Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Annette Romeike"'
Autor:
Ronnie Chamanza, Stuart W. Naylor, Michela Gregori, Molly Boyle, Marcia E. Pereira Bacares, Elodie Drevon-Gaillot, Annette Romeike, Cynthia Courtney, Kelsey Johnson, Julie Turner, Nadine Swierzawski, Alok K. Sharma
Publikováno v:
Toxicologic Pathology. 50:607-627
To investigate the influence of geographical origin, age, and sex on toxicologically relevant spontaneous histopathology findings in cynomolgus macaques ( Macaca fascicularis), we performed a comparative analysis of historical control data (HCD) from
Autor:
Elizabeth Galbreath, Basel T. Assaf, Lisa M. Kattenhorn, Brad Bolon, Branka Grubor, Joy A. Cavagnaro, Laurence O. Whiteley, Julie A. Hutt, Annette Romeike
Publikováno v:
Toxicologic Pathology. 50:118-146
Sequencing of the human genome and numerous advances in molecular techniques have launched the era of genetic medicine. Increasingly precise technologies for genetic modification, manufacturing, and administration of pharmaceutical-grade biologics ha
Autor:
Lars Mecklenburg, Rebecca Ducore, Molly Boyle, Andrew Newell, Laura Boone, Joerg Luft, Annette Romeike, Ann-Kathrin Haverkamp, Keith Mansfield, JJ Baczenas, Nick Minor, Shelby L. O’Connor, David H. O’Connor
Hepatitis A virus (HAV) infects humans and non-human primates causing an acute self-limited illness. Three HAV genotypes have been described for humans and three genotypes have been described for non-human primates. We observed transiently elevated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feff11afc3b3550406a6882950b03644
https://doi.org/10.1101/2022.11.18.515766
https://doi.org/10.1101/2022.11.18.515766
Autor:
Brad Bolon, Sabine Francke, Jessica M. Caverly Rae, Evelyne Polack, Karen S. Regan, Elizabeth F. McInnes, Jamie K. Young, Kevin Keane, Rick Perry, Annette Romeike, Karyn Colman, Karl Jensen, Kyoko Nakano-Ito, Elizabeth J. Galbreath
Publikováno v:
Toxicologic pathology. 50(8)
This article describes the Society of Toxicologic Pathology’s (STP) five recommended (“best”) practices for appropriate use of informed (non-blinded) versus masked (blinded) microscopic evaluation in animal toxicity studies intended for regulat
Autor:
Kyathanahalli S. Janardhan, Radhakrishna Sura, Smita Salian-Mehta, Thierry Flandre, Xavier Palazzi, Doris Zane, Bhanu Singh, Binod Jacob, Renee Rosemary Hukkanen, Muthafar Al-Haddawi, Bindu Bennet, Victoria Laast, Donna Lee, Richard Peterson, Annette Romeike, Frederic Schorsch, Magali Guffroy
Publikováno v:
Toxicologic pathology. 50(8)
Nonclinical toxicology studies that are required to support human clinical trials of new drug candidates are generally conducted in a rodent and a non-rodent species. These studies typically contain a vehicle control group and low, intermediate, and
Autor:
Ronnie, Chamanza, Stuart W, Naylor, Michela, Gregori, Molly, Boyle, Marcia E, Pereira Bacares, Elodie, Drevon-Gaillot, Annette, Romeike, Cynthia, Courtney, Kelsey, Johnson, Julie, Turner, Nadine, Swierzawski, Alok K, Sharma
Publikováno v:
Toxicologic pathology. 50(5)
To investigate the influence of geographical origin, age, and sex on toxicologically relevant spontaneous histopathology findings in cynomolgus macaques (
Autor:
Radhakrishna Sura, Jonathan Werner, Molly H. Boyle, Christopher Houle, Begonya Garcia, Bindu Bennet, Annette Romeike, Karyn Colman, Anna-Lena Frisk, Susan A. Elmore
Publikováno v:
Toxicol Pathol
Toxicologic Pathology is the official journal of the Society of Toxicologic Pathology (STP), the British Society of Toxicological Pathology (BSTP), and the European Society of Toxicologic Pathology (ESTP). Toxicologic Pathology publishes articles rel
Autor:
Magdalena Wozniak, Jorge Luft, Peter Korytko, F. Runge, Serge Zander, Lars Mecklenburg, Anne von Keutz, Florian Timo Ludwig, Betina Pajaziti, Annette Romeike, Sven Korte
Publikováno v:
International Journal of Toxicology. 39:510-517
Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross the blood–brain barrier. Intrathecal injection is
Autor:
Elizabeth F. McInnes, Karl F. Jensen, Jamie K. Young, Jessica Caverly Rae, Elizabeth Galbreath, Evelyne Polack, Brad Bolon, Karen S. Regan, Kevin A. Keane, Rick Perry, Annette Romeike, Karyn Colman, Kyoko Nakano-Ito, Sabine Francke
Publikováno v:
Toxicologic pathology. 48(4)
The Society of Toxicologic Pathology (STP) explored current institutional practices for selecting between non-blinded versus blinded histopathologic evaluation during Good Laboratory Practice (GLP)-compliant, regulatory-type animal toxicity studies u
Autor:
Bevin Zimmerman, Brad Bolon, Robert H. Garman, Annamaria Braendli-Baiocco, David L. Hutto, Renaud Fleurance, Joan Lane, Sundeep Chandra, Annette Romeike, Aaron M. Sargeant, Bindu Bennet, Armando R. Irizarry Rovira
Publikováno v:
Toxicologic Pathology. 46:616-635
Colorless, intracytoplasmic vacuoles occur in multiple tissues in animals following repeated administration of polyethylene glycol (PEG)-conjugated molecules. The extent of vacuolation depends on physical characteristics and molecular backbone of the