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Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

Autor: Cheng, T.H.T., Thompson, D., Painter, J., O'Mara, T., Gorman, M., Martin, L., Palles, C., Jones, A., Buchanan, D.D., Win, A.K., Hopper, J., Jenkins, M., Lindor, N.M., Newcomb, P.A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Giles, G.G., Pharoah, P., Peto, J., Cox, A., Swerdlow, A., Couch, F., Cunningham, J.M., Goode, E.L., Winham, S.J., Lambrechts, D., Fasching, P., Burwinkel, B., Brenner, H., Brauch, H., Chang-Claude, J., Salvesen, H.B., Kristensen, V., Darabi, H., Li, J., Liu, T., Lindblom, A., Hall, P., Echeverry de Polanco, M., Sans, M., Carracedo, A., Castellvi-Bel, S., Rojas-Martinez, A., Jr, A.S., Teixeira, M.R., Dunning, A.M., Dennis, J., Otton, G., Proietto, T., Holliday, E., Attia, J., Ashton, K., Scott, R.J., McEvoy, M., Dowdy, S.C., Fridley, B.L., Werner, H.M.J., Trovik, J., Njolstad, T.S., Tham, E., Mints, M., Runnebaum, I., Hillemanns, P., Doerk, T., Amant, F., Schrauwen, S., Hein, A., Beckmann, M.W., Ekici, A., Czene, K., Meindl, A., Bolla, M.K., Michailidou, K., Tyrer, J.P., Wang, Q., Ahmed, S., Healey, C.S., Shah, M., Annibali, D., Depreeuw, J., Al-Tassan, N.A., Harris, R., Meyer, B.F., Whiffin, N., Hosking, F.J., Kinnersley, B., Farrington, S.M., Timofeeva, M., Tenesa, A., Campbell, H., Haile, R.W., Hodgson, S., Carvajal-Carmona, L., Cheadle, J.P., Easton, D., Dunlop, M., Houlston, R., Spurdle, A., Tomlinson, I.

Publikováno v: Scientific reports, 5. Nature Publishing Group
Scientific Reports
Cheng, T H, Thompson, D, Painter, J, O'Mara, T, Gorman, M, Martin, L, Palles, C, Jones, A, Buchanan, D D, Ko Win, A, Hopper, J, Jenkins, M, Lindor, N M, Newcomb, P A, Gallinger, S, Conti, D, Schumacher, F, Casey, G, Giles, G G, Pharoah, P, Peto, J, Cox, A, Swerdlow, A, Couch, F, Cunningham, J M, Goode, E L, Winham, S J, Lambrechts, D, Fasching, P, Burwinkel, B, Brenner, H, Brauch, H, Chang-Claude, J, Salvesen, H B, Kristensen, V, Darabi, H, Li, J, Liu, T, Lindblom, A, Hall, P, de Polanco, M E, Sans, M, Carracedo, A, Castellvi-Bel, S, Rojas-Martinez, A, Aguiar Jnr, S, Teixeira, M R, Dunning, A M, Dennis, J, Otton, G, Proietto, T, Holliday, E, Attia, J, Ashton, K, Scott, R J, McEvoy, M, Dowdy, S C, Fridley, B L, Werner, H M, Trovik, J, Njolstad, T S, Tham, E, Mints, M, Runnebaum, I, Hillemanns, P, Dörk, T, Amant, F, Schrauwen, S, Hein, A, Beckmann, M W, Ekici, A, Czene, K, Meindl, A, Bolla, M K, Michailidou, K, Tyrer, J P, Wang, Q, Ahmed, S, Healey, C S, Shah, M, Annibali, D, Depreeuw, J, Al-Tassan, N A, Harris, R, Meyer, B F, Whiffin, N, Hosking, F J, Kinnersley, B, Farrington, S M, Timofeeva, M, Tenesa, A, Campbell, H, Haile, R W, Hodgson, S, Carvajal-Carmona, L, Cheadle, J P, Easton, D, Dunlop, M, Houlston, R, Spurdle, A & Tomlinson, I 2015, ' Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 ', Scientific Reports, vol. 5, 17369 . https://doi.org/10.1038/srep17369

High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b75206639aba75ebc46825f9288911c
https://pure.amc.nl/en/publications/metaanalysis-of-genomewide-association-studies-identifies-common-susceptibility-polymorphisms-for-colorectal-and-endometrial-cancer-near-sh2b3-and-tshz1(6d4040ab-1937-4431-9398-05908d4da84c).html

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