Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Annette Self"'
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Autor:
Paul A. Clarke, Federica Piccioni, Annette Self, Udai Banerji, Charlotte K. Milton, David E. Root, Steven R. Whittaker
Publikováno v:
Mol Cancer Ther
KRAS mutation is a key driver of pancreatic cancer and PI3K pathway activity is an additional requirement for Kras-induced tumorigenesis. Clinical trials of PI3K pathway inhibitors in pancreatic cancer have shown limited responses. Understanding the
Autor:
Steve Wagner, Georgios Vlachogiannis, Alexis De Haven Brandon, Melanie Valenti, Gary Box, Liam Jenkins, Caterina Mancusi, Annette Self, Floriana Manodoro, Ioannis Assiotis, Penny Robinson, Ritika Chauhan, Alistair G. Rust, Nik Matthews, Kate Eason, Khurum Khan, Naureen Starling, David Cunningham, Anguraj Sadanandam, Clare M. Isacke, Vladimir Kirkin, Nicola Valeri, Steven R. Whittaker
Publikováno v:
Oncogene. 38:5746-5746
A correction to this paper has been published and can be accessed via a link at the top of the paper.
Publikováno v:
Journal of Cell Science
Directional cell migration involves reorientation of the secretory machinery. However, the molecular mechanisms that control this reorientation are not well characterised. Here, we identify a new Rho effector protein, named FAM65A, which binds to act
Autor:
Nicola Valeri, Annette Self, Alexis De Haven Brandon, Ritika Chauhan, Vladimir Kirkin, Gary Box, Anguraj Sadanandam, Clare M. Isacke, Melanie Valenti, George Vlachogiannis, Steve Wagner, Liam Jenkins, Nik Matthews, Alistair G. Rust, Steven R. Whittaker, Caterina Mancusi, Katherine Eason
Publikováno v:
Cancer Research. 78:LB-094
Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi) trametinib failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify mechanisms of resistance to MEK inhibition we identified gene expression diff
Publikováno v:
Development. 144:e1.1-e1.1
Directional cell migration involves reorientation of the secretory machinery. However, the molecular mechanisms that control this reorientation are not well characterised. Here, we identify a new Rho effector protein, named FAM65A, which binds to act
Publikováno v:
Current biology : CB. 18(19)
Summary Background Tumor cells can move in a three-dimensional (3D) environment in either mesenchymal-type or amoeboid modes. In mesenchymal-type movement, cells have an elongated morphology with Rac-induced protrusions at the leading edge. Amoeboid