Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Annie M. Jarabek"'
Autor:
Kyeonghee Monica Lee, Richard Corley, Annie M. Jarabek, Nicole Kleinstreuer, Alicia Paini, Andreas O. Stucki, Shannon Bell
Publikováno v:
Toxics, Vol 10, Iss 12, p 760 (2022)
New approach methodologies (NAMs) are emerging chemical safety assessment tools consisting of in vitro and in silico (computational) methodologies intended to reduce, refine, or replace (3R) various in vivo animal testing methods traditionally used f
Externí odkaz:
https://doaj.org/article/3b6b58359df3489993c72a96cf9e262e
Publikováno v:
Environment International, Vol 138, Iss , Pp - (2020)
This paper presents a framework for organizing and accessing mechanistic data on chemical interactions. The framework is designed to support the assessment of risks from combined chemical exposures. The framework covers interactions between chemicals
Externí odkaz:
https://doaj.org/article/8f1e56bd49c4460288b93c510df0e607
Autor:
George M. Woodall, Mark D. Hoover, Ronald Williams, Kristen Benedict, Martin Harper, Jhy-Charm Soo, Annie M. Jarabek, Michael J. Stewart, James S. Brown, Janis E. Hulla, Motria Caudill, Andrea L. Clements, Amanda Kaufman, Alison J. Parker, Martha Keating, David Balshaw, Kevin Garrahan, Laureen Burton, Sheila Batka, Vijay S. Limaye, Pertti J. Hakkinen, Bob Thompson
Publikováno v:
Atmosphere, Vol 8, Iss 10, p 182 (2017)
The US Environmental Protection Agency (EPA) and other federal agencies face a number of challenges in interpreting and reconciling short-duration (seconds to minutes) readings from mobile and handheld air sensors with the longer duration averages (h
Externí odkaz:
https://doaj.org/article/5a986da8c2154cd192af9bb49a4ff0cf
Autor:
Qiang Zhang, Jingbo Pi, Courtney G. Woods, Annie M. Jarabek, Harvey J. Clewell, Melvin E. Andersen
Publikováno v:
Dose-Response, Vol 6 (2008)
Hormetic dose response occurs for many endpoints associated with exposures of biological organisms to environmental stressors. Cell-based U- or inverted U-shaped responses may derive from common processes involved in activation of adaptive responses
Externí odkaz:
https://doaj.org/article/5da87720d3ae47cc9e81c0d565c8befe
Autor:
Shaun D. McCullough, David S Morgan, Hannah J Smith, Annie M. Jarabek, Elizabeth M. Martin, David Diaz-Sanchez, Emma C. Bowers, Lisa A. Dailey, Emily R Aungst
Publikováno v:
Toxicol Sci
Inhaled chemical/material exposures are a ubiquitous part of daily life around the world. There is a need to evaluate potential adverse effects of both single and repeat exposures for thousands of chemicals and an exponentially larger number of expos
Autor:
Andrew D. Kraft, George M. Woodall, John E. Whalan, Susan L. Makris, Barbara S. Glenn, Paul Reinhart, Audrey Galizia, John Stanek, Annie M. Jarabek
Publikováno v:
Toxicology Letters. 312:167-172
The inherent complexity of generating and monitoring a test article in an inhalation chamber can make inhalation toxicity testing challenging. Poor study design, human error, and electrical and mechanical problems can adversely affect an inhalation e
Human exposure to metals in consumer-focused fused filament fabrication (FFF)/ 3D printing processes
Publikováno v:
Sci Total Environ
Fused filament fabrication (FFF) or 3D printing is a growing technology used in industry, cottage industry and for consumer applications. Low-cost 3D printing devices have become increasingly popular among children and teens. Consequently, 3D printer
Publikováno v:
Environmental Science & Technology. 53:11002-11012
Exposure to environmental contaminants can lead to adverse outcomes in both human and nonhuman receptors. The Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) frameworks can mechanistically inform cumulative risk assessment for huma
Autor:
David E. Hines, Annie M. Jarabek
Publikováno v:
Current Opinion in Toxicology. 16:83-92
Modernizing risk assessment methods that underlie risk management decisions developed to protect public and environmental health will require interdisciplinary dialog and communication. Alignment of exposures across traditional data streams such as d
Autor:
Anne E. Thessen, Cynthia J. Grondin, Susanne M. Brander, Mary D. Willis, Tiffany J. Callahan, Lisa Truong, Resham D. Kulkarni, Susan A. Korrick, Melissa A. Haendel, Lyle D. Burgoon, Sarah E. Rothenberg, Brian Westra, Lauren E. Chan, Annie M. Jarabek, Nicole Vasilevsky
Publikováno v:
Environmental Health Perspectives
Background: A critical challenge in genomic medicine is identifying the genetic and environmental risk factors for disease. Currently, the available data links a majority of known coding human genes to phenotypes, but the environmental component of h