Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Annette Sindram"'
Autor:
Thomas Burmeister, Nicola Gökbuget, Stefan Schwartz, Lars Fischer, Daniela Hubert, Annette Sindram, Dieter Hoelzer, Eckhard Thiel
Publikováno v:
Haematologica, Vol 95, Iss 2 (2010)
Background The t(9;22) and t(4;11) chromosomal translocations, which generate the BCR-ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia in adults. However, the prognostic impact of other rarer fusion genes is les
Externí odkaz:
https://doaj.org/article/fb2404e92ad24a3a8ec7a7601b21e1e0
Publikováno v:
Leukemia & Lymphoma. 54:145-152
Mutation of the FMS-like tyrosine kinase-3 (FLT3) gene occurs with a frequency of 20-25% in acute myeloid leukemia (AML). Different studies have reported conflicting results, stating the importance of the length, position and number of internal tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc91fe5692e883da2b973dcfd53e2f35
https://doi.org/10.3109/10428194.2012.704999
https://doi.org/10.3109/10428194.2012.704999
Autor:
Gundula Thiel, Olga Blau, Igor Wolfgang Blau, Thomas Burmeister, Seval Türkmen, Annette Sindram, Stefan Mundlos, Eckhard Thiel, Claudia D. Baldus, Florian Nolte, Wolf-Karsten Hofmann, Mara Molkentin, Ulrich Keilholz, Ouidad Benlasfer, Elke Schümann
Publikováno v:
Blood. 118:5583-5592
Mesenchymal stromal cells (MSCs) are an essential cell type of the hematopoietic microenvironment. Concerns have been raised about the possibility that MSCs undergo malignant transformation. Several studies, including one from our own group, have sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baec786f58fe96c62df3179f162cbdb
https://doi.org/10.1182/blood-2011-03-343467
https://doi.org/10.1182/blood-2011-03-343467
Autor:
Nicola Gökbuget, Annette Sindram, Stefan Schwartz, Daniela Hubert, Eckhard Thiel, Dieter Hoelzer, Thomas Burmeister, Lars Fischer
Publikováno v:
Haematologica. 95:241-246
Background The t(9;22) and t(4;11) chromosomal translocations, which generate the BCR-ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia in adults. However, the prognostic impact of other rarer fusion genes is les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a9320235a4d01675f6d4ac3f1497f5
https://doi.org/10.3324/haematol.2009.011346
https://doi.org/10.3324/haematol.2009.011346
Publikováno v:
Leukemia Research. 25:769-774
In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50cce02de282bbf27940b6ba7174eac5
https://doi.org/10.1016/s0145-2126(01)00025-x
https://doi.org/10.1016/s0145-2126(01)00025-x
Autor:
Annette Sindram, Claudia D. Baldus, Olga Blau, Igor Wolfgang Blau, Bernd Dörken, Antonio Pezzutto, Rimma Berenstein, Asiye Kar, Sophie Schlabitz, Ruhiye Cay, Claudia Seide
Publikováno v:
Blood. 122:2627-2627
Abnormal epigenetic regulation has been implicated in oncogenesis. Mutations in the DNA methyltransferase 3A (DNMT3A) gene were recently demonstrated in acute myeloid leukemia (AML) as a candidate for the initiating of lesions in AML with adverse cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4175783f762d513db257254046aabace
https://doi.org/10.1182/blood.v122.21.2627.2627
https://doi.org/10.1182/blood.v122.21.2627.2627
Publikováno v:
Blood. 118:4868-4868
Abstract 4868 FLT3-ITD occurs with a frequency of 35%–45% in normal karyotype AML and has an adverse impact on prognosis. FLT3-ITD mutations are very variable in length and position of the tandem duplication. We have analyzed 211 AML patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d8ceefca560263e25bf5e7d0b24cb7
https://doi.org/10.1182/blood.v118.21.4868.4868
https://doi.org/10.1182/blood.v118.21.4868.4868
Publikováno v:
Blood. 118:4482-4482
Abstract 4482 Allogeneic stem cell transplantation (alloSCT) is a curative treatment option for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Relapse after alloSCT is still a major cause for the treatment failure. Mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6722814237ab923c748a66a271e7cc0
https://doi.org/10.1182/blood.v118.21.4482.4482
https://doi.org/10.1182/blood.v118.21.4482.4482
Autor:
Eckhard Thiel, Thomas Burmeister, Sandra Heesch, Annette Sindram, Cornelia Schlee, Stefan Schwartz, Claudia D. Baldus, Isabelle Bartram
Publikováno v:
Blood. 116:1692-1692
Abstract 1692 Background: Acute leukemias of ambiguous lineage account for only 3–5% of all cases of acute leukemia and represent a heterogeneous group of rare, poorly characterized leukemia with adverse outcome. The aim of this study was to furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de9fdd7e2d5cf4b37071b328adac33d1
https://doi.org/10.1182/blood.v116.21.1692.1692
https://doi.org/10.1182/blood.v116.21.1692.1692
Autor:
Olga Blau, Elke Schuemann, Annette Sindram, Verena Nowak, Korinna Kuehne, Igor Wolfgang Blau, Eckhard Thiel, Wolf-Karsten Hofmann, Gundula Thiel, Claudia D. Baldus
Publikováno v:
Blood. 110:985-985
Introduction : The biology of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is heterogeneous. Ineffective hematopoiesis results from complex interactions between hematopoietic cells (HC) and the hematopoietic microenvironment. Bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b29e41202d9a24ed220a0d194a5db70
https://doi.org/10.1182/blood.v110.11.985.985
https://doi.org/10.1182/blood.v110.11.985.985