Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

Autor: Frank Michael Lehmann, Nicole von Burg, Robert Ivanek, Claudia Teufel, Edit Horvath, Annick Peter, Gleb Turchinovich, Daniel Staehli, Tobias Eichlisberger, Mercedes Gomez de Agüero, Mairene Coto-Llerena, Michaela Prchal-Murphy, Veronika Sexl, Mohamed Bentires-Alj, Christoph Mueller, Daniela Finke

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the a

Externí odkaz: https://doaj.org/article/214732bb64544cc99449dba97da1e82b

Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

Autor: Mairene Coto-Llerena, Nicole von Burg, Edit Horvath, Daniela Finke, Daniel Staehli, Christoph Mueller, Gleb Turchinovich, Mercedes Gomez de Agüero, Tobias Eichlisberger, Frank M. Lehmann, Mohamed Bentires-Alj, Robert Ivanek, Claudia Teufel, Michaela Prchal-Murphy, Veronika Sexl, Annick Peter

Publikováno v: Lehmann, Frank Michael; von Burg, Nicole; Ivanek, Robert; Teufel, Claudia; Horvath, Edit; Peter, Annick; Turchinovich, Gleb; Staehli, Daniel; Eichlisberger, Tobias; Gomez de Agüero, Mercedes; Coto-Llerena, Mairene; Prchal-Murphy, Michaela; Sexl, Veronika; Bentires-Alj, Mohamed; Mueller, Christoph; Finke, Daniela (2020). Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation. Nature communications, 11(1), p. 1794. Nature Publishing Group 10.1038/s41467-020-15612-2
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Lehmann, F M, von Burg, N, Ivanek, R, Teufel, C, Horvath, E, Peter, A, Turchinovich, G, Staehli, D, Eichlisberger, T, Gomez de Agüero, M, Coto-Llerena, M, Prchal-Murphy, M, Sexl, V, Bentires-Alj, M, Mueller, C & Finke, D 2020, ' Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation ', Nature Communications, vol. 11, no. 1, 1794 . https://doi.org/10.1038/s41467-020-15612-2
Nature Communications

Although group 3 innate lymphoid cells (ILC3s) are efficient inducers of T cell responses in the spleen, they fail to induce CD4+ T cell proliferation in the gut. The signals regulating ILC3-T cell responses remain unknown. Here, we show that transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7e889d18d5d1a71f2f9368544c917f

A Motif within the T Cell Receptor α Chain Constant Region Connecting Peptide Domain Controls Antigen Responsiveness

Autor: Annick Peter, Elisabetta Milia, Ed Palmer, Cosima T. Baldari, Beltran Jaureguiberry, B.Thomas Bäckström

Publikováno v: Immunity. 5:437-447

Mutant alphabeta TCRs were generated by replacing domains of the alpha and beta chain constant regions with homologous domains from TCR delta and gamma chains, respectively. Chimeric TCRs in which the alpha chain contains TCR delta chain sequences wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8ccd4d4c674431c47c661473546580
https://doi.org/10.1016/s1074-7613(00)80500-2

Defective signaling to Fyn by a T cell antigen receptor lacking the alpha -chain connecting peptide motif

Autor: Ed Palmer, Emanuele Orsini, Annick Peter, Cosima T. Baldari, Cristina Ulivieri

Publikováno v: The Journal of biological chemistry. 276(5)

A key role in the communication between the alphabetaTCR and the CD3/zeta complex is played by a specific motif within the connecting peptide domain of the TCR alpha chain (alpha-CPM). T cell hybridomas expressing an alpha-CPM-mutated TCR show a dram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f56a0ea90dad150bbcd8f418698cd41
https://pubmed.ncbi.nlm.nih.gov/11058601

Cytoplasmic tall of the T-cell receptor α-chain is involved in down-regulation, but not signalling

Autor: B. Rubin, Annick Peter, B.Thomas Bäckström, Ed Palmer, Georg Tiefenthaler

Publikováno v: Immunology Letters. 56:2-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abb10df558e2ea1c1215e0fb3eb20b41
https://doi.org/10.1016/s0165-2478(97)85009-2