Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Annette Thiel"'
Autor:
Annette Thiel, Rebecca Kesselring, Ralph Pries, Alexander Puzik, Nadine Wittkopf, Barbara Wollenberg
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15997 (2011)
Human Plasmacytoid Dendritic Cells (PDCs) infiltrating solid tumor tissues and draining lymph nodes of Head and Neck Squamous Cell Carcinoma (HNSCC) show an impaired immune response. In addition to an attenuated secretion of IFN-α little is known ab
Externí odkaz:
https://doaj.org/article/02746d1e7e70423aa0ccc253900a6179
Autor:
Wolfgang Mueller-Klieser, Evelyn Ullrich, E. K. Geissler, Andreas Villunger, Almut Brand, Sigrid Karrer, Kathrin Renner, André Steven, Peter J. Oefner, Stefan Walenta, Elisabeth Kohl, Annette Thiel, Christian U. Blank, Gudrun E. Koehl, Jacques Pouysségur, Sebastian Haferkamp, Maximilian Schmid, Marina Kreutz, Carina Matos, Stefan Fichtner-Feigl, Katja Dettmer, Petra Hoffmann, Ulrike Schleicher, Sebastian Klobuch, Barbara Seliger, Katrin Singer, Michael Kastenberger, Christian Bogdan, Matthias Mack, Mark Berneburg, K. Peter, Stephan Schreml, Uwe Ritter, Wolfgang Herr, Marlene Kolitzus, Andreas Mackensen, Christina Bruss, Rebecca Kesselring, Gabriele Schoenhammer
Publikováno v:
Cell Metabolism. 24:657-671
Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mi
Autor:
Stefan M. Brunner, Ralph Pries, Rebecca Kesselring, Annette Thiel, Barbara Wollenberg, Philipp Seidel, Stefan Fichtner-Feigl, Karl-Ludwig Bruchhage
Publikováno v:
European Journal of Cancer. 50:2152-2161
Background Membrane-bound complement restriction proteins (mCRPs) CD46, CD55 and CD59 enable tumour cells to evade complement dependent cytotoxicity and antibody-dependent killing mechanisms. But less is known about the role of these mCRPs in head an
Autor:
Werner A. Scherbaum, Matthias Schott, Margret Ehlers, Klaus L. Meyer, Claudia Papewalis, Evelyn Ullrich, Wiebke Stenzel, Benedikt Jacobs, René Deenen, Laurence Zitvogel, Holger S. Willenberg, Annette Thiel, Sven Schinner
Publikováno v:
Endocrinology. 153:4367-4379
Natural killer (NK) cells belong to the innate immune system. Besides their role in antitumor immunity, NK cells also regulate the activity of other cells of the immune system, including dendritic cells, macrophages, and T cells, and may, therefore,
Autor:
Margret Ehlers, Werner A. Scherbaum, Annette Thiel, Hubertus Hautzel, Claudia Papewalis, Matthias Schott, Holger S. Willenberg, Sven Schinner, Dominika Porwol, Christian Bernecker
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:1347-1354
Hashimoto's thyroiditis (HT) is a common autoimmune disease leading to thyroid destruction due to lymphocytic infiltration. Only rare data are available regarding the recognition of specific cellular antigens, e.g. of thyroperoxidase (TPO) and thyrog
Publikováno v:
Cellular Immunology. 269:74-77
Background Despite lots of research efforts, the pathology of head and neck cancer remains elusive. Accumulating evidence suggests that the innate and adaptive immunity plays an important role in HNSCC (Head and Neck Squamous Cell Carcinoma) developm
Autor:
Annette Thiel, Achim Jörres, Katharina Dunkel, Janusz Witowski, Gerhard M. Gahl, Thorsten O. Bender, Ralf Dechend, Jan M. Langrehr, Ulrich Frei, Nina Fouquet
Publikováno v:
The American Journal of Pathology. 158:1441-1450
Leukocyte accumulation during peritonitis is believed to be controlled by chemotactic factors released by resident peritoneal macrophages or mesothelial cells. Recent data indicate, however, that in many tissues fibroblasts play a key role in mediati
Publikováno v:
Innate immunity. 19(1)
Neonates demonstrate functional immaturity and dysregulation of immune responses leading to systemic inflammation and enhanced apoptosis of immune cells. Thalidomide has already been proven to differentially regulate immune responses and support anti
Autor:
Nadine Wittkopf, Barbara Wollenberg, Ralph Pries, Annette Thiel, Alexander Puzik, Rebecca Kesselring
Publikováno v:
Oncology Reports.
Human plasmacytoid dendritic cells (PDCs) are present in solid tumor tissue and metastatic cervical lymph nodes (CLN) in head and neck squamous cell carcinoma (HNSCC). We recently showed that classical PDC functions are heavily disturbed in the tumor
Publikováno v:
Anticancer research. 29(8)
Plasmacytoid dendritic cells (PDCs) infiltrating solid tumor tissues and draining lymph nodes of head and neck squamous cell carcinoma (HNSCC) show an impaired immune response. Immunosuppressive cytokines secreted by HNSCC have been recognized to acc