A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions

Autor: Rameswara R. Segireddy, Hugo Belda, Annie S. P. Yang, Kirsten Dundas, Julia Knoeckel, Francis Galaway, Laura Wood, Doris Quinkert, Ellen Knuepfer, Moritz Treeck, Gavin J. Wright, Alexander D. Douglas

Publikováno v: Malaria Journal, Vol 23, Iss 1, Pp 1-19 (2024)

Abstract Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identif

Externí odkaz: https://doaj.org/article/cd30976dbd8d4667bc3b6da3dc678722

Malaria surveillance from both ends: concurrent detection of Plasmodium falciparum in saliva and excreta harvested from Anopheles mosquitoes

Autor: Ana L. Ramírez, Andrew F. van den Hurk, Ian M. Mackay, Annie S. P. Yang, Glen R. Hewitson, Jamie L. McMahon, Justin A. Boddey, Scott A. Ritchie, Sara M. Erickson

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Background Malaria is the most important vector-borne disease in the world. Epidemiological and ecological studies of malaria traditionally utilize detection of Plasmodium sporozoites in whole mosquitoes or salivary glands by microscopy or s

Externí odkaz: https://doaj.org/article/42ec25f58ee14a2aaf0c2144be0b4b04

Comparative assessment of mosquito size and receptiveness toP. falciparuminfection of two rearing procedures forAnophelesmosquitoes

Autor: Wouter Graumans, Kjerstin Lanke, Marga van de Vegte-Bolmer, Rianne Stoter, Giulia Costa, Elena A Levashina, Annie S P Yang, Geert-Jan van Gemert, Teun Bousema

Malaria is transmitted whenAnophelinemosquitoes ingestPlasmodiumparasites during blood-feeding. Artificial feeding assays allow mosquitoes to take up blood from membrane feeders, and are widely used to study malaria transmission. These assays require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dec3b25922e0617a526d5ee48759af0
https://doi.org/10.1101/2023.03.09.531859

Mid-Liver Stage Arrest of Plasmodium falciparum Schizonts in Primary Porcine Hepatocytes

Autor: Saskia C. van der Boor, Geert-Jan van Gemert, Alex E. J. Hanssen, Youri M. van Waardenburg, Matthew B. B. McCall, Teun Bousema, Johannes H. W. de Wilt, Robert W. Sauerwein, Annie S. P. Yang

Publikováno v: Frontiers in Cellular and Infection Microbiology, 12
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

During co-evolution Plasmodium parasites and vertebrates went through a process of selection resulting in defined and preferred parasite-host combinations. As such, Plasmodium falciparum (Pf) sporozoites can infect human hepatocytes while seemingly i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47c8d6f6b3510f15714fe5f192b8cff
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/247975

Novel insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies

Autor: Annie S. P. Yang, Jeron Venhuizen, Joshua M. Obiero, Marynthe Peters, Lisette Meerstein-Kessel, Emma J. Vos, Robert W. Sauerwein, Martijn A. Huynen, Daniel R. Garza, Nicholas I Proellochs, Philip L. Felgner

Publikováno v: PLoS Comput. Biol.
Plos Computational Biology, 17
PLoS Computational Biology
Plos Computational Biology, 17, 4
PLoS Computational Biology, Vol 17, Iss 4, p e1008067 (2021)

Plasmodium species, the causative agent of malaria, have a complex life cycle involving two hosts. The sporozoite life stage is characterized by an extended phase in the mosquito salivary glands followed by free movement and rapid invasion of hepatoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3d9875e475c067146dd0ee3545d1c3
https://lirias.kuleuven.be/handle/123456789/678156