Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Annette S. Little"'
Autor:
Tim M. Scales, Anett Rada-Kovacs, Helen N. Pemberton, Ceri M. Wiggins, Nicola J. McCarthy, Annette S. Little, David A. Sorrell
Publikováno v:
Cancer Research. 79:1927-1927
Cell panel screening of cancer lines grown in standard 2D conditions is a well-established component of the drug discovery toolbox. A sufficiently large cell line panel, reflecting the molecular heterogeneity within a cancer type/sub-type, is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaaf79ec0fa38e3d9b7cff9668927b82
https://doi.org/10.1158/1538-7445.am2019-1927
https://doi.org/10.1158/1538-7445.am2019-1927
Autor:
Nicola McCarthy, Annette S. Little, Tim M. Scales, Steffen Lawo, Syed Asad Rahman, Benedict C. S. Cross, Carlos le Sage, Jonathan D. Moore, Prince Panckier
Publikováno v:
Cancer Research. 78:409-409
Functional genomic screening with CRISPR-Cas9 has provided a powerful and precise new way to interrogate the phenotypic consequences of gene manipulation in high-throughput, unbiased analyses. Rapid development of pooled lentivirus and deep-sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b627887b1f5c28e2ed408fdea3df98
https://doi.org/10.1158/1538-7445.am2018-409
https://doi.org/10.1158/1538-7445.am2018-409
Autor:
Benedict C. S. Cross, Carlos le Sage, Steffen Lawo, Tim M. Scales, Syed Asad Rahman, Prince Panicker, Nicola J. McCarthy, Jonathan D. Moore, Annette S. Little
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Sci Rep
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Sci Rep
Pooled CRISPR–Cas9 knock out screens provide a valuable addition to the methods available for novel drug target identification and validation. However, where gene editing is targeted to amplified loci, the resulting multiple DNA cleavage events can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3961fcbced15ff95d491c667e20437
http://europepmc.org/articles/PMC5735189
http://europepmc.org/articles/PMC5735189
Autor:
Joanne L. Yarker, Steffen Lawo, Jonathan D. Moore, Caroline R. Archer, Benedict C. S. Cross, Alessandro Riccombeni, Jessica Hunt, Annette S. Little, Nicola J. McCarthy
Publikováno v:
Sci Rep
Scientific Reports
Scientific Reports
Components of the type II CRISPR–Cas complex in bacteria have been used successfully in eukaryotic cells to facilitate rapid and accurate cell line engineering, animal model generation and functional genomic screens. Such developments are providing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bb97cc5e0c2130bbdcb12540ffc7d9
https://hdl.handle.net/21.11116/0000-000B-7158-3
https://hdl.handle.net/21.11116/0000-000B-7158-3
Autor:
Annette S, Little, Kathryn, Balmanno, Matthew J, Sale, Scott, Newman, Jonathan R, Dry, Mark, Hampson, Paul A W, Edwards, Paul D, Smith, Simon J, Cook
Publikováno v:
Science signaling. 4(170)
The acquisition of resistance to protein kinase inhibitors is a growing problem in cancer treatment. We modeled acquired resistance to the MEK1/2 (mitogen-activated or extracellular signal–regulated protein kinase kinases 1 and 2) inhibitor selumet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03c3fa889f5edf4403fc6d5e744a0a63
https://pubmed.ncbi.nlm.nih.gov/21447798
https://pubmed.ncbi.nlm.nih.gov/21447798
Autor:
Rachel Leah, Ruth Feltell, Christopher Torrance, Ramu Mangena, Annette S. Little, D P Gitterman, Holly Astley, Kyla Grimshaw, David Hughes, Jessica Hunt
Publikováno v:
Molecular Cancer Therapeutics. 12:A148-A148
Successful drug development in oncology requires a deeper understanding of the functional consequences of the diverse genetic changes observed in human cancers. For example, responses to epidermal growth factor receptor (EGFR) inhibitors are observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cdab0794c09854ac6bfbada82dead25
https://doi.org/10.1158/1535-7163.targ-13-a148
https://doi.org/10.1158/1535-7163.targ-13-a148
Publikováno v:
Biochemical Society Transactions; Feb2012, Vol. 40 Issue 1, p73-78, 6p
Autor:
Sue Griffin, Holly Astley, Hélène A Benink, Suzanne Grooby, Rebecca R. Foster, Jeff Kelly, Jo Francis, Annette S. Little
Publikováno v:
Cancer Research. 73:5522-5522
To allow promoter activity and protein dynamics to be studied at endogenous levels for the first time, Horizon Discovery has developed suites of X-MAN™ reporter cell lines incorporating NanoLuc™ and HaloTag® technologies from Promega. By creatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8a4e5c3efe7203e4d38b287e3f99b5f
https://doi.org/10.1158/1538-7445.am2013-5522
https://doi.org/10.1158/1538-7445.am2013-5522
Autor:
Cross, Benedict C. S.1, Lawo, Steffen1, Archer, Caroline R.1, Hunt, Jessica R.1, Yarker, Joanne L.1, Riccombeni, Alessandro1, Little, Annette S.1, McCarthy, Nicola J.1, Moore, Jonathan D.1
Publikováno v:
Scientific Reports. 8/26/2016, p31782. 1p.
Autor:
Richard Tomlinson
On 12 April 1919, the Paris police arrested a bald, short, 50-year-old swindler at his apartment near the Gare du Nord, acting on a lead from a humble housemaid. A century later, Henri Désiré Landru remains the most notorious and enigmatic serial k