. Leung, Wai Lun Law, Hans Clevers, Sarah S K Yue, Anthony K W Chan

Publikováno v: Gut. BMJ Publishing Group

OBJECTIVE: Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c66b88971dcf1658a9beec807a24e76
https://doi.org/10.1136/gutjnl-2016-311849

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Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

Publikováno v: Nature Genetics. 43:1219-1223

Gastric cancer is a heterogeneous disease with multiple environmental etiologies and alternative pathways of carcinogenesis. Beyond mutations in TP53, alterations in other genes or pathways account for only small subsets of the disease. We performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f6af4c01d6f1ebf11f44f83a84bd15
https://doi.org/10.1038/ng.982

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Abstract 1448: Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation

Autor: Annie S Y Chan, Helen H.N. Yan, Wai Yin Tsui, Siu Lun Ho, Jeffrey C W Lai, Suet Yi Leung, Anthony K W Chan, Siu Tsan Yuen

Publikováno v: Cancer Research. 77:1448-1448

Serrated polyps can arise in a sporadic or familial polyposis setting and predispose to colorectal cancer (CRC). Recently, we have identified RNF43 germline mutation in a family with Serrated Polyposis Syndrome (Yan et al, GUT 2016). The presence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad35268cbec67482319db15132b63e0a
https://doi.org/10.1158/1538-7445.am2017-1448

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Abstract 4378: Gastric cancer organoid culture shows preserved genomic stability in long-term passage

Autor: Annie S Y Chan, Siu Lun Ho, Sarah Siu Kuen Yue, Suet Yi Leung, Bernard C H Lee, Hoi Cheong Siu, Helen H.N. Yan, D Chan, Anthony Kin Wang Chan, Wai Yin Tsui

Publikováno v: Cancer Research. 77:4378-4378

With recent advances in 3D organoid culture techniques, normal epithelial and tumor cells can be directly cultured from clinical specimens in vitro and expanded long-term with a very high success rate. Thus, this constitutes a good platform for vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e66dca6cf53e1bb8a869ee99f8f04207
https://doi.org/10.1158/1538-7445.am2017-4378

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Frequent Microsatellite Instability and Mismatch Repair Gene Mutations in Young Chinese Patients With Colorectal Cancer

Autor: Tsun Leung Chan, Siu Tsan Yuen, Andrew H. Wyllie, Lap Ping Chung, Annie S Y Chan, Suet Yi Leung, Joanna C. Y. Ho, Judy W. C. Ho, Kedo Kwan

Publikováno v: JNCI Journal of the National Cancer Institute. 91:1221-1226

Background: The incidence of colorectal cancer in persons under 46 years of age is substantially higher in Hong Kong than in Scotland and many other countries. Consequently, we examined whether there is a hereditary predisposition for colorectal canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccaf7a79ffc2fcc577d466e545f0813c
https://doi.org/10.1093/jnci/91.14.1221

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