Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Annie Borch"'
Autor:
Marco Donia, Marie Christine Wulff Westergaard, Sine Reker Hadrup, Kalijn Bol, Inge Marie Svane, Arianna Draghi, Anders Jespersen, Sofie Kirial Mørk, Christina Westmose Yde, Torben Lorentzen, Mohammad Kadivar, Daniela Kleine-Kohlbrecher, Benedetta Albieri, Joachim Stoltenborg Granhøj, Signe Koggersbøl Skadborg, Annie Borch, Nadia Viborg Petersen, Nikolas Thuesen, Ida Svahn Rasmussen, Lars Vibe Andreasen, Rebecca Bach Dohn, Nis Noergaard, Anders Bundgaard Soerensen, Dennis Christensen, Jens Kringelum
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Neoantigens can serve as targets for T cell-mediated antitumor immunity via personalized neopeptide vaccines. Interim data from our clinical study NCT03715985 showed that the personalized peptide-based neoantigen vaccine EVX-01, formulated
Externí odkaz:
https://doaj.org/article/ba4e7a8820d44fe594ecfd552cb83643
Autor:
Annie Borch, Ibel Carri, Birkir Reynisson, Heli M. Garcia Alvarez, Kamilla K. Munk, Alessandro Montemurro, Nikolaj Pagh Kristensen, Siri A. Tvingsholm, Jeppe Sejerø Holm, Christina Heeke, Keith Henry Moss, Ulla Kring Hansen, Anna-Lisa Schaap-Johansen, Frederik Otzen Bagger, Vinicius Araujo Barbosa de Lima, Kristoffer S. Rohrberg, Samuel A. Funt, Marco Donia, Inge Marie Svane, Ulrik Lassen, Carolina Barra, Morten Nielsen, Sine Reker Hadrup
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMutation-derived neoantigens are critical targets for tumor rejection in cancer immunotherapy, and better tools for neoepitope identification and prediction are needed to improve neoepitope targeting strategies. Computational tools have ena
Externí odkaz:
https://doaj.org/article/0bbbca7628154c30a577b6a43214db8d
Autor:
Annie Borch, Anne-Mette Bjerregaard, Vinicius Araujo Barbosa de Lima, Olga Østrup, Christina Westmose Yde, Aron Charles Eklund, Morten Mau-Sørensen, Carolina Barra, Inge Marie Svane, Finn Cilius Nielsen, Samuel A. Funt, Ulrik Lassen, Sine Reker Hadrup
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Immune checkpoint inhibition for the treatment of cancer has provided a breakthrough in oncology, and several new checkpoint inhibition pathways are currently being investigated regarding their potential to provide additional clinical benefit. Howeve
Externí odkaz:
https://doaj.org/article/0b564ce2af7e487693f9954c485f26ea
Autor:
Jeppe Sejerø Holm, Samuel A. Funt, Annie Borch, Kamilla Kjærgaard Munk, Anne-Mette Bjerregaard, James L. Reading, Colleen Maher, Ashley Regazzi, Phillip Wong, Hikmat Al-Ahmadie, Gopa Iyer, Tripti Tamhane, Amalie Kai Bentzen, Nana Overgaard Herschend, Susan De Wolf, Alexandra Snyder, Taha Merghoub, Jedd D. Wolchok, Morten Nielsen, Jonathan E. Rosenberg, Dean F. Bajorin, Sine Reker Hadrup
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Immune checkpoint blockade therapy is successful in a high proportion of cancer patients, but others remain unresponsive. Authors here show that therapeutic success might be predictable in metastatic bladder cancer by longitudinal analysis of the ear
Externí odkaz:
https://doaj.org/article/1e76437c13374a28980b345248e7b551
Autor:
Sunil Kumar Saini, Andreas Due Ørskov, Anne-Mette Bjerregaard, Ashwin Unnikrishnan, Staffan Holmberg-Thydén, Annie Borch, Kathrine Valentini Jensen, Govardhan Anande, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Marianne Bach Treppendahl, Anne Ortved Gang, Inge Høgh Dufva, Zoltan Szallasi, Nicola Ternette, Anders Gorm Pedersen, Aron Charles Eklund, John Pimanda, Kirsten Grønbæk, Sine Reker Hadrup
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cel
Externí odkaz:
https://doaj.org/article/d34a194f6b844353a08c2553d7fdeaee
Autor:
Nikolaj Pagh Kristensen, Christina Heeke, Siri A. Tvingsholm, Annie Borch, Arianna Draghi, Michael D. Crowther, Ibel Carri, Kamilla K. Munk, Jeppe Sejerø Holm, Anne-Mette Bjerregaard, Amalie Kai Bentzen, Andrea M. Marquard, Zoltan Szallasi, Nicholas McGranahan, Rikke Andersen, Morten Nielsen, Göran B. Jönsson, Marco Donia, Inge Marie Svane, Sine Reker Hadrup
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
BACKGROUND Neoantigen-driven recognition and T cell–mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs). Yet how diversity, frequency, and persistence of expanded neoepitop
Externí odkaz:
https://doaj.org/article/d770acf332f045ffaf6a8379f97a7b0f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for ep
Externí odkaz:
https://doaj.org/article/014c5709734849d88591d7722a5d9995
Autor:
Ulla Kring Hansen, Sofie Ramskov, Anne-Mette Bjerregaard, Annie Borch, Rikke Andersen, Arianna Draghi, Marco Donia, Amalie Kai Bentzen, Andrea Marion Marquard, Zoltan Szallasi, Aron Charles Eklund, Inge Marie Svane, Sine Reker Hadrup
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mutation-derived neoantigens are important targets for T cell-mediated reactivity toward tumors and, due to their unique tumor expression, an attractive target for immunotherapy. Neoepitope-specific T cells have been detected across a number of solid
Externí odkaz:
https://doaj.org/article/0da0b48b1adc4d6d9aabde94720619bf
Autor:
Iben Spanggaard, Inge Marie Svane, Sine Reker Hadrup, Morten Hartvig Hansen, Vinicius Araujo Barbosa de Lima, Annie Borch, Arianna Draghi, Ulrik Lassen, Kristoffer Staal Rohrberg
Publikováno v:
Cytotherapy. 22:204-213
Background Immune checkpoint inhibitors (ICIs) have revolutionized the cancer therapeutic landscape and our perception of interactions between the immune system and tumor cells. Despite remarkable progress, disease relapse and primary resistance are
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Schaap-Johansen, A L, Vujović, M, Borch, A, Hadrup, S R & Marcatili, P 2021, ' T Cell Epitope Prediction and Its Application to Immunotherapy ', Frontiers in Immunology, vol. 12, 712488 . https://doi.org/10.3389/fimmu.2021.712488
Frontiers in Immunology, Vol 12 (2021)
Schaap-Johansen, A L, Vujović, M, Borch, A, Hadrup, S R & Marcatili, P 2021, ' T Cell Epitope Prediction and Its Application to Immunotherapy ', Frontiers in Immunology, vol. 12, 712488 . https://doi.org/10.3389/fimmu.2021.712488
T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for ep