Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Annick Scholliers"'
Autor:
Mari Luz Rosauro, Kris Van Dijck, Gregory Fanning, David McGowan, Sara M. Pérez Benedicto, Bart Stoops, Pierre Jean-Marie Bernard Raboisson, Bertrand Van Schoubroeck, Wendy Mostmans, Annick Scholliers, Tine Thoné, Frederik Pauwels, Mourad Daoubi Khamlichi, Vineet Pande, Tim H. M. Jonckers, Florence Herschke, Helen Horton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3216-3221
In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure-activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high cl
Autor:
Werner Embrechts, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Serge Pieters, Vineet Pande, Geert Pille, Katie Amssoms, Ilham Smyej, Deborah Dhuyvetter, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thone, Dorien De Pooter, Gregory Fanning, Tim H. M. Jonckers, Helen Horton, Pierre Raboisson, David McGowan
Publikováno v:
Journal of Medicinal Chemistry. 61:6236-6246
A novel series of 2,4-diaminoquinazolines was identified as potent dual Toll-like receptor (TLR) 7 and 8 agonists with reduced off-target activity. The stereochemistry of the amino alcohol was found to influence the TLR7/8 selectivity with the ( R) i
Autor:
Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Werner Embrechts, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thoné, Dorien De Pooter, Gregory Fanning, Mari Luz Rosauro, Mourad Daoubi Khamlichi, Ioannis Houpis, Eric Arnoult, Tim H.M. Jonckers, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:711-719
The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the
Autor:
David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Serge Pieters, Annick Scholliers, Tine Thoné, Bertrand Van Schoubroeck, Dorien De Pooter, Wendy Mostmans, Mourad Daoubi Khamlichi, Werner Embrechts, Deborah Dhuyvetter, Ilham Smyej, Eric Arnoult, Samuël Demin, Herman Borghys, Gregory Fanning, Jaromir Vlach, Pierre Raboisson
Publikováno v:
Journal of medicinal chemistry. 59(17)
Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like recept
Autor:
Annick Scholliers, Pascale Dehertogh, Pierre Raboisson, Oliver Lenz, Jan Martin Berke, Els Fransen, Gregory Fanning, Thierry Verbinnen, Jimmy Lindberg, Tse-I Lin, Susan Storm, Herman de Kock, Tania Ivens, Michael Edlund, Leen Vijgen, Lotta Vrang, Katrien Vermeiren, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:1878-1887
TMC435 is a small-molecule inhibitor of the NS3/4A serine protease of hepatitis C virus (HCV) currently in phase 2 development. The in vitro resistance profile of TMC435 was characterized by selection experiments with HCV genotype 1 replicon cells an
Autor:
Pierre Raboisson, Tse-I Lin, Bertil Samuelsson, Frederic Delouvroy, Katrien Vermeiren, Lotta Vrang, Oliver Lenz, Kenneth Simmen, Piet Wigerinck, Michael Edlund, Annick Scholliers, Thierry Verbinnen, Herman de Kock, Åsa Rosenquist, Gregory Fanning
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1377-1385
The hepatitis C virus (HCV) NS3/4A serine protease has been explored as a target for the inhibition of viral replication in preclinical models and in HCV-infected patients. TMC435350 is a highly specific and potent inhibitor of NS3/4A protease select
Autor:
Frederic Delouvroy, Katrien Vermeiren, Dominique Louis Nestor Ghislain Surleraux, Sarvajit Chakravarty, Annick Scholliers, Pierre Raboisson, Tse-I Lin, Thierry Verbinnen, Kenneth Simmen, Oliver Lenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1843-1849
Screening of a focused library of TGF beta kinase inhibitors in the cellular HCV replicon model with luciferase read out yielded a number of low micromolar HCV inhibitors. Medicinal chemistry driven optimization resulted in the discovery of 4-[2-(5-b
Autor:
Marianne Tuefferd, Jama M. Darling, Michael W. Fried, Annick Scholliers, Willem Talloen, Jeroen Aerssens, Gregory Fanning, Susanne Johansson
Summary Background Fibrosis progression in hepatitis C virus (HCV)-infected patients varies greatly between individuals. Chemokines recruit immune cells to the infected liver and may thus play a role in the fibrosis process. Aim To investigate plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6b704f93cf9c850e56b844b272e694
https://europepmc.org/articles/PMC4592471/
https://europepmc.org/articles/PMC4592471/
Autor:
Peter A. Anton, Brendan Larder, Kurt Hertogs, Johan Vingerhoets, Stuart Bloor, Lieve Emma Jan Michiels, Julie Elliott, Annick Scholliers, Michael A. Poles
Publikováno v:
The Journal of Infectious Diseases. 183:143-148
The gastrointestinal mucosa is a major lymphoid tissue reservoir for human immunodeficiency virus (HIV) replication. Genotypic and phenotypic resistance patterns of HIV type 1 (HIV-1) RNA isolated from colonic mucosa were compared with those from the
Autor:
Michael W. Fried, Willem Talloen, John G. McHutchison, Jacques Bollekens, Charles D. Howell, Gregory Fanning, Jama M. Darling, Alexander J. Thompson, Jeroen Aerssens, Mieke De Wit, Nezam H. Afdhal, Michael L. Hudson, Kevin V. Shianna, David Goldstein, Annick Scholliers
Publikováno v:
Hepatology (Baltimore, Md.). 53(1)
Hepatitis C (HCV) is a single stranded RNA virus that usually establishes persistent infection in its host. Of patients exposed to HCV, about 80% will develop chronic viral infection characterized by liver infiltration of HCV-specific and nonspecific