Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame

Autor: Gauthier Roy, Rudy Antoine, Annie Schwartz, Stéphanie Slupek, Alex Rivera-Millot, Marc Boudvillain, Françoise Jacob-Dubuisson

Publikováno v: mBio, Vol 13, Iss 4 (2022)

ABSTRACT Copper is essential to most living beings but also highly toxic and as such is an important player at the host-pathogen interface. Bacteria have thus developed homeostatic mechanisms to tightly control its intracellular concentration. Known

Externí odkaz: https://doaj.org/article/5e3595c3d3d446719f92efc6701d0c8a

Clinical Presentation of Hepatocellular Carcinoma in African Americans vs. Caucasians: A Retrospective Analysis

Autor: Krunal Patel, Hrishikesh Samant, Jonathan Steven Alexander, Runhua Shi, Paul Jordan, Annie Schwartz, Kapil Kohli, James G. Morris

Publikováno v: Pathophysiology, Vol 28, Iss 26, Pp 387-399 (2021)
Pathophysiology
Volume 28
Issue 3
Pages 26-399

Hepatocellular carcinoma (HCC) remains an important form of cancer-related morbidity and mortality in the U.S. and worldwide. Previous U.S.-based studies on survival suggest ethnic disparities in HCC patients, but the complex interplay of multiple fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b650bc66123d337199dffdc20e809a48
https://doi.org/10.3390/pathophysiology28030026

A large insertion domain in the Rho factor from a low G+C, Gram-negative bacterium is critical for RNA binding and transcription termination activity

Autor: Mildred Delaleau, Marc Boudvillain, Isabelle Simon, Annie Schwartz

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, 2021, 433 (15), pp.167060. ⟨10.1016/j.jmb.2021.167060⟩
Journal of Molecular Biology, Elsevier, 2021, 433 (15), pp.167060. ⟨10.1016/j.jmb.2021.167060⟩

International audience; Rho-dependent termination of transcription (RDTT) is a critical regulatory mechanism specific to bacteria. In a subset of species including most Actinobacteria and Bacteroidetes, the Rho factor contains a large, poorly conserv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9a3bfb26647f14ac0f28a49d4ccd12
https://cnrs.hal.science/hal-03248336

Evaluating the Effect of Small RNAs and Associated Chaperones on Rho-Dependent Termination of Transcription In Vitro

Autor: Mildred Delaleau, Cédric Nadiras, Annie Schwartz, Marc Boudvillain

Publikováno v: Methods in Mecular Biology
Methods in Mecular Biology, 1737, humana press, Totowa, NJ-USA, pp.99-118, 2018, Bacterial regulatory RNA (Arluison & Valverde, eds), ⟨10.1007/978-1-4939-7634-8_7⟩
Methods in Molecular Biology ISBN: 9781493976331

International audience; Besides their well-known posttranscriptional effects on mRNA translation and decay, sRNAs and associated RNA chaperones (e.g., Hfq, CsrA) sometimes regulate gene expression at the transcriptional level. In this case, the sRNA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c167664056ef1d21e7b5a40ff38b35
https://hal.archives-ouvertes.fr/hal-01880631

The Sm-like RNA chaperone Hfq mediates transcription antitermination at Rho-dependent terminators

Autor: Makhlouf Rabhi, Véronique Arluison, Bastien Cayrol, Annie Schwartz, Marc Boudvillain, Olivier Espéli, A. Rachid Rahmouni

Publikováno v: The EMBO Journal. 30:2805-2816

In Escherichia coli, the essential motor protein Rho promotes transcription termination in a tightly controlled manner that is not fully understood. Here, we show that the general post-transcriptional regulatory protein Hfq associates with Rho to reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9af24d672fa21731f99edd0cd99c8607
https://doi.org/10.1038/emboj.2011.192