Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types.

Autor: Audrey Sermeus, Marie Genin, Amélie Maincent, Maude Fransolet, Annick Notte, Lionel Leclere, Hélène Riquier, Thierry Arnould, Carine Michiels

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e47519 (2012)

Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However, the exact mechanisms underlying this process are not well understood. Moreover, according to the cell lines, hypoxia differently influences cell death. The st

Externí odkaz: https://doaj.org/article/a55db14b4d514e98baf657dfa7ae1756

Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis

Autor: Thierry Arnould, Marie Genin, Annick Notte, Céline Tellier, Kassandra Watillon, Carine Michiels, Maude Fransolet, Antoine Fattaccioli, Magali Rebucci, Edith Roegiers

Publikováno v: Notte, A, Rebucci, M, Fransolet, M, Roegiers, E, Genin, M, Tellier, C, Watillon, K, Fattaccioli, A, Arnould, T & Michiels, C 2015, ' Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia. ATF4 activation regulates autophagy and inhibits apoptosis ', The international journal of Biochemistry & Cell biology, vol. 62, pp. 1-14 . https://doi.org/10.1016/j.biocel.2015.02.010

Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2c952e674ba54ef9175545bc4a0f02
https://doi.org/10.1016/j.biocel.2015.02.010

Local mitochondrial-endolysosomal microfusion cleaves voltage- dependent anion channel 1 to promote survival in hypoxia

Autor: Véronique Maguer-Satta, Matthieu Rouleau, Carine Michiels, Marius Ilie, Annick Notte, Sandra Lacas-Gervais, Sebastian Hiller, Joffrey Pelletier, Karine Ilc, Alexander Schmidt, Jacques Pouysségur, Bénédicte Manoury, Thibault Voeltzel, M. Christiane Brahimi-Horn, Paul Hofman, Ricardo Adaixo, Nathalie M. Mazure, Marc Dieu

Publikováno v: Brahimi-Horn, M C, Lacas-Gervais, S, Adaixo, R, Ilc, K, Rouleau, M, Notte, A, Dieu, M, Michiels, C, Voeltzel, T, Maguer-Satta, V, Pelletier, J, Ilie, M, Hofman, P, Manoury, B, Schmidt, A, Hiller, S, Pouysségur, J & Mazure, N M 2015, ' Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia ', Molecular Cell Biology, vol. 35, no. 9, pp. 1491-1505 . https://doi.org/10.1128/MCB.01402-14
Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2015, 35 (9), pp.1491-1505. ⟨10.1128/MCB.01402-14⟩

International audience; The oxygen-limiting (hypoxic) microenvironment of tumors induces metabolic reprogramming and cell survival, but the underlying mechanisms involving mitochondria remain poorly understood. We previously demonstrated that hypoxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb5d7496c018c65c93cd0786edec849
https://pure.unamur.be/ws/files/12627107/2015_8_Brahimi_Horn_C._et_al._Mol._Cell._.pdf

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation

Autor: Noelle Ninane, Annick Notte, Carine Michiels, Thierry Arnould

Publikováno v: Notte, A, Ninane, N, Arnould, T & Michiels, C 2013, ' Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells : Role of autophagy and JNK activation ', Cell Death and Disease, vol. 4, no. 5, pp. e638 . https://doi.org/10.1038/cddis.2013.167
Cell Death & Disease

Cancer cell resistance against chemotherapy is still a heavy burden to improve anticancer treatments. Autophagy activation and the development of hypoxic regions within the tumors are known to promote cancer cell resistance. Therefore, we sought to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf2018a052c09a7584662b5fe9f30ea
https://doi.org/10.1038/cddis.2013.167