Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Annick Lesne"'
Autor:
Kim Philipp Jablonski, Leopold Carron, Julien Mozziconacci, Thierry Forné, Marc-Thorsten Hütt, Annick Lesne
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-15 (2022)
Abstract Background Genome-wide association studies have identified statistical associations between various diseases, including cancers, and a large number of single-nucleotide polymorphisms (SNPs). However, they provide no direct explanation of the
Externí odkaz:
https://doaj.org/article/971c30040d5841b98ac163c4f768dd70
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract In the transcriptional regulatory network (TRN) of a bacterium, the nodes are genes and a directed edge represents the action of a transcription factor (TF), encoded by the source gene, on the target gene. It is a condensed representation of
Externí odkaz:
https://doaj.org/article/7cf0076053024644bf7f04590f5d1e2e
Autor:
Chaima Azouzi, Mariam Jaafar, Christophe Dez, Raghida Abou Merhi, Annick Lesne, Anthony K. Henras, Olivier Gadal
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35S/47S in yeast/human) is achieved by up to hundreds of RNA polymerase I (Pol I) enzymes simultaneously transcribing a sing
Externí odkaz:
https://doaj.org/article/4c2845597b2c441e9187d6213c14f07d
Autor:
Sébastien Calvet, Séphora Sallis, Nehmé Saksouk, Cosette Rebouissou, Catherine Teyssier, Annick Lesne, Florence Cammas, Thierry Forné
Publikováno v:
Cells, Vol 11, Iss 15, p 2392 (2022)
About half of the mammalian genome is constituted of repeated elements, among which endogenous retroviruses (ERVs) are known to influence gene expression and cancer development. The HP1 (Heterochromatin Protein 1) proteins are known to be essential f
Externí odkaz:
https://doaj.org/article/20bc96c941dd4f52aee07a8ac7ba44be
Autor:
Katjana Tantale, Florian Mueller, Alja Kozulic-Pirher, Annick Lesne, Jean-Marc Victor, Marie-Cécile Robert, Serena Capozi, Racha Chouaib, Volker Bäcker, Julio Mateos-Langerak, Xavier Darzacq, Christophe Zimmer, Eugenia Basyuk, Edouard Bertrand
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
HIV-1 viral gene expression stochastically switches between active and inactive states. Here, using improved single molecule RNA microscopy, the authors show that HIV-1 RNA stochastic transcription is achieved by groups of closely spaced polymerases,
Externí odkaz:
https://doaj.org/article/dbe244ad77fd496b96bf165adab3bfd8
Autor:
Jean-Marc Victor, Gaëlle Debret, Annick Lesne, Leigh Pascoe, Pascal Carrivain, Gilles Wainrib, Jean-Pierre Hugot
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156138 (2016)
Numerous genetic and environmental risk factors play a role in human complex genetic disorders (CGD). However, their complex interplay remains to be modelled and explained in terms of disease mechanisms.Crohn's Disease (CD) was modeled as a modular n
Externí odkaz:
https://doaj.org/article/cfd64172d76e4103bdbd2ba784c1874b
Autor:
Amandine Cartier-Michaud, Michel Malo, Cécile Charrière-Bertrand, Gilles Gadea, Christelle Anguille, Ajitha Supiramaniam, Annick Lesne, Franck Delaplace, Guillaume Hutzler, Pierre Roux, Daniel A Lawrence, Georgia Barlovatz-Meimon
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32204 (2012)
The microenvironment of a tumor can influence both the morphology and the behavior of cancer cells which, in turn, can rapidly adapt to environmental changes. Increasing evidence points to the involvement of amoeboid cell migration and thus of cell b
Externí odkaz:
https://doaj.org/article/9d8ee28c46704e0b9af56205aac5afce
Autor:
Marc Hütt, Annick Lesne
Publikováno v:
Frontiers in Neuroinformatics, Vol 3 (2009)
In a recent publication [Müller-Linow et al. (2008) PLoS Computational Biology 4, 1000190] two types of correlations between network topology and dynamics have been observed: waves propagating from central nodes and module-based synchronization. Rem
Externí odkaz:
https://doaj.org/article/16dfb9c7b0a34eddb8d71c5cf2f4a375
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 11, p e1000229 (2008)
Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficu
Externí odkaz:
https://doaj.org/article/f6609c2a1d1f4a59be12b5597be7567e
Autor:
Annick Lesne
Publikováno v:
Cybergeo (2005)
Externí odkaz:
https://doaj.org/article/b19b5da2f1ce45bf8386666072b88155