Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Annick Seithel"'
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Akademický článek
Evobrutinib, a covalent Bruton’s tyrosine kinase inhibitor: Mass balance, elimination route, and metabolism in healthy participants
Autor: Holger Scheible, Martin Dyroff, Annick Seithel‐Keuth, Eleanor Harrison‐Moench, Nadra Mammasse, Andreas Port, Angelika Bachmann, Jennifer Dong, Jan Jaap vanLier, William Tracewell, David Mitchell
Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2420-2430 (2021)
Abstract The highly selective, covalent Bruton’s tyrosine kinase inhibitor evobrutinib is under investigation for treatment of patients with multiple sclerosis (MS). Early clinical studies in healthy participants and patients with relapsing MS indi
Externí odkaz: https://doaj.org/article/489421b638da46dbad0cbcea83c71c6e
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2
Phase I trial of ATM inhibitor M3541 in combination with palliative radiotherapy in patients with solid tumors
Autor: Saiama N. Waqar, Clifford Robinson, Anthony J. Olszanski, Alexander Spira, Melissa Hackmaster, Luisa Lucas, Laura Sponton, Hulin Jin, Ursula Hering, Damien Cronier, Marianna Grinberg, Annick Seithel-Keuth, Ivan Diaz-Padilla, Jordan Berlin
Publikováno v: Investigational New Drugs. 40:596-605
SummaryBackground. Ataxia telangiectasia mutated (ATM) kinase orchestrates DNA double strand break (DSB) repair; ATM inhibitors may therefore enhance the therapeutic effect of DSB-inducing treatments such as radiotherapy (RT). M3541 is an orally admi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15eaac333ceab39ef47a904583efb186
https://doi.org/10.1007/s10637-022-01216-8
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3
Cladribine as a Potential Object of Nucleoside Transporter-Based Drug Interactions
Autor: Robert Hermann, Peter Krajcsi, Markus Fluck, Annick Seithel-Keuth, Afrim Bytyqi, Andrew Galazka, Alain Munafo
Publikováno v: Clinical Pharmacokinetics. 61:167-187
Cladribine is a nucleoside analog that is phosphorylated in its target cells (B and T-lymphocytes) to its active triphosphate form (2-chlorodeoxyadenosine triphosphate). Cladribine tablets 10 mg (Mavenclad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6cd2fe6e73e87495f734393ce868c0
https://doi.org/10.1007/s40262-021-01089-9
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4
Evobrutinib, a covalent Bruton’s tyrosine kinase inhibitor: Mass balance, elimination route, and metabolism in healthy participants
Autor: Eleanor Harrison-Moench, Jan J. van Lier, Jennifer Dong, Angelika Bachmann, David Mitchell, Andreas Port, Nadra Mammasse, Annick Seithel-Keuth, Martin Dyroff, William Tracewell, Holger Scheible
Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2420-2430 (2021)
Clinical and Translational Science
The highly selective, covalent Bruton’s tyrosine kinase inhibitor evobrutinib is under investigation for treatment of patients with multiple sclerosis (MS). Early clinical studies in healthy participants and patients with relapsing MS indicated tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918d725112442079a32e919b8e766712
https://doi.org/10.1111/cts.13108
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5
Review of Transporter Substrate, Inhibitor, and Inducer Characteristics of Cladribine
Autor: Andrew Galazka, Peter Krajcsi, Alain Munafo, Markus Fluck, Annick Seithel-Keuth, Robert Hermann, Afrim Bytyqi
Publikováno v: Clinical Pharmacokinetics
Cladribine is a nucleoside analog that is phosphorylated in its target cells (B- and T-lymphocytes) to its active adenosine triphosphate form (2-chlorodeoxyadenosine triphosphate). Cladribine tablets 10 mg (Mavenclad®) administered for up to 10 days
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de91223e03a7f87c1ca37b6d68eeaec5
http://europepmc.org/articles/PMC8613159
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6
Abstract CT272: Pharmacodynamic and immunophenotyping analyses of ATR inhibitor M1774 in a Phase I study in patients with solid tumors (DDRiver Solid Tumors 301)
Autor: Ruth Plummer, Anthony W. Tolcher, Timothy A. Yap, Giuseppe Sessa, Jatinder K. Mukker, Annick Seithel-Keuth, Christine Hicking, Zoltan Szucs, Ioannis Gounaris, Giuseppe Locatelli, Johann S. de Bono
Publikováno v: Cancer Research. 83:CT272-CT272
Background: Ataxia telangiectasia and Rad3-related (ATR) protein kinase plays a critical role in the DNA damage response. M1774, a potent, selective, orally administered ATR inhibitor with antitumor activity in preclinical models, was evaluated in Pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5f4efca87d08aee9056d8cfeb2ef327
https://doi.org/10.1158/1538-7445.am2023-ct272
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Absolute Bioavailability and Effect of Food on the Disposition of Safinamide Immediate Release Tablets in Healthy Adult Subjects
Autor: Annick Seithel-Keuth, Sonja Krösser, Michael Lissy, Andreas Johne, Achim Freisleben, Katrin Kupas
Publikováno v: Clinical Pharmacology in Drug Development. 2:79-89
The objectives of this study were to establish the basic intravenous (IV) single-dose PK of safinamide and its major human metabolites, the absolute bioavailability (BA) and food effect on safinamide tablets. Fourteen healthy adult male and female su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c0744783be484d63cb301737b848678
https://doi.org/10.1002/cpdd.2
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9
The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members
Autor: Annick Seithel, Jörg König, Martin F. Fromm, Hartmut Glaeser
Publikováno v: Expert Opinion on Drug Metabolism & Toxicology. 4:51-64
It is increasingly recognised that uptake transporters of the organic anion-transporting polypeptide (OATP) family play important roles in drug absorption, distribution and excretion. They are expressed in a variety of different tissues, including gu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22677b68de186ed4c6977830b4e3135f
https://doi.org/10.1517/17425255.4.1.51
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10
Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
Autor: Johan Karlsson, Anna Björquist, Anna-Lena Ungell, Annick Seithel, Constanze Hilgendorf
Publikováno v: European Journal of Pharmaceutical Sciences. 28:291-299
The Caco-2 cell monolayer model is widely used as a tool for evaluating human intestinal permeability and interaction with transporters. Therefore, we determined mRNA levels for 15 of the most frequently studied uptake and efflux transporters (MDR1,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1fe0bb4de940ab3f348a2395435eb6
https://doi.org/10.1016/j.ejps.2006.03.003
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