Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Annette Schmitt-Graeff"'
Autor:
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Cornelius Miething, Uta S. Martens, Khalid Shoumariyeh, Rosa P. Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R. Blazar, Burkhard Becher, Melanie Boerries, Robert Zeiser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD) have a low one-year survival rate. Identification and validation of novel targetable kinases in patients who experience corticosteroid-refractory-aGVHD may help
Externí odkaz:
https://doaj.org/article/cb63dbf7545c4a79898fb5a39c9842f1
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Eileen Haring, Geoffroy Andrieux, Franziska M. Uhl, Máté Krausz, Michele Proietti, Barbara Sauer, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Annette Schmitt-Graeff, Justus Duyster, Natalie Köhler, Bodo Grimbacher, Melanie Boerries, Konrad Aumann, Robert Zeiser, Petya Apostolova
Publikováno v:
Haematologica, Vol 107, Iss 7 (2021)
Acute graft-versus-host disease (GvHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), a potentially curative treatment for leukemia. Endoplasmic reticulum (ER) stress occurs when the protein folding ca
Externí odkaz:
https://doaj.org/article/3798a575b63446ca8e0e75508ae07a3d
Autor:
Eileen Haring, Franziska M. Uhl, Geoffroy Andrieux, Michele Proietti, Alla Bulashevska, Barbara Sauer, Lukas M. Braun, Enrique de Vega Gomez, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Marie Follo, Annette Schmitt-Graeff, Joerg Buescher, Justus Duyster, Bodo Grimbacher, Melanie Boerries, Erika L. Pearce, Robert Zeiser, Petya Apostolova
Publikováno v:
Haematologica, Vol 106, Iss 8 (2020)
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Externí odkaz:
https://doaj.org/article/63bfd079d0904bb389c7f5bf30a08018
Autor:
Wolfgang Kreisel, Adhara Lazaro, Jonel Trebicka, Markus Grosse Perdekamp, Annette Schmitt-Graeff, Peter Deibert
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10372 (2021)
The NO-cGMP signal transduction pathway plays a crucial role in tone regulation in hepatic sinusoids and peripheral blood vessels. In a cirrhotic liver, the key enzymes endothelial NO synthase (eNOS), soluble guanylate cyclase (sGC), and phosphodiest
Externí odkaz:
https://doaj.org/article/cdb8a0e81b894674af59f189148b2830
Autor:
Wolfgang Kreisel, Denise Schaffner, Adhara Lazaro, Jonel Trebicka, Irmgard Merfort, Annette Schmitt-Graeff, Peter Deibert
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6223 (2020)
Liver cirrhosis is a frequent condition with high impact on patients’ life expectancy and health care systems. Cirrhotic portal hypertension (PH) gradually develops with deteriorating liver function and can lead to life-threatening complications. O
Externí odkaz:
https://doaj.org/article/5ab8690752b8400a8b877095ce45afcd
Autor:
Christoph Walz, Georgia Metzgeroth, Claudia Haferlach, Annette Schmitt-Graeff, Alice Fabarius, Volker Hagen, Otto Prümmer, Stefan Rauh, Rüdiger Hehlmann, Andreas Hochhaus, Nicholas C.P. Cross, Andreas Reiter
Publikováno v:
Haematologica, Vol 92, Iss 2 (2007)
Background and Objectives We sought to identify new fusion genes with involvement of the platelet-derived growth factor receptor β gene (PDGFRB) in three patients presenting with various subtypes of chronic myeloproliferative disorders associated wi
Externí odkaz:
https://doaj.org/article/4ad34fbf7b10488eb932e8242a3cfaa2
Autor:
Annegrit, Decker, Franziska, Schauer, Adhara, Lazaro, Carmen, Monasterio, Arthur Robert, Schmidt, Annette, Schmitt-Graeff, Wolfgang, Kreisel
Publikováno v:
World Journal of Gastroenterology. 28:5893-5909
Lichen planus (LP) is a frequent, chronic inflammatory disease involving the skin, mucous membranes and/or skin appendages. Esophageal involvement in lichen planus (ELP) is a clinically important albeit underdiagnosed inflammatory condition. This nar
Autor:
Maryam Barsch, Henrike Salié, Alexandra Emilia Schlaak, Zhen Zhang, Moritz Hess, Lena Sophie Mayer, Catrin Tauber, Patricia Otto-Mora, Takuya Ohtani, Tobias Nilsson, Lara Wischer, Frances Winkler, Sasikant Manne, Andrew Rech, Annette Schmitt-Graeff, Peter Bronsert, Maike Hofmann, Christoph Neumann-Haefelin, Tobias Boettler, Stefan Fichtner-Feigl, Florian van Boemmel, Thomas Berg, Lorenza Rimassa, Luca Di Tommaso, Anwaar Saeed, Antonio D’Alessio, David J. Pinato, Dominik Bettinger, Harald Binder, E. John Wherry, Michael Schultheiss, Robert Thimme, Bertram Bengsch
Publikováno v:
Journal of Hepatology. 77:397-409
Despite recent translation of immunotherapies into clinical practice, the immunobiology of hepatocellular carcinoma (HCC), in particular the role and clinical relevance of exhausted and liver-resident T cells remain unclear. We therefore dissected th
Autor:
Robert Zeiser, Tilman Brummer, Melanie Boerries, Justus Duyster, Annette Schmitt-Graeff, Lukas M. Braun, Sandra Duquesne, Christine Dierks, Claudius Klein, Geoffroy Andrieux, Franziska Maria Uhl, Shaima'a Hamarsheh, Lena Osswald
The bone marrow microenvironment (BMME) is key player in regulation and maintenance of hematopoiesis. Oncogenic RAS mutations, causing constitutive activation of multiple tumor-promoting pathways, are frequently found in human cancer. So far in hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d9300956a84504938585998fec2dc2
https://doi.org/10.1158/1541-7786.c.6544992.v1
https://doi.org/10.1158/1541-7786.c.6544992.v1