Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Annie P. Chiang"'
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 2, p e1000662 (2010)
Current work in elucidating relationships between diseases has largely been based on pre-existing knowledge of disease genes. Consequently, these studies are limited in their discovery of new and unknown disease relationships. We present the first qu
Externí odkaz:
https://doaj.org/article/eef939051e6d4ceeb0d84efa371ff8a3
Autor:
Annie P. Chiang, Atul J. Butte
Publikováno v:
Clinical Pharmacology & Therapeutics. 85:259-268
The dangers of serious adverse drug reactions (SADRs) are well known to clinicians, pharmacologists, and the lay public. Efforts to elucidate the molecular mechanisms behind SADRs have made significant progress through genetics and gene expression me
Autor:
Jared M. Bischof, Edwin M. Stone, Val C. Sheffield, Todd E. Scheetz, Terry A. Braun, Thomas L. Casavant, Annie P. Chiang
Publikováno v:
Human Mutation. 27:545-552
Pseudogenes are remnants of gene duplication (nonprocessed pseudogenes) and retrotransposition (processed pseudogenes) events. This study describes methods for identifying gene conversion candidates from predicted pseudogenes. Pseudogenes may accumul
Autor:
Charles Searby, Jenifer Secrist, Khalil Elbedour, Amanda L. Ferguson, Val C. Sheffield, Thomas L. Casavant, Rivka Carmi, Edwin M. Stone, Terry A. Braun, Annie P. Chiang, Darryl Y. Nishimura
Publikováno v:
The American Journal of Human Genetics. 75(3):475-484
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, pleiotropic human disorder characterized by obesity, retinopathy, polydactyly, renal and cardiac malformations, learning disabilities, and hypogenitalism. Eight BBS loci have been mapped, an
Autor:
Alexander A. Morgan, Marina Sirota, Julien Sage, Jeewon Kim, Annie P. Chiang, Joel T. Dudley, Atul J. Butte, Alejandro Sweet-Cordero
Publikováno v:
Science Translational Medicine. 3
The application of established drug compounds to novel therapeutic indications, known as drug repositioning, offers several advantages over traditional drug development, including reduced development costs and shorter paths to approval. Recent approa
Autor:
Silke Roedder, Marina Sirota, Pankaj J. Pasricha, Alexander A. Morgan, Reetesh K. Pai, Mohan Shenoy, Annie P. Chiang, Atul J. Butte, Joel T. Dudley, Minnie M. Sarwal
Publikováno v:
Science Translational Medicine. 3
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract for which there are few safe and effective therapeutic options for long-term treatment and disease maintenance. Here, we applied a computational approac
Publikováno v:
Clinical pharmacology and therapeutics. 90(1)
Adverse drug reactions (ADRs) can have severe consequences, and therefore the ability to predict ADRs prior to market introduction of a drug is desirable. Computational approaches applied to preclinical data could be one way to inform drug labeling a
Autor:
Nigam H. Shah, Daniel L. Rubin, Nipun Bhatia, Annie P. Chiang, Mark A. Musen, Clement Jonquet
Publikováno v:
BMC Bioinformatics, Vol 10, Iss Suppl 9, p S14 (2009)
BMC Bioinformatics
BMC Bioinformatics, BioMed Central, 2009, 10 (9:S14), pp.9:S14. ⟨10.1186/1471-2105-10-S9-S14⟩
Scopus-Elsevier
BMC Bioinformatics
BMC Bioinformatics, BioMed Central, 2009, 10 (9:S14), pp.9:S14. ⟨10.1186/1471-2105-10-S9-S14⟩
Scopus-Elsevier
The National Center for Biomedical Ontology (NCBO) is developing a system for automated, ontology-based access to online biomedical resources (Shah NH, et al.: Ontology-driven indexing of public datasets for translational bioinformatics. BMC Bioinfor
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 6, Iss 2, p e1000662 (2010)
PLoS Computational Biology, Vol 6, Iss 2, p e1000662 (2010)
Current work in elucidating relationships between diseases has largely been based on pre-existing knowledge of disease genes. Consequently, these studies are limited in their discovery of new and unknown disease relationships. We present the first qu
Autor:
Annie P. Chiang, Atul J. Butte
Drug repositioning refers to the discovery of alternative uses for drugs--uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing the indication for which a drug of interest could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed0037df73f1600c9ec2268092c7871
https://europepmc.org/articles/PMC2836384/
https://europepmc.org/articles/PMC2836384/