Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

Autor: Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover

Publikováno v: mBio, Vol 13, Iss 2 (2022)

ABSTRACT In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system. DNA double-strand breaks

Externí odkaz: https://doaj.org/article/88a129a68c75409facefdcd72c7ab6e7

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice.

Autor: Alix Thivolle, Ann-Kathrin Mehnert, Eliane Tihon, Emilia McLaughlin, Annick Dujeancourt-Henry, Lucy Glover

Publikováno v: PLoS Pathogens, Vol 17, Iss 11, p e1010038 (2021)

Antigenic variation is an immune evasion strategy used by Trypanosoma brucei that results in the periodic exchange of the surface protein coat. This process is facilitated by the movement of variant surface glycoprotein genes in or out of a specializ

Externí odkaz: https://doaj.org/article/31e13eb5031649dba360298ff464beb3

Single locus phosphoproteomics reveals phosphorylation of RPA-1 is required for generation of single-strand DNA following a break at a subtelomeric locus

Autor: Emilia McLaughlin, Annick Dujeancourt-Henry, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Michael D Urbaniak, Lucy Glover

Damage to the genetic material of the cell poses a universal threat to all forms of life. Central to the DNA damage response (DDR) is a phosphorylation signalling cascade that leads to the co-ordination of the cellular response to a DNA break. Identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777c47f9b2ef2ccd7b7bb9dfbaef210d
https://doi.org/10.1101/2022.06.15.496243

The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Autor: Marco Prorocic, Richard McCulloch, Sebastian Hutchinson, Lucy Glover, Annick Dujeancourt-Henry, Ann-Kathrin Mehnert

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, ⟨10.1093/nar/gkaa1265⟩
Nucleic Acids Research, 2021, ⟨10.1093/nar/gkaa1265⟩

Homologous recombination dominates as the major form of DNA repair in Trypanosoma brucei, and is especially important for recombination of the subtelomeric variant surface glycoprotein during antigenic variation. RAD50, a component of the MRN complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abee9c1f6f43692cbf874b5ed3da83ba
https://hal-pasteur.archives-ouvertes.fr/pasteur-03112362

Bacterial transformation: ComFA is a DNA-dependent ATPase that forms complexes with ComFC and DprA

Autor: Katarzyna A. Gromek, Hannah R. Foster, Amy Diallo, Petya V. Krasteva, Tanya G. Falbel, Rémi Fronzes, Annick Dujeancourt, Thomas Noe Perry, Francesca Gubellini, Briana M. Burton

Publikováno v: Molecular Microbiology. 105:741-754

Pneumococcal natural transformation contributes to genomic plasticity, antibiotic resistance development and vaccine escape. Streptococcus pneumoniae, like many other naturally transformable species, has evolved sophisticated protein machinery for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc2b2796b6b11a84dca840698c0eea97
https://doi.org/10.1111/mmi.13732