Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Anni I, Nieminen"'
Autor:
Juan C. Landoni, Semin Erkul, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I. Nieminen, Sara A. Wickström, James Stewart, Anu Suomalainen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract High mitochondrial DNA (mtDNA) amount has been reported to be beneficial for resistance and recovery of metabolic stress, while increased mtDNA synthesis activity can drive aging signs. The intriguing contrast of these two mtDNA boosting out
Externí odkaz:
https://doaj.org/article/abaa7a8f0e33491a807e68fa7bc5e122
Autor:
Sebastian Heinzel, Jenna Jureczek, Veera Kainulainen, Anni I. Nieminen, Ulrike Suenkel, Anna-Katharina von Thaler, Christoph Kaleta, Gerhard W. Eschweiler, Kathrin Brockmann, Velma T. E. Aho, Petri Auvinen, Walter Maetzler, Daniela Berg, Filip Scheperjans
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Fecal calprotectin is an established marker of gut inflammation in inflammatory bowel disease (IBD). Elevated levels of fecal calprotectin as well as gut microbial dysbiosis have also been observed in other clinical conditions. However, syst
Externí odkaz:
https://doaj.org/article/a46199f195e744deaee36af9c329bc9e
Autor:
Lei Xing, Vasiliki Gkini, Anni I. Nieminen, Hui-Chao Zhou, Matilde Aquilino, Ronald Naumann, Katrin Reppe, Kohichi Tanaka, Peter Carmeliet, Oskari Heikinheimo, Svante Pääbo, Wieland B. Huttner, Takashi Namba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B. During human neocortex development, ARHGAP11B increases the abundance
Externí odkaz:
https://doaj.org/article/7f5a9fcd3d7146608de6b3e645883f2f
Autor:
Sandra M. Holmberg, Rachel H. Feeney, Vishnu Prasoodanan P.K., Fabiola Puértolas-Balint, Dhirendra K. Singh, Supapit Wongkuna, Lotte Zandbergen, Hans Hauner, Beate Brandl, Anni I. Nieminen, Thomas Skurk, Bjoern O. Schroeder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this micr
Externí odkaz:
https://doaj.org/article/35e639f82dc244a7b99914162b0bef98
Autor:
Heidi Harjunpää, Riku Somermäki, Guillem Saldo Rubio, Manlio Fusciello, Sara Feola, Imrul Faisal, Anni I Nieminen, Liang Wang, Marc Llort Asens, Hongxia Zhao, Ove Eriksson, Vincenzo Cerullo, Susanna C Fagerholm
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Dendritic cells (DCs) are the main antigen presenting cells of the immune system and are essential for anti-tumor responses. DC-based immunotherapies are used in cancer treatment, but their functionality is not optimized and their clinical efficacy i
Externí odkaz:
https://doaj.org/article/9f28aacc6a994772a3261704a4e1c8a3
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Fibromyalgia patients vary in clinical phenotype and treatment can be challenging. The pathophysiology of fibromyalgia is incompletely understood but appears to involve metabolic changes at rest or in response to stress. We enrolled 54 fibro
Externí odkaz:
https://doaj.org/article/0b7ccc93e9d34b70bab4dc336d4119a2
Autor:
Nsrein Ali, Syeda Tayyiba Rahat, Mira Mäkelä, Maryam Nasserinejad, Tommi Jaako, Matti Kinnunen, Jyrki Schroderus, Mikko Tulppo, Anni I. Nieminen, Seppo Vainio
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Metabolite-based sensors are attractive and highly valued for monitoring physiological parameters during rest and/or during physical activities. Owing to their molecular composition consisting of nucleic acids, proteins, and metabolites,
Externí odkaz:
https://doaj.org/article/537ecfa9155e40e0beefb9624617310c
Autor:
Karoliina Kurkinen, Olli Kärkkäinen, Soili M. Lehto, Ilona Luoma, Siiri-Liisi Kraav, Petri Kivimäki, Anni I. Nieminen, Katriina Sarnola, Sebastian Therman, Tommi Tolmunen
Publikováno v:
European Journal of Psychotraumatology, Vol 14, Iss 1 (2023)
Background: Sexual and physical abuse have been associated with long-term systemic alterations such as low-grade inflammation and changes in brain morphology that may be reflected in the metabolome. However, data on the metabolic consequences of sexu
Externí odkaz:
https://doaj.org/article/fd7b9696bc204f07bc5e1b2f9220f25f
Autor:
Nirajan Neupane, Jayasimman Rajendran, Jouni Kvist, Sandra Harjuhaahto, Bowen Hu, Veijo Kinnunen, Yang Yang, Anni I. Nieminen, Henna Tyynismaa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Muscular pathologies, including muscular dystrophy, are caused by a number of cellular and metabolic perturbations; here, consequences of GRPEL1-null disrupted mitochondrial matrix protein import on muscle atrophy, metabolism, and stress responses ar
Externí odkaz:
https://doaj.org/article/121bc40521c0499bbf71f67b33e680f9
Autor:
Linda van den Berg, Krista Kokki, Sylvia J. Wowro, Konstantin M. Petricek, Onur Deniz, Catrin A. Stegmann, Marius Robciuc, Mari Teesalu, Richard G. Melvin, Anni I. Nieminen, Michael Schupp, Ville Hietakangas
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112739- (2023)
Summary: The ability to feed on a sugar-containing diet depends on a gene regulatory network controlled by the intracellular sugar sensor Mondo/ChREBP-Mlx, which remains insufficiently characterized. Here, we present a genome-wide temporal clustering
Externí odkaz:
https://doaj.org/article/65971c572d3b492db9e0387223bacef0